| 1 | Mobile Infirmary Association | Health Care | $723.0M | $881.9M |
| 2 | Gulf Health Hospitals INC | Health Care | $429.7M | $411.9M |
| 3 | Infirmary Health System INC | Health Care | $107.1M | $523.9M |
| 4 | Community Foundation of South Alabama | Philanthropy, Voluntarism & Grantmaking | $92.7M | $111.4M |
| 5 | University of Mobile INC | Education | $48.1M | $73.7M |
| 6 | Franklin Primary Health Center INC | Health Care | $42.0M | $28.4M |
| 7 | Building Trades Afl-agc Welfare Fund | Unclassified | $34.2M | $34.9M |
| 8 | Goodwill Industries of the Gulf Coast INC | Employment | $33.6M | $55.9M |
| 9 | The University of South Alabama Professional Liability Trust Fund | Unclassified | $33.5M | $63.4M |
| 10 | South Alabama Regional Planning Commission | Community Improvement & Capacity Building | $31.7M | $17.1M |
| 11 | Spring Hill College | Education | $29.9M | $131.4M |
| 12 | Learning Tree INC | Unclassified | $29.6M | $19.5M |
| 13 | Alabama Forest Resources Center INC | Unclassified | $27.0M | $8.4M |
| 14 | J L Bedsole Foundation | Philanthropy, Voluntarism & Grantmaking | $25.4M | $55.0M |
| 15 | Ums-wright Corporation | Unclassified | $23.2M | $49.5M |
| 16 | Mercy Life of Alabama | Health Care | $19.7M | $23.4M |
| 17 | St. Pauls Episcopal School | Education | $19.6M | $28.5M |
| 18 | Gulf Regional Early Childhood Services INC | Human Services | $17.1M | $6.4M |
| 19 | University of South Alabama Foundation | Education | $16.1M | $458.3M |
| 20 | New Horizons Credit Union | Unclassified | $15.2M | $269.4M |
| 21 | Country Club of Mobile | Unclassified | $14.9M | $23.3M |
| 22 | Rjjb Family Foundation | Philanthropy, Voluntarism & Grantmaking | $14.4M | $32.3M |
| 23 | Faith Academy of Mobile INC | Education | $13.4M | $28.6M |
| 24 | Alabama High School of Mathematics and Science Foundation | Education | $12.9M | $14.0M |
| 25 | Maef Public Charter Schools Incorporated | Education | $12.8M | $4.5M |
| 26 | Infirmary Health Hospitals INC | Health Care | $12.5M | $11.2M |
| 27 | Infirmary Foundation INC | Health Care | $10.7M | $46.3M |
| 28 | Southwest Alabama Partnership for Training and Employment INC | Employment | $9.8M | $2.2M |
| 29 | Feeding Alabama | Food, Agriculture & Nutrition | $8.8M | $4.0M |
| 30 | Ben May Charitable Trust | Unclassified | $8.6M | $31.7M |
| 31 | Little Sisters of the Poor Home for the Aged INC | Health Care | $8.5M | $11.0M |
| 32 | Preservation Housing INC | Housing & Shelter | $8.0M | $39.4M |
| 33 | Hope for All Gulf Coast | Food, Agriculture & Nutrition | $7.2M | $6.4M |
| 34 | Covenant Academy of Mobile | Human Services | $6.8M | $10.7M |
| 35 | E a Roberts Charitable Tr 32-0013-01-4 | Philanthropy, Voluntarism & Grantmaking | $6.7M | $32.6M |
| 36 | Mobile Christian School | Unclassified | $6.6M | $8.5M |
| 37 | Mobile Area Chamber of Commerce | Unclassified | $6.3M | $2.4M |
| 38 | Crampton Trust | Unclassified | $6.0M | $17.8M |
| 39 | David J Cooper Chartiable Foundation INC | Philanthropy, Voluntarism & Grantmaking | $6.0M | $17.5M |
| 40 | Mobile Arts & Sports Association INC | Unclassified | $5.9M | $6.6M |
| 41 | Alabama Aviation Education Center Incorporated | Education | $5.7M | $9.3M |
| 42 | Hearin-chandler Foundation | Unclassified | $5.6M | $36.1M |
| 43 | International Brotherhood Electric Workers Neca Health & Welfare Fd | Unclassified | $5.5M | $8.2M |
| 44 | Mobile Convention & Visitors Corporation | Unclassified | $5.2M | $4.1M |
| 45 | Mssa Ila Supplemental Benefit Fund | Unclassified | $5.2M | $10.8M |
| 46 | Cb Foundation INC | Philanthropy, Voluntarism & Grantmaking | $5.1M | $42.2M |
| 47 | Core Project INC | Human Services | $5.1M | $475K |
| 48 | International Brotherhood of Elec Workers Health & Welfare Fund | Unclassified | $5.0M | $4.8M |
| 49 | Veterans Recovery Resources | Public & Societal Benefit | $5.0M | $17.6M |
| 50 | University of South Alabama General Liability Program | Unclassified | $4.6M | $8.8M |
| 51 | Asms Supporting Organization | Education | $4.6M | $10.7M |
| 52 | The Mobile Museum of Art INC | Arts, Culture & Humanities | $4.6M | $4.6M |
| 53 | Mobile Educators Credit Union | Unclassified | $4.4M | $109.1M |
| 54 | Mssa-ila Welfare Plan | Unclassified | $4.3M | $2.4M |
| 55 | Belle G Roberts Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $4.3M | $15.3M |
| 56 | Mobile Area Education Foundation | Unclassified | $4.2M | $1.7M |
| 57 | United Cerebral Palsy of Mobile INC | Unclassified | $4.1M | $3.4M |
| 58 | USA Research and Technology Corporation | Education | $4.1M | $34.6M |
| 59 | Louise B Hirs Charitable Unitrust | Religion-Related | $3.8M | $12.0M |
| 60 | Nikkis Haven Foundation | Philanthropy, Voluntarism & Grantmaking | $3.8M | $27.9M |
| 61 | United Way of Southwest Alabama INC | Philanthropy, Voluntarism & Grantmaking | $3.8M | $3.4M |
| 62 | John and Carolyn Conn Educational Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.7M | $1.6M |
| 63 | Southern District Federal Defender Program INC | Education | $3.7M | $36K |
| 64 | Ums-wright Foundation INC | Education | $3.5M | $12.1M |
| 65 | Ozanam Charitable Pharmacy INC | Health Care | $3.5M | $746K |
| 66 | Mobile Carnival Association INC | Recreation & Sports | $3.4M | $4.6M |
| 67 | Mitchell Foundation INC | Unclassified | $3.4M | $17.0M |
| 68 | First Light Community of Mobile INC | Unclassified | $3.4M | $3.8M |
| 69 | Mssa Ila Vacation Plan and Trust | Unclassified | $3.4M | $2.9M |
| 70 | Family Counseling Center of Mobile INC | Human Services | $3.4M | $1.9M |
| 71 | Dumas Wesley Community Center | Unclassified | $3.1M | $8.8M |
| 72 | Azalea City Credit Union | Unclassified | $3.1M | $43.1M |
| 73 | Magnolia Cemetery Perpetual Care Fund | Unclassified | $3.1M | $9.2M |
| 74 | Mechanical Contractors Assn Ua-119 Welfare Plan | Unclassified | $3.0M | $5.2M |
| 75 | Penelope House INC | Human Services | $3.0M | $5.3M |
| 76 | The Boys and Girls Clubs of South Alabama INC | Youth Development | $3.0M | $6.1M |
| 77 | Damon Thompson Ministries | Religion-Related | $3.0M | $5.6M |
| 78 | 1711 Dundee Way Foundation | Philanthropy, Voluntarism & Grantmaking | $2.9M | $3.5M |
| 79 | Ahepa 310-VII INC | Housing & Shelter | $2.9M | $2.8M |
| 80 | Mobile Area Chamber of Commerce Foundation INC | Community Improvement & Capacity Building | $2.8M | $3.5M |
| 81 | Mobile Memorial Gardens INC | Unclassified | $2.8M | $12.1M |
| 82 | Girl Scouts of Southern Alabama INC | Unclassified | $2.7M | $7.9M |
| 83 | Ahepa 310-VI INC | Housing & Shelter | $2.6M | $2.6M |
| 84 | Nan H Altmayer Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $2.5M | $11.5M |
| 85 | Habitat for Humanity International INC | Housing & Shelter | $2.5M | $10.2M |
| 86 | Ahepa 310-V INC | Housing & Shelter | $2.4M | $2.3M |
| 87 | Divine Mercy Province of Heralds of Good News | Human Services | $2.4M | $655K |
| 88 | People for Care & Learning | Public Safety, Disaster Preparedness & Relief | $2.3M | $779K |
| 89 | Trust Created U/w of George Marinos | Unclassified | $2.3M | $6.2M |
| 90 | Downtown Mobile District Management Corporation | Community Improvement & Capacity Building | $2.3M | $1.2M |
| 91 | Mobile Symphony INC | Arts, Culture & Humanities | $2.2M | $1.5M |
| 92 | South Alabama Medical Science Foundation | Medical Research | $2.1M | $13.2M |
| 93 | Jaguar Athletic Fund INC | Recreation & Sports | $2.1M | $1.4M |
| 94 | Greater Gulf State Fair | Unclassified | $2.1M | $3.0M |
| 95 | Alton N Scott Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $2.1M | $8.8M |
| 96 | Explore Center INC | Arts, Culture & Humanities | $2.0M | $4.4M |
| 97 | Government Street Presbyterian Church Endowment Tr | Philanthropy, Voluntarism & Grantmaking | $2.0M | $4.2M |
| 98 | Southwest Chapter of the Alabama Coalition of Citizens with | Unclassified | $2.0M | $1.4M |
| 99 | Athlestan Club | Unclassified | $1.9M | $1.1M |
| 100 | Victory Health Partners INC | Health Care | $1.9M | $1.0M |