| 1 | Mercy Health Services Iowa Corp. | Health Care | $976.0M | $874.1M |
| 2 | Northwest Iowa Hospital Corporation | Health Care | $275.8M | $238.6M |
| 3 | Siouxland Regional Cancer Center | Diseases, Disorders & Medical Disciplines | $73.2M | $22.6M |
| 4 | Goodwill of the Great Plains | Employment | $54.6M | $60.3M |
| 5 | Siouxland Community Health Center | Health Care | $48.2M | $54.3M |
| 6 | Briar Cliff University | Education | $44.3M | $50.6M |
| 7 | Boys and Girls Home Residential Treatment Centers INC | Mental Health & Crisis Intervention | $33.2M | $20.6M |
| 8 | Mid-step Services INC | Human Services | $30.7M | $24.1M |
| 9 | Siouxland Pace INC | Health Care | $28.1M | $17.4M |
| 10 | Sunrise Manor | Health Care | $14.5M | $21.6M |
| 11 | Community Action Agency of Siouxland | Unclassified | $12.8M | $6.1M |
| 12 | Siouxland Community Foundation | Philanthropy, Voluntarism & Grantmaking | $12.7M | $50.8M |
| 13 | Siouxland Mental Health Services | Mental Health & Crisis Intervention | $11.3M | $8.8M |
| 14 | Holy Spirit Retirement Home INC | Unclassified | $10.0M | $8.8M |
| 15 | Wilson Trailer Company Employee Health Care Fund | Unclassified | $8.9M | $4.9M |
| 16 | Catholic Charities of the Diocese of Sioux City | Unclassified | $8.4M | $12.1M |
| 17 | Food Bank of Siouxland INC | Unclassified | $8.3M | $3.3M |
| 18 | Opportunities Unlimited | Unclassified | $8.1M | $5.2M |
| 19 | Siouxland Human Investment Partnership INC | Human Services | $7.8M | $7.4M |
| 20 | Crittenton Center | Human Services | $7.7M | $4.1M |
| 21 | Mid-america Agri-industries Voluntary Employees Beneficiary | Unclassified | $7.6M | $257K |
| 22 | Art Center Association of Sioux City | Unclassified | $7.1M | $10.7M |
| 23 | Baum-harmon Mercy Hospital | Health Care | $6.8M | $2.8M |
| 24 | Hospice of Siouxland | Health Care | $6.3M | $9.5M |
| 25 | Gilchrist Foundation | Philanthropy, Voluntarism & Grantmaking | $6.0M | $33.4M |
| 26 | United Food and Commercial Workers International Union | Unclassified | $5.9M | $3.1M |
| 27 | Siouxland Community Christian School INC | Education | $5.2M | $14.0M |
| 28 | Missouri River Historical Develop- Ment INC | Unclassified | $4.2M | $6.3M |
| 29 | United Way of Siouxland | Philanthropy, Voluntarism & Grantmaking | $3.8M | $6.7M |
| 30 | Chesterman Family Foundation | Philanthropy, Voluntarism & Grantmaking | $3.7M | $7.6M |
| 31 | The Gospel Mission | Human Services | $3.6M | $5.1M |
| 32 | Sioux City Country Club Corp. | Unclassified | $3.6M | $2.9M |
| 33 | Wilson Trailer Sales Health Care Plan | Mutual & Membership Benefit | $3.6M | $1.6M |
| 34 | Boys and Girls Home of Sioux City Iowa | Unclassified | $3.1M | $2.1M |
| 35 | St. Lukes Health System INC | Unclassified | $2.9M | $23.7M |
| 36 | Saturday in the Park INC | Arts, Culture & Humanities | $2.8M | $674K |
| 37 | Orpheum Theatre Preservation Project Ltd | Arts, Culture & Humanities | $2.7M | $8.4M |
| 38 | St. Lukes Health Foundation of Sioux City Iowa | Unclassified | $2.7M | $7.5M |
| 39 | Sioux City Symphony Orchestra Association | Arts, Culture & Humanities | $2.7M | $4.9M |
| 40 | Camp High Hopes | Human Services | $2.6M | $11.1M |
| 41 | Bomgaars Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.6M | $5.6M |
| 42 | Iowa Statewide Poison Control Center | Public Safety, Disaster Preparedness & Relief | $2.5M | $3.1M |
| 43 | Western Iowa Tech Community College Foundation | Unclassified | $2.5M | $10.6M |
| 44 | Monsignor Lafferty Tuition Foundation | Unclassified | $2.4M | $2.4M |
| 45 | St. Lukes Health Resources | Health Care | $2.2M | $1.3M |
| 46 | Habitat for Humanity International INC | Unclassified | $2.0M | $4.0M |
| 47 | Green Valley Floyd Golf Corp. | Unclassified | $1.9M | $1.9M |
| 48 | Siouxland Humane Society INC | Animal-Related | $1.8M | $5.7M |
| 49 | Siouxland Initiative | Unclassified | $1.7M | $1.4M |
| 50 | Siouxland Sports Academy | Recreation & Sports | $1.6M | $18K |
| 51 | St. James Fund | Unclassified | $1.5M | $64.1M |
| 52 | Boys and Girls Club of Siouxland INC | Youth Development | $1.5M | $5.7M |
| 53 | Irving & Elizabeth Jensen Foundation | Unclassified | $1.4M | $317K |
| 54 | Sioux City Chamber of Commerce | Unclassified | $1.4M | $2.8M |
| 55 | Safeplace | Unclassified | $1.4M | $2.0M |
| 56 | Queen of Peace INC | Unclassified | $1.3M | $5.8M |
| 57 | Sioux City Parks & Recreation Foundation INC | Recreation & Sports | $1.3M | $2.0M |
| 58 | Youth for Christ USA INC | Youth Development | $1.3M | $826K |
| 59 | Girls Incorporated of Sioux City | Youth Development | $1.3M | $8.1M |
| 60 | New Perspectives INC | Employment | $1.2M | $1.5M |
| 61 | Warming Shelter INC | Housing & Shelter | $1.2M | $1.0M |
| 62 | Mercy Medical Center-sioux City Foundation | Health Care | $1.2M | $4.4M |
| 63 | Gleeson Foundation | Unclassified | $1.1M | $3.4M |
| 64 | Mary J Treglia Community House | Human Services | $1.1M | $1.1M |
| 65 | Siouxland Medical Education Foundation INC | Health Care | $1.1M | $2.0M |
| 66 | Siouxland Expo Center | Arts, Culture & Humanities | $1.1M | $17.9M |
| 67 | International Brotherhood of Electrical Workers | Unclassified | $1.1M | $1.9M |
| 68 | Perley Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.1M | $888K |
| 69 | Pheasant Acres Apartments INC | Unclassified | $1.0M | $1.5M |
| 70 | Simple Life INC | Human Services | $1.0M | $458K |
| 71 | Center for Siouxland | Human Services | $1.0M | $2.4M |
| 72 | Ronald McDonald House Charities of Siouxland INC | Health Care | $998K | $3.3M |
| 73 | Friends of Fm 90 | Arts, Culture & Humanities | $997K | $2.9M |
| 74 | Siouxland Economic Development Corporation | Unclassified | $992K | $5.2M |
| 75 | Sanford Center | Unclassified | $978K | $1.2M |
| 76 | Sioux City Regional Convention and Visitors Bureau | Community Improvement & Capacity Building | $958K | $338K |
| 77 | Equipping the Persecuted | International, Foreign Affairs & National Security | $955K | $3K |
| 78 | Sioux City Lewis & Clark Interpretive Center | Arts, Culture & Humanities | $910K | $4.9M |
| 79 | Catholic School Foundation of the Diocese of Sioux City Iowa | Education | $907K | $20.3M |
| 80 | Abu Bekr Shriners | Community Improvement & Capacity Building | $906K | $1.5M |
| 81 | Siouxland Tanzania Educational Medical Ministries | Human Services | $859K | $202K |
| 82 | Orpheum Theatre Endowment INC | Arts, Culture & Humanities | $853K | $7.2M |
| 83 | Ancient & Accepted Scottish Rite of Free Masonry So Juris of USA | Unclassified | $845K | $2.7M |
| 84 | Titus Fellowship of Sioux City Ltd | Health Care | $837K | $4.9M |
| 85 | Michael L and Margie a Bennett Foundation | Philanthropy, Voluntarism & Grantmaking | $828K | $413K |
| 86 | Childrens Museum of Siouxland INC | Arts, Culture & Humanities | $794K | $4.9M |
| 87 | Her Health Womens Center | Unclassified | $760K | $817K |
| 88 | Agape Community Services INC | Religion-Related | $708K | $177K |
| 89 | Northwest Iowa Regional Board of Realtors | Unclassified | $692K | $1.3M |
| 90 | Independence Village INC | Unclassified | $680K | $1.1M |
| 91 | Sky Ranch Behavioral Services | Mental Health & Crisis Intervention | $597K | $219K |
| 92 | Samuel and Gussie Bernstein Foundation Rvoc Tr | Unclassified | $597K | $2.6M |
| 93 | Family Services INC | Human Services | $582K | $385K |
| 94 | Siouxland Sharks Swimming Club | Unclassified | $556K | $17K |
| 95 | Down Town Partners Sioux City | Unclassified | $553K | $523K |
| 96 | Siouxland Youth Hockey Association INC | Recreation & Sports | $550K | $1.2M |
| 97 | Western Iowa Community Improvement Regional Housing Trust Fund | Housing & Shelter | $549K | $320K |
| 98 | Pokey & Colin Jensen Foundation | Unclassified | $547K | $1.0M |
| 99 | Tigger & Irving Jensen Foundation | Unclassified | $541K | $705K |
| 100 | Big Brothers Big Sisters of Siouxland | Unclassified | $535K | $201K |