| 1 | Sioux Valley Memorial Hospital Association | Health Care | $60.8M | $109.9M |
| 2 | Cherokee County Rural Water District No One | Unclassified | $2.6M | $14.7M |
| 3 | Brummer Stiles Duncan Scholarship Fund | Unclassified | $2.6M | $8.6M |
| 4 | United Christians International | Religion-Related | $1.6M | $1.7M |
| 5 | Pritchard Educational Fund | Unclassified | $1.6M | $9.5M |
| 6 | William L & Ethel Gund Memorial Fund | Unclassified | $971K | $1.4M |
| 7 | Montiford and Mary Beck Doupe Scholarship Fund | Education | $836K | $1.7M |
| 8 | Ecumenical Institute for Clinical Pastoral Education | Religion-Related | $649K | $1.0M |
| 9 | Brunk Educational Fund | Philanthropy, Voluntarism & Grantmaking | $571K | $4.8M |
| 10 | Tiel Sanford Memorial Fund | Arts, Culture & Humanities | $496K | $3.5M |
| 11 | Cherokee Day Care INC | Human Services | $477K | $544K |
| 12 | Robert Hartwig Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $401K | $2.6M |
| 13 | Cherokee Regional Medical Center Foundation | Health Care | $324K | $1.8M |
| 14 | Cherokee Educational Foundation | Education | $308K | $979K |
| 15 | Cherokee Area Economic Development Corporation | Unclassified | $298K | $865K |
| 16 | Cherokee County Fair Association | Unclassified | $238K | $1.3M |
| 17 | Cherokee Community Foundation | Philanthropy, Voluntarism & Grantmaking | $209K | $68K |
| 18 | Raymond a and Florence D Erlandson Foundation | Philanthropy, Voluntarism & Grantmaking | $174K | $3.2M |
| 19 | Cherokee Chamber of Commerce | Unclassified | $171K | $174K |
| 20 | E Joe Lundsgaard Educational Trust | Philanthropy, Voluntarism & Grantmaking | $157K | $503K |
| 21 | Brummer Legacy Foundation INC | Arts, Culture & Humanities | $139K | $88K |
| 22 | Specht Educational Tr | Education | $129K | $1.2M |
| 23 | Iowa Farm Bureau Federation | Unclassified | $96K | $1.2M |
| 24 | Florence Frisbie Scholarship Fund | Education | $95K | $200K |
| 25 | Cherokee County Residential Services INC | Human Services | $72K | $716K |
| 26 | Cherokee Community Theatre | Unclassified | $44K | $264K |
| 27 | Carstens Educational Fund | Education | $34K | $895K |
| 28 | Joseph P Redden Trust | Unclassified | $31K | $1.4M |
| 29 | William H Guest & Edith M Guest Educational Trust | Education | $15K | $519K |
| 30 | Friends of Aurelia | Arts, Culture & Humanities | $15K | $16K |
| 31 | Carroll C Mongan Trust | Education | $13K | $410K |
| 32 | Sanford Museum Association | Unclassified | $10K | $87K |
| 33 | Pearl Kenny Trust | Unclassified | $4K | $24K |
| 34 | Nonken Tr | Education | $2K | $48K |
| 35 | Fannye Ament Educational Tr | Philanthropy, Voluntarism & Grantmaking | $643 | $10K |
| 36 | Crossroads Christian Church | Religion-Related | $0 | $0 |
| 37 | Cherokee Volunteer Fire Department Foundation | Public Safety, Disaster Preparedness & Relief | $0 | $0 |
| 38 | Catholic Daughters of the Americas | Unclassified | $0 | $0 |
| 39 | Catholic Daughters of the Americas | Unclassified | $0 | $0 |
| 40 | Royal and Select Masters of Iowa | Unclassified | $0 | $0 |
| 41 | Burning Bush Chapter 90 Royal Arch Masons | Mutual & Membership Benefit | $0 | $0 |
| 42 | Friends of Cherokee Braves Speech | Arts, Culture & Humanities | $0 | $0 |
| 43 | Robert Porter Educational Trust | Education | $0 | $0 |
| 44 | Breath of Life Assembley of God | Unclassified | $0 | $0 |
| 45 | Healing Heart Solutions | Human Services | $0 | $0 |
| 46 | Cherokee Public Library Foundation | Education | $0 | $0 |
| 47 | Ancient Free & Accepted Masons of Iowa | Mutual & Membership Benefit | $0 | $0 |
| 48 | Immaculate Conception Church | Unclassified | $0 | $0 |
| 49 | Trinity Lutheran Church | Unclassified | $0 | $0 |
| 50 | First Baptist Church | Unclassified | $0 | $0 |
| 51 | We Share Because We Care-cherokee County Fund | Housing & Shelter | $0 | $0 |
| 52 | Depot Renovation INC | Arts, Culture & Humanities | $0 | $0 |
| 53 | Friends of Conservation INC | Environment | $0 | $0 |
| 54 | Living Word Ministries INC | Unclassified | $0 | $0 |
| 55 | PTA Iowa Congress | Unclassified | $0 | $0 |
| 56 | Friends of the Cherokee Public Library | Education | $0 | $0 |
| 57 | Cherokee Columbus Club | Unclassified | $0 | $0 |
| 58 | Cherokee Rotary Club | Unclassified | $0 | $0 |
| 59 | Association of Wa Tan Ye Clubs | Unclassified | $0 | $0 |
| 60 | American Legion Post 0230 Treptow | Unclassified | $0 | $0 |
| 61 | National Society of the Daughters of the American Revolution | Arts, Culture & Humanities | $0 | $0 |
| 62 | Cherokee Symphony | Unclassified | $0 | $0 |
| 63 | Veterans of Foreign Wars of the United States Dept of Iowa | Unclassified | $0 | $0 |
| 64 | Knights of Columbus | Unclassified | $0 | $0 |
| 65 | Take Your Key | Education | $0 | $0 |
| 66 | Max Wildlife Foundation | Animal-Related | $0 | $0 |
| 67 | Friends of Cherokee Braves Golf | Recreation & Sports | $0 | $0 |
| 68 | Richard Hein Trust | Unclassified | $0 | $0 |