| 1 | Commonspirit Health | Health Care | $3.4B | $9.9B |
| 2 | Craig Hospital | Health Care | $205.0M | $380.2M |
| 3 | Christian Living Neighborhoods | Religion-Related | $76.8M | $229.5M |
| 4 | Allhealth Network | Mental Health & Crisis Intervention | $72.8M | $31.1M |
| 5 | Mgma-acmpe | Community Improvement & Capacity Building | $53.6M | $78.5M |
| 6 | Toastmasters International | Recreation & Sports | $43.3M | $55.4M |
| 7 | Kent Denver Country Day School | Education | $39.4M | $148.3M |
| 8 | Contractors Health Trust | Unclassified | $35.7M | $7.4M |
| 9 | Instructional Telecommunications Foundation INC | Public & Societal Benefit | $31.7M | $38.0M |
| 10 | Medical Education Resources INC | Unclassified | $27.8M | $3.0M |
| 11 | David Merage Foundation for Confronting Antisemitism | Philanthropy, Voluntarism & Grantmaking | $25.4M | $25.4M |
| 12 | Society for Mining Metallurgy and Exploration INC | Science & Technology | $23.7M | $41.3M |
| 13 | Golden Pond Foundation | Philanthropy, Voluntarism & Grantmaking | $22.1M | $27.9M |
| 14 | Christian Living Communities | Housing & Shelter | $20.1M | $38.0M |
| 15 | Craig Hospital Foundation | Health Care | $18.7M | $38.6M |
| 16 | Hope Online Learning Academy Co-op | Education | $17.4M | $4.5M |
| 17 | Coloradans for Responsible Energy Development | Unclassified | $12.4M | $2.5M |
| 18 | Cottonwood Community Alternatives INC | Human Services | $11.1M | $9.0M |
| 19 | Sabrina Merage Foundation | Philanthropy, Voluntarism & Grantmaking | $10.6M | $15.5M |
| 20 | Bella Natural Womens Care | Unclassified | $10.1M | $2.0M |
| 21 | American College of Veterinary Internal Medicine | Unclassified | $9.9M | $15.8M |
| 22 | Cadence International | Unclassified | $9.9M | $12.9M |
| 23 | Parker Performing Arts School | Education | $9.6M | $21.4M |
| 24 | Early Learning Ventures | Philanthropy, Voluntarism & Grantmaking | $9.6M | $5.9M |
| 25 | Joshua INC | Education | $9.5M | $3.8M |
| 26 | Integrated Family Community Services | Human Services | $7.5M | $1.9M |
| 27 | Kaizen Food Rescue | Food, Agriculture & Nutrition | $7.3M | $326K |
| 28 | Catholic Health Initiatives Virtual Health Services | Health Care | $6.8M | $29.4M |
| 29 | Denver Broncos Foundation | Philanthropy, Voluntarism & Grantmaking | $6.7M | $1.2M |
| 30 | Opera Colorado | Arts, Culture & Humanities | $6.1M | $2.8M |
| 31 | Colorado Association of Realtors | Unclassified | $6.1M | $10.1M |
| 32 | Commonspirit Health Foundation | Religion-Related | $5.8M | $14.6M |
| 33 | Advance Colorado | Public & Societal Benefit | $5.7M | $1.7M |
| 34 | David and Laura Merage Foundation | Philanthropy, Voluntarism & Grantmaking | $5.2M | $69.6M |
| 35 | Sme Foundation | Environment | $4.9M | $6.9M |
| 36 | Museum of Outdoor Arts | Unclassified | $4.8M | $19.6M |
| 37 | Youth for Christ Foundation | Unclassified | $4.6M | $33.0M |
| 38 | Colorado Soccer Association | Recreation & Sports | $4.5M | $4.9M |
| 39 | Mary M Dower Benevolent Corporation | Unclassified | $4.1M | $16.7M |
| 40 | Isaiah 58 12 Foundation INC | Religion-Related | $4.1M | $26.2M |
| 41 | Denver Police Retireee Health Fund | Unclassified | $3.9M | $9.9M |
| 42 | Truckers Against Trafficking | Education | $3.6M | $6.5M |
| 43 | Project Helping | Mental Health & Crisis Intervention | $3.6M | $786K |
| 44 | W J D Foundation | Unclassified | $3.6M | $6.5M |
| 45 | Freedom Service Dogs INC | Human Services | $3.6M | $11.3M |
| 46 | Desta | Employment | $3.3M | $1.8M |
| 47 | Avodah Farms | Human Services | $3.0M | $1.5M |
| 48 | Andre and Katherine Merage Foundation Colorado | Philanthropy, Voluntarism & Grantmaking | $2.9M | $36.0M |
| 49 | Colorado Christian Academy | Education | $2.8M | $1.8M |
| 50 | Revelations in Christ Ministries | Religion-Related | $2.8M | $457K |
| 51 | Maffei Foundation | Philanthropy, Voluntarism & Grantmaking | $2.7M | $7.7M |
| 52 | Alternatives Pregnancy Center INC | Health Care | $2.6M | $4.4M |
| 53 | Commonspirit Health Research Institute | Health Care | $2.4M | $52.1M |
| 54 | Challenge Foundation INC | Education | $2.3M | $5.4M |
| 55 | Sylvania Franciscan Health | Health Care | $2.3M | $62.2M |
| 56 | Skyline Soccer Association | Unclassified | $2.2M | $3.4M |
| 57 | Aurora Fire Fighters Retiree Health Fund | Mutual & Membership Benefit | $2.1M | $12.2M |
| 58 | Colorado Skies Academy | Education | $2.1M | $10.5M |
| 59 | Autrey Foundation | Philanthropy, Voluntarism & Grantmaking | $2.0M | $2.8M |
| 60 | Saint John Institute | Education | $2.0M | $3.3M |
| 61 | The English Advantage Mexico | Unclassified | $2.0M | $2.7M |
| 62 | Colorado Institute of Developmental Pediatrics INC | Unclassified | $1.9M | $2.2M |
| 63 | Joshua INC | Education | $1.9M | $859K |
| 64 | One Good Turn | Human Services | $1.8M | $348K |
| 65 | Rocky Mountain Minority Supplier Development Council | Community Improvement & Capacity Building | $1.8M | $2.1M |
| 66 | Aurora Police Retiree Health Fund | Mutual & Membership Benefit | $1.8M | $3.6M |
| 67 | Michael S Jacobs Foundation INC | Education | $1.7M | $52K |
| 68 | Alltricity Network | Unclassified | $1.6M | $1.6M |
| 69 | International Broadcaster Coalition Against Piracy INC | Community Improvement & Capacity Building | $1.6M | $3.5M |
| 70 | Mike Leprino Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.5M | $3.7M |
| 71 | Westcliffe Housing Foundation INC | Housing & Shelter | $1.5M | $2.1M |
| 72 | Cancer League of Colorado INC | Medical Research | $1.3M | $993K |
| 73 | Treeline Pass | Human Services | $1.3M | $943K |
| 74 | Kowalski Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.2M | $2.3M |
| 75 | Walter a and Charlotte Soule Family Foundation | Unclassified | $1.1M | $248K |
| 76 | Denver Lyric Opera Guild | Arts, Culture & Humanities | $1.1M | $2.0M |
| 77 | Harwell Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.1M | $1.0M |
| 78 | Brave | Religion-Related | $1.1M | $2.1M |
| 79 | Arapahoe Tennis Club | Unclassified | $1.0M | $4.7M |
| 80 | Colorado Mining Association | Unclassified | $1.0M | $1.4M |
| 81 | Breakthrough Alliance of Colorado INC | Crime & Legal-Related | $1.0M | $372K |
| 82 | Mut Family Foundation | Philanthropy, Voluntarism & Grantmaking | $975K | $4.4M |
| 83 | Front Range Volleyball Club INC | Unclassified | $965K | $149K |
| 84 | Havercroft Family Foundation | Philanthropy, Voluntarism & Grantmaking | $964K | $1.3M |
| 85 | Colorado Opportunity Foundation | Civil Rights, Social Action & Advocacy | $950K | $2K |
| 86 | Associated Builders & Contractors INC | Unclassified | $936K | $828K |
| 87 | Colorado Volleyball Association | Recreation & Sports | $925K | $305K |
| 88 | The Hackstock Family Foundaton | Philanthropy, Voluntarism & Grantmaking | $921K | $932K |
| 89 | Red Robin Foundation | Education | $905K | $310K |
| 90 | Vote for America | Public & Societal Benefit | $900K | $73K |
| 91 | Colorado Prospects Ltd | Recreation & Sports | $871K | $29K |
| 92 | Colorado Association of Realtors Foundation | Housing & Shelter | $834K | $2.6M |
| 93 | Piney Creek Recreation Association | Unclassified | $820K | $1.0M |
| 94 | Mgma Realty Corp. | Unclassified | $807K | $979K |
| 95 | Home Health Care Professionals INC | Unclassified | $781K | $1.1M |
| 96 | Opera Colorado Foundation | Philanthropy, Voluntarism & Grantmaking | $781K | $7.3M |
| 97 | Joliet Foundation | Unclassified | $769K | $1.5M |
| 98 | Colorado Asian Culture and Education Network | Arts, Culture & Humanities | $762K | $2.3M |
| 99 | Downing Street Foundation | Philanthropy, Voluntarism & Grantmaking | $746K | $7.9M |
| 100 | Veterans of Foreign Wars of the United States Dept of Colorado | Unclassified | $745K | $393K |