| 1 | Kaiser Foundation Health Plan of Colorado Aurora | E | $5.2B | $4.5B | $2.6B |
| 2 | Commonspirit Health Englewood | E | $3.4B | $3.4B | $9.9B |
| 3 | Catholic Health Initiatives Colorado Centennial | E | $3.3B | $3.3B | $6.1B |
| 4 | Poudre Valley Health Care INC Fort Collins | E | $3.1B | $970.2M | $12.0B |
| 5 | Childrens Hospital Colorado Aurora | E | $2.0B | $2.0B | $2.4B |
| 6 | Portercare Adventist Health System Greenwood Village | E | $1.8B | $1.8B | $1.8B |
| 7 | University of Denver Denver | B | $1.4B | $834.9M | $2.2B |
| 8 | Avenir Foundation INC Lakewood | Z | $1.2B | $0 | $1.2B |
| 9 | Parkview Medical Center INC Pueblo | E | $1.2B | $518.8M | $617.8M |
| 10 | Ryan Foundation Greenwood Vlg | Z | $1.2B | $0 | $1.5B |
| 11 | Poudre Valley Medical Group LLC Fort Collins | E | $1.0B | $1.0B | $194.9M |
| 12 | Alliance for Sustainable Energy LLC Lakewood | U | $1.0B | $1.0B | $232.2M |
| 13 | Medical Center of the Rockies Fort Collins | E | $996.4M | $642.0M | $750.7M |
| 14 | The Colorado Health Foundation Denver | E | $968.3M | $0 | $2.9B |
| 15 | Anschutz Foundation Denver | T | $868.0M | $0 | $1.9B |
| 16 | Colorado Access Aurora | Z | $790.2M | $790.2M | $213.1M |
| 17 | Delta Dental of Colorado Greenwood Vlg | E | $681.0M | $680.9M | $106.6M |
| 18 | Credit Unions Chartered in the State of Colorado Colorado Springs | Z | $654.5M | $594.7M | $9.8B |
| 19 | Saint Joseph Hospital Denver | E | $649.1M | $645.4M | $1.0B |
| 20 | Young Life Colorado Spgs | O | $588.9M | $556.3M | $440.0M |
| 21 | Denver Health Medical Plan INC Denver | Z | $572.8M | $536.0M | $89.0M |
| 22 | Valley View Hospital Association Glenwood Spgs | E | $513.9M | $368.5M | $678.9M |
| 23 | Hexagon Foundation Colorado Spgs | X | $506.0M | $506.0M | $522.9M |
| 24 | Credit Unions Chartered in the State of Colorado Greenwood Vlg | Z | $502.6M | $496.7M | $8.6B |
| 25 | United States Olympic & Paralympic Committee Colorado Springs | N | $496.3M | $496.3M | $602.2M |
| 26 | Credit Unions Chartered in the State of Colorado Lone Tree | Z | $490.6M | $360.6M | $4.6B |
| 27 | Charter Fund INC Denver | T | $486.3M | $232.4M | $720.3M |
| 28 | Denver Foundation Denver | T | $464.2M | $208.3M | $1.3B |
| 29 | University of Colorado Foundation Denver | B | $456.1M | $456.1M | $3.5B |
| 30 | Rose Community Foundation Denver | T | $442.4M | $48.0M | $399.6M |
| 31 | Christian Community Foundation INC Colorado Spgs | T | $432.5M | $337.6M | $746.4M |
| 32 | National Jewish Health Denver | E | $428.6M | $401.1M | $414.0M |
| 33 | Commonspirit Mountain Region Centennial | E | $419.0M | $418.4M | $431.9M |
| 34 | United Power INC Brighton | Z | $416.1M | $416.1M | $1.4B |
| 35 | Core Electric Cooperative Sedalia | Z | $414.4M | $413.2M | $1.4B |
| 36 | Vail Clinic INC Vail | E | $400.9M | $389.3M | $853.2M |
| 37 | University Corporation for Atmospheric Research Boulder | U | $400.2M | $311.0M | $356.7M |
| 38 | Ahimsa Foundation Niwot | D | $399.3M | $0 | $1.0B |
| 39 | Colorado College Th Colorado Spgs | B | $379.1M | $294.1M | $1.5B |
| 40 | Colorado School of Mines Foundation Golden | B | $326.6M | $53.6M | $537.8M |
| 41 | Goodwill of Colorado Colorado Spgs | J | $313.9M | $183.4M | $283.5M |
| 42 | Colorado West Healthcare System Grand Jct | E | $312.8M | $312.5M | $260.5M |
| 43 | Zoma Foundation Denver | T | $312.5M | $0 | $529.5M |
| 44 | The Weld Trust Greeley | E | $262.4M | $35.2M | $578.9M |
| 45 | Rocky Mountain Ufcw Unions & Employers Health Benefit Fund Arvada | Z | $260.2M | $138.1M | $52.6M |
| 46 | Colorado Gives Foundation Arvada | T | $246.4M | $115.2M | $527.1M |
| 47 | Credit Unions Chartered in the State of Colorado Denver | Z | $240.9M | $135.8M | $2.1B |
| 48 | Colorado State University Foundation Fort Collins | B | $239.4M | $96.9M | $790.0M |
| 49 | Uchealth Greeley Hospital Fort Collins | E | $238.5M | $238.3M | $222.5M |
| 50 | Credit Unions Chartered in the State of Colorado Broomfield | Z | $216.8M | $216.4M | $3.4B |