| 1 | Zoological Society of Philadelphia Philadelphia | $61.3M | $43.7M | $136.3M |
| 2 | Zoological Society of Pittsburgh Pittsburgh | $31.6M | $30.5M | $79.1M |
| 3 | Montgomery County Society for the Prevention of Cruelty to Animals Conshohocken | $25.1M | $7.0M | $73.1M |
| 4 | Brandywine Valley Society for the Prevention of Cruelty to Animals West Chester | $19.4M | $18.4M | $27.5M |
| 5 | Norristown Zoological Society Norristown | $17.8M | $16.1M | $71.4M |
| 6 | Pennsylvania Society for the Prevention of Cruelty to Animals Philadelphia | $17.3M | $14.3M | $33.2M |
| 7 | Humane Animal Rescue Pittsburgh | $14.4M | $10.8M | $18.9M |
| 8 | National Aviary Pittsburgh INC Pittsburgh | $12.6M | $10.8M | $25.4M |
| 9 | Animal Friends INC Pittsburgh | $11.9M | $10.0M | $30.0M |
| 10 | Akashinga INC Philadelphia | $9.1M | $9.1M | $9.9M |
| 11 | Animal Care and Control Team Philadelphia | $9.0M | $9.0M | $6.4M |
| 12 | Harold and Judy McKonly Family Foundation Columbia | $8.2M | $0 | $23.7M |
| 13 | American Anti-vivisection Society Jenkintown | $8.0M | $3.2M | $37.5M |
| 14 | Hawk Mountain Sanctuary Association Kempton | $7.9M | $7.6M | $33.1M |
| 15 | Delaware County Society for the Prev of Cruelty to Animals Media | $7.8M | $7.7M | $9.2M |
| 16 | Lehigh Valley Zoological Society Schnecksville | $7.5M | $7.0M | $6.6M |
| 17 | York County Society for the Prevention of Cruelty to Animals York | $7.4M | $4.3M | $9.9M |
| 18 | Womens Humane Society for the Prevention of Cruelty to Animals Bensalem | $6.9M | $4.0M | $16.3M |
| 19 | Philadelphia Animal Welfare Society Philadelphia | $6.6M | $5.8M | $6.4M |
| 20 | Erie Zoological Society Erie | $5.7M | $5.1M | $15.7M |
| 21 | Runnymede Sanctuary Ua of Diana S Wister 08052013 Tr Coatesville | $5.5M | $0 | $91.9M |
| 22 | Humane Pennsylvania Reading | $5.3M | $5.2M | $13.4M |
| 23 | Society for Prevention of Cruelty to Animals of Luzerne County Wilkes Barre | $5.2M | $1.5M | $17.2M |
| 24 | Linda Rambler Conservancy Trust Hershey | $5.0M | $0 | $5.0M |
| 25 | Bucks County Society for Prevention of Cruelty to Animals New Hope | $4.8M | $4.4M | $15.8M |
| 26 | Alternatives for Research and Development Foundation Jenkintown | $4.5M | $2.1M | $16.8M |
| 27 | International Seafood Sustainability Foundation Pittsburgh | $4.5M | $4.5M | $2.1M |
| 28 | Francisvale Home for Smaller Animals Radnor | $4.4M | $1.1M | $7.7M |
| 29 | Lehigh County Humane Society Allentown | $4.4M | $3.7M | $9.9M |
| 30 | Bridge Clinic INC Bensalem | $4.4M | $4.4M | $1.9M |
| 31 | Animal Rescue League of Berks County INC Birdsboro | $4.4M | $4.3M | $7.4M |
| 32 | The Spayed Club Broomall | $3.8M | $1.5M | $12.6M |
| 33 | Beaver County Humane Society Aliquippa | $3.8M | $3.7M | $5.9M |
| 34 | Hillside Society for the Prevention of Cruelty to Animals Pottsville | $3.4M | $1.3M | $3.2M |
| 35 | Waverly Senior Services Gladwyne | $3.0M | $3.0M | $1.9M |
| 36 | 1LOVE4ANIMALS INC Southeastern | $2.9M | $2.9M | $4.1M |
| 37 | Healthy Kids Running Series Chadds Ford | $2.8M | $2.8M | $731K |
| 38 | Leg Up Farm INC Mount Wolf | $2.7M | $2.6M | $15.7M |
| 39 | Little Longears Mini Donkey Rescue New Oxford | $2.6M | $2.6M | $2.7M |
| 40 | The Center for Animal Health and Welfare Easton | $2.6M | $1.5M | $5.0M |
| 41 | National Greyhound Adoption Program INC Philadelphia | $2.6M | $2.6M | $4.1M |
| 42 | Northwestern Pennsylvania Humane Society Erie | $2.6M | $1.6M | $3.2M |
| 43 | Animal Care Fund E Smithfield | $2.5M | $2.5M | $7.5M |
| 44 | Lever Foundation Growth Fund Lancaster | $2.5M | $2.5M | $4.0M |
| 45 | Delaware Valley Golden Retriever Rescue INC Reinholds | $2.4M | $1.9M | $5.3M |
| 46 | Humane Society of Lackawanna County S Abingtn Twp | $2.3M | $1.5M | $4.7M |
| 47 | Animal Welfare Council of the Alleghenies Woodland | $2.3M | $2.3M | $456K |
| 48 | Washington Area Humane Society Eighty Four | $2.3M | $2.2M | $6.5M |
| 49 | Lever Foundation INC Lancaster | $2.3M | $2.3M | $3.0M |
| 50 | Anna Foundation INC Erie | $2.2M | $2.2M | $285K |