| 1 | Kaiser Foundation Health Plan of Colorado Aurora, CO | $4.5B | $2.6B |
| 2 | Commonspirit Health Englewood, CO | $3.4B | $9.9B |
| 3 | Catholic Health Initiatives Colorado Centennial, CO | $3.3B | $6.1B |
| 4 | Childrens Hospital Colorado Aurora, CO | $2.0B | $2.4B |
| 5 | Portercare Adventist Health System Greenwood Village, CO | $1.8B | $1.8B |
| 6 | Poudre Valley Medical Group LLC Fort Collins, CO | $1.0B | $194.9M |
| 7 | Alliance for Sustainable Energy LLC Lakewood, CO | $1.0B | $232.2M |
| 8 | Poudre Valley Health Care INC Fort Collins, CO | $970.2M | $12.0B |
| 9 | University of Denver Denver, CO | $834.9M | $2.2B |
| 10 | Colorado Access Aurora, CO | $790.2M | $213.1M |
| 11 | Delta Dental of Colorado Greenwood Vlg, CO | $680.9M | $106.6M |
| 12 | Saint Joseph Hospital Denver, CO | $645.4M | $1.0B |
| 13 | Medical Center of the Rockies Fort Collins, CO | $642.0M | $750.7M |
| 14 | Credit Unions Chartered in the State of Colorado Colorado Springs, CO | $594.7M | $9.8B |
| 15 | Young Life Colorado Spgs, CO | $556.3M | $440.0M |
| 16 | Denver Health Medical Plan INC Denver, CO | $536.0M | $89.0M |
| 17 | Parkview Medical Center INC Pueblo, CO | $518.8M | $617.8M |
| 18 | Hexagon Foundation Colorado Spgs, CO | $506.0M | $522.9M |
| 19 | Credit Unions Chartered in the State of Colorado Greenwood Vlg, CO | $496.7M | $8.6B |
| 20 | United States Olympic & Paralympic Committee Colorado Springs, CO | $496.3M | $602.2M |
| 21 | University of Colorado Foundation Denver, CO | $456.1M | $3.5B |
| 22 | Commonspirit Mountain Region Centennial, CO | $418.4M | $431.9M |
| 23 | United Power INC Brighton, CO | $416.1M | $1.4B |
| 24 | Core Electric Cooperative Sedalia, CO | $413.2M | $1.4B |
| 25 | National Jewish Health Denver, CO | $401.1M | $414.0M |
| 26 | Vail Clinic INC Vail, CO | $389.3M | $853.2M |
| 27 | Valley View Hospital Association Glenwood Spgs, CO | $368.5M | $678.9M |
| 28 | Credit Unions Chartered in the State of Colorado Lone Tree, CO | $360.6M | $4.6B |
| 29 | Christian Community Foundation INC Colorado Spgs, CO | $337.6M | $746.4M |
| 30 | Colorado West Healthcare System Grand Jct, CO | $312.5M | $260.5M |
| 31 | University Corporation for Atmospheric Research Boulder, CO | $311.0M | $356.7M |
| 32 | Colorado College Th Colorado Spgs, CO | $294.1M | $1.5B |
| 33 | Uchealth Greeley Hospital Fort Collins, CO | $238.3M | $222.5M |
| 34 | Charter Fund INC Denver, CO | $232.4M | $720.3M |
| 35 | Credit Unions Chartered in the State of Colorado Broomfield, CO | $216.4M | $3.4B |
| 36 | Denver Foundation Denver, CO | $208.3M | $1.3B |
| 37 | Montrose Memorial Hospital Montrose, CO | $197.4M | $212.6M |
| 38 | Goodwill of Colorado Colorado Spgs, CO | $183.4M | $283.5M |
| 39 | Allosource Centennial, CO | $180.1M | $150.4M |
| 40 | Food Bank of the Rockies Aurora, CO | $174.0M | $155.2M |
| 41 | Regis University Denver, CO | $165.6M | $219.9M |
| 42 | Craig Hospital Englewood, CO | $164.8M | $380.2M |
| 43 | Rocky Mountain Institute Boulder, CO | $164.7M | $149.5M |
| 44 | Poudre Valley Rural Electric Association INC Fort Collins, CO | $163.4M | $337.8M |
| 45 | Commonspirit Kansas INC Centennial, CO | $163.3M | $222.7M |
| 46 | Holy Cross Electric Assoc INC Glenwood Spgs, CO | $159.4M | $391.5M |
| 47 | Colorado Christian University Lakewood, CO | $156.6M | $216.4M |
| 48 | Yampa Valley Medical Center Steamboat Spr, CO | $147.3M | $192.6M |
| 49 | Mental Health Center of Denver Denver, CO | $145.6M | $111.4M |
| 50 | Mountain View Electric Assoc INC Limon, CO | $144.7M | $514.0M |