| 1 | Novant Health INC Winston Salem | E | $7.8B | $6.5B | $14.6B |
| 2 | Duke University Health System INC Durham | E | $7.2B | $5.8B | $8.6B |
| 3 | State Chartered Credit Unions INC Raleigh | Z | $4.6B | $2.6B | $56.4B |
| 4 | Duke University Durham | B | $4.5B | $4.5B | $21.2B |
| 5 | Chancellor Masters & Scholars of the University of Oxford Cary | Z | $3.6B | $3.6B | $11.3B |
| 6 | North Carolina Baptist Hospital Winstonsalem | E | $3.3B | $3.3B | $2.8B |
| 7 | Wakemed Raleigh | E | $2.6B | $2.3B | $2.0B |
| 8 | Presbyterian Hospital Winston Salem | E | $2.3B | $2.3B | $4.8B |
| 9 | Samaritans Purse Boone | X | $2.3B | $1.8B | $2.6B |
| 10 | Pitt County Memorial Hospital INC Greenville | E | $2.1B | $2.1B | $1.7B |
| 11 | Gothic Corporation Durham | B | $1.8B | $1.8B | $8.2B |
| 12 | Rex Hospital INC Raleigh | E | $1.7B | $1.7B | $1.8B |
| 13 | Duke Endowment Charlotte | Z | $1.7B | $0 | $3.6B |
| 14 | Wake Forest University Health Sciences Winstonsalem | B | $1.7B | $1.7B | $2.2B |
| 15 | Forsyth Memorial Hospital INC Winston Salem | E | $1.6B | $1.6B | $3.2B |
| 16 | Research Triangle Institute Durham | U | $1.5B | $1.4B | $935.9M |
| 17 | Atlantic Coast Conference Charlotte | N | $1.4B | $711.4M | $274.0M |
| 18 | North Carolina Electric Membership Corporation Raleigh | Y | $1.3B | $1.3B | $2.4B |
| 19 | Duke Health Integrated Practice INC Durham | Z | $1.3B | $1.3B | $249.1M |
| 20 | Nc State Investment Fund INC Raleigh | B | $1.3B | $304.3M | $2.5B |
| 21 | First Health of the Carolinas INC Pinehurst | E | $1.2B | $1.2B | $1.7B |
| 22 | Wake Forest University Winstonsalem | B | $1.2B | $764.4M | $2.8B |
| 23 | Educational Testing Service Charlotte | B | $1.1B | $1.1B | $1.7B |
| 24 | North Carolina Insurance Raleigh | Z | $956.3M | $570.8M | $1.8B |
| 25 | Family Health International Durham | Q | $800.1M | $800.0M | $348.3M |
| 26 | Dogwood Health Trust Asheville | T | $797.1M | $0 | $2.0B |
| 27 | Gaston Memorial Hospital INC Gastonia | E | $791.1M | $790.9M | $895.1M |
| 28 | Campbell University Buies Creek | B | $766.0M | $231.3M | $653.9M |
| 29 | Foundation for the Carolinas Charlotte | T | $761.6M | $761.4M | $3.9B |
| 30 | The Moses H Cone Memorial Hospital Operating Corporation Greensboro | E | $622.2M | $598.6M | $2.0B |
| 31 | East Carolina Health Greenville | E | $597.3M | $596.8M | $383.7M |
| 32 | Burroughs Wellcome Fund Rtp | T | $542.0M | $0 | $848.0M |
| 33 | Sandhills Center for Mental Health Developmental Disabilities & Subst West End | F | $533.5M | $532.9M | $251.2M |
| 34 | High Point University High Point | B | $512.4M | $489.7M | $1.2B |
| 35 | High Point Regional Health High Point | E | $502.9M | $502.9M | $487.6M |
| 36 | Gothic Hsp Corporation Durham | E | $490.2M | $490.2M | $2.5B |
| 37 | Davidson College Davidson | B | $488.7M | $270.0M | $1.9B |
| 38 | Atrium Health Foundation Charlotte | E | $471.4M | $150.1M | $556.7M |
| 39 | The Leon Levine Foundation Charlotte | Z | $454.8M | $0 | $1.1B |
| 40 | Elon University Elon | B | $428.7M | $413.0M | $1.2B |
| 41 | North Carolina Community Foundation INC Raleigh | T | $414.6M | $143.7M | $569.1M |
| 42 | University Health Systems of Eastern Carolina INC Greenville | E | $401.4M | $401.3M | $508.4M |
| 43 | Cumberland County Hospital System INC Fayetteville | E | $396.0M | $346.9M | $1.8B |
| 44 | L C Ind INC Durham | P | $393.8M | $359.2M | $237.3M |
| 45 | Wayne Memorial Hospital INC Goldsboro | E | $382.2M | $382.1M | $515.2M |
| 46 | Blue Ridge Healthcare Hospitals INC Morganton | E | $365.3M | $334.0M | $723.5M |
| 47 | Group Health Program of the Natnl Telecommunications Coop Assoc Asheville | E | $353.3M | $353.3M | $332.5M |
| 48 | Bissell Ballantyne Legacy Foundation Charlotte | T | $351.8M | $0 | $183.0M |
| 49 | Vidant Medical Group LLC Greenville | E | $336.6M | $336.6M | $91.2M |
| 50 | Southeastern Regional Medical Center Lumberton | E | $334.3M | $334.3M | $333.9M |