| 1 | Christus Santa Rosa Health Care Corporation | Health Care | $1.2B | $966.7M |
| 2 | Southwest Research Institute | Science & Technology | $927.2M | $1.1B |
| 3 | Methodist Healthcare Ministries of South Texas INC | Health Care | $580.0M | $2.2B |
| 4 | Somerset Academy INC | Education | $498.4M | $640.9M |
| 5 | Trinity University | Education | $472.4M | $2.3B |
| 6 | Compass Connections | Human Services | $434.3M | $28.8M |
| 7 | Family Endeavors INC | Unclassified | $408.3M | $279.0M |
| 8 | Barrio Comprehensive Family Health Care Center INC | Health Care | $397.4M | $191.7M |
| 9 | University of the Incarnate Word | Education | $339.3M | $562.3M |
| 10 | San Antonio Area Foundation | Philanthropy, Voluntarism & Grantmaking | $308.1M | $640.7M |
| 11 | St. Marys University of San Antonio | Unclassified | $258.4M | $418.4M |
| 12 | Catholic Life Insurance | Unclassified | $244.4M | $1.2B |
| 13 | San Antonio Food Bank INC | Unclassified | $217.6M | $112.8M |
| 14 | Comprehensive Health Insurance Association | Unclassified | $171.7M | $199.1M |
| 15 | Alamo Workforce Development INC | Employment | $171.2M | $37.9M |
| 16 | Albert & Bessie Mae Kronkosky Char Fndtn 3005500-3136454 | Unclassified | $170.8M | $368.3M |
| 17 | Riverwalk Education Foundation INC | Education | $141.9M | $441.9M |
| 18 | Harvey E Najim Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $140.6M | $113.4M |
| 19 | Great Hearts America-texas | Environment | $137.6M | $354.5M |
| 20 | Qualtex Laboratories | Health Care | $128.5M | $118.0M |
| 21 | Texas Biomedical Research Institute | Medical Research | $103.3M | $366.6M |
| 22 | El Centro Del Barrio INC | Human Services | $97.6M | $114.8M |
| 23 | Jubilee Academic Center INC | Education | $94.0M | $186.0M |
| 24 | San Antonio Lighthouse for the Blind | Human Services | $92.9M | $70.0M |
| 25 | Goodwill Industries of San Antonio | Unclassified | $92.5M | $118.7M |
| 26 | Mays Family Foundation | Unclassified | $90.8M | $312.5M |
| 27 | Alamo Trust INC | Arts, Culture & Humanities | $87.5M | $55.3M |
| 28 | Impetus Foundation | Philanthropy, Voluntarism & Grantmaking | $86.2M | $274.9M |
| 29 | South Texas Blood & Tissue Center | Health Care | $85.1M | $46.6M |
| 30 | Firstmark Credit Union | Unclassified | $82.2M | $1.2B |
| 31 | Our Lady of the Lake University of San Antonio | Education | $80.9M | $110.0M |
| 32 | Greehey Family Foundation | Philanthropy, Voluntarism & Grantmaking | $74.3M | $173.5M |
| 33 | Elma Dill Russell Spencer Foundation | Unclassified | $72.8M | $105.5M |
| 34 | San Antonio Zoological Society INC | Animal-Related | $71.5M | $138.6M |
| 35 | Basis Texas Charter Schools INC | Education | $69.3M | $246.5M |
| 36 | Firstday Foundation | Human Services | $68.5M | $868.1M |
| 37 | Avance INC | Community Improvement & Capacity Building | $65.9M | $16.4M |
| 38 | Kate Marmion Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $64.1M | $663.0M |
| 39 | Bio Bridge | Health Care | $61.4M | $83.2M |
| 40 | Ewing Halsell Foundation | Philanthropy, Voluntarism & Grantmaking | $61.2M | $154.3M |
| 41 | United Way of San Antonio & Bexar County | Philanthropy, Voluntarism & Grantmaking | $57.2M | $83.7M |
| 42 | Saint Marys Hall INC | Education | $56.1M | $127.5M |
| 43 | San Antonio Livestock Exposition INC | Recreation & Sports | $54.8M | $71.4M |
| 44 | Operation Homefront INC | Community Improvement & Capacity Building | $54.6M | $54.3M |
| 45 | McS Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $54.4M | $157.9M |
| 46 | Compass Rose Education INC | Education | $52.9M | $170.6M |
| 47 | Goodwill Industries of San Antonio Contract Services | Human Services | $48.3M | $34.7M |
| 48 | Refugee & Immigrant Center for Education & Legal Services | Civil Rights, Social Action & Advocacy | $42.8M | $50.4M |
| 49 | Morningside Ministries | Human Services | $42.8M | $183.9M |
| 50 | Texas Organ Sharing Alliance | Unclassified | $40.8M | $50.8M |
| 51 | Southwest Research Institute Voluntary Ees Beneficiary Associat | Unclassified | $39.5M | $4.6M |
| 52 | Auditory Learning Foundation | Diseases, Disorders & Medical Disciplines | $39.3M | $181.3M |
| 53 | Training Rehabilitation & Development Institute INC | Employment | $39.2M | $28.6M |
| 54 | Young Mens Christian Association of Greater San Antonio | Unclassified | $38.7M | $50.7M |
| 55 | Southwest Texas Regional Advisory Council for Trauma | Health Care | $38.3M | $22.7M |
| 56 | Clarity Child Guidance Center | Mental Health & Crisis Intervention | $37.7M | $43.1M |
| 57 | Apple Orchard | Food, Agriculture & Nutrition | $37.0M | $77.1M |
| 58 | The Army Retirement Residence Foundation - San Antonio | Human Services | $35.7M | $5.9M |
| 59 | Petco Love | Philanthropy, Voluntarism & Grantmaking | $35.4M | $25.1M |
| 60 | American Payroll Institute INC | Unclassified | $34.9M | $53.6M |
| 61 | Bcfs Health and Human Services | Human Services | $34.8M | $22.2M |
| 62 | The Usaa Foundation INC | Philanthropy, Voluntarism & Grantmaking | $34.5M | $130.2M |
| 63 | Housing and Community Services INC | Housing & Shelter | $34.0M | $153.2M |
| 64 | Central Texas Regional Water Supply Corporation | Unclassified | $33.8M | $751.2M |
| 65 | Hermann Sons Life | Unclassified | $33.8M | $258.2M |
| 66 | San Antonio Country Club | Recreation & Sports | $33.7M | $52.4M |
| 67 | Family Service Association | Human Services | $33.7M | $34.4M |
| 68 | Haven for Hope of Bexar County | Housing & Shelter | $33.5M | $102.0M |
| 69 | Robert J Kleberg Jr and Helen C Kleberg Foundation | Unclassified | $33.0M | $242.6M |
| 70 | Soldiers Angels | Public Safety, Disaster Preparedness & Relief | $32.6M | $6.3M |
| 71 | John L Santikos Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $32.6M | $487.7M |
| 72 | Tres Grace Family Foundation | Philanthropy, Voluntarism & Grantmaking | $32.6M | $126.5M |
| 73 | John G Kenedy Jr Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $32.5M | $159.6M |
| 74 | Valero Energy Foundation | Philanthropy, Voluntarism & Grantmaking | $32.0M | $19.1M |
| 75 | Habitat for Humanity of San Antonio INC | Housing & Shelter | $31.8M | $47.2M |
| 76 | Semmes Foundation INC | Unclassified | $31.4M | $14.9M |
| 77 | Tejemos Foundation | Philanthropy, Voluntarism & Grantmaking | $30.9M | $51.7M |
| 78 | Visit San Antonio | Community Improvement & Capacity Building | $30.2M | $14.8M |
| 79 | Disability Services of the Southwest | Human Services | $30.0M | $27.7M |
| 80 | Max and Minnie Tomerlin Voelcker Fund | Philanthropy, Voluntarism & Grantmaking | $29.5M | $58.7M |
| 81 | Remember the Alamo Foundation | Arts, Culture & Humanities | $28.9M | $47.8M |
| 82 | Texas Agricultural Land Trust | Environment | $28.4M | $8.0M |
| 83 | Bible Study Fellowship | Religion-Related | $27.4M | $19.1M |
| 84 | Bst Senior Living West INC | Unclassified | $27.1M | $129.7M |
| 85 | Liftfund INC | Community Improvement & Capacity Building | $27.0M | $103.0M |
| 86 | Alamo Area Resource Center INC | Diseases, Disorders & Medical Disciplines | $26.7M | $18.2M |
| 87 | Safari Club International Foundatio | Animal-Related | $26.6M | $48.9M |
| 88 | San Antonio Bowl Association INC | Unclassified | $26.0M | $33.6M |
| 89 | John R & Greli N Less Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $25.8M | $127.3M |
| 90 | Communities in Schools of San Antonio | Education | $25.8M | $25.8M |
| 91 | Army Retirement Residence Supporting Foundation | Housing & Shelter | $25.3M | $186.1M |
| 92 | Innovative Network of Knowledge | Youth Development | $25.2M | $4.9M |
| 93 | Diamond Bar Fund | Food, Agriculture & Nutrition | $25.1M | $251.8M |
| 94 | United Texas Credit Union | Unclassified | $24.0M | $416.8M |
| 95 | Hispanic Association of Colleges and Universities | Education | $23.9M | $19.9M |
| 96 | Mission Road Developmental Center | Human Services | $23.9M | $27.0M |
| 97 | Hhi Services INC | Human Services | $23.9M | $4.0M |
| 98 | George W Brackenridge Foundation | Unclassified | $23.8M | $50.1M |
| 99 | Christus Childrens Foundation | Health Care | $22.8M | $70.8M |
| 100 | American Gi Forum National Veterans Outreach Program INC | Unclassified | $22.5M | $19.6M |