| 1 | Shannon Medical Center | Health Care | $742.2M | $562.5M |
| 2 | Shannon Clinic | Health Care | $299.9M | $71.1M |
| 3 | Shannon Medical Management | Health Care | $113.6M | $594K |
| 4 | Shannon West Texas Memorial Hospital | Health Care | $76.7M | $631.0M |
| 5 | San Angelo Area Foundation | Philanthropy, Voluntarism & Grantmaking | $70.9M | $273.2M |
| 6 | Concho Valley Electric Cooperative INC | Unclassified | $51.7M | $162.2M |
| 7 | Tlc Academy | Education | $49.9M | $68.1M |
| 8 | Shannon Business Services INC | Health Care | $32.6M | $9.2M |
| 9 | San Angelo Health Foundation | Health Care | $24.4M | $59.8M |
| 10 | Concho Valley Center for Human Advancement | Mental Health & Crisis Intervention | $15.2M | $10.4M |
| 11 | Angelo State University Foundation INC | Education | $13.4M | $48.8M |
| 12 | Foundation for Truth | Philanthropy, Voluntarism & Grantmaking | $13.0M | $60.5M |
| 13 | Shannon Real Estate Services | Health Care | $12.3M | $156.2M |
| 14 | Mary Ellen Kent Bunyard Family Foundation | Philanthropy, Voluntarism & Grantmaking | $12.3M | $11.9M |
| 15 | West Texas Lighthouse for the Blind | Unclassified | $11.3M | $14.7M |
| 16 | La Esperanza Clinic INC | Human Services | $10.5M | $12.7M |
| 17 | Concho Valley Workforce Development Board | Employment | $9.4M | $1.7M |
| 18 | Robert G Carr & Nona K Carr Scholarship Foundation | Education | $8.2M | $181.0M |
| 19 | San Angelo Stock Show & Rodeo Foundation | Education | $8.0M | $24.7M |
| 20 | Rio Concho INC | Unclassified | $8.0M | $20.4M |
| 21 | James B and Lois R Archer Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $7.8M | $37.8M |
| 22 | West Texas Counseling & Guidance INC | Mental Health & Crisis Intervention | $7.0M | $11.4M |
| 23 | San Angelo Stock Show & Rodeo Association INC | Unclassified | $6.8M | $13.5M |
| 24 | San Angelo Country Club INC | Unclassified | $5.3M | $5.9M |
| 25 | Concho Valley Community Action Agency | Unclassified | $4.8M | $807K |
| 26 | Alcohol & Drug Abuse Council for the Concho Valley | Unclassified | $4.4M | $6.8M |
| 27 | West Texas Boys Ranch | Unclassified | $3.7M | $30.2M |
| 28 | Young Mens Christian Association of San Angelo Texas | Human Services | $3.3M | $11.7M |
| 29 | Trans Texas Southwest Credit Union | Unclassified | $3.3M | $50.1M |
| 30 | Galilee Community Development | Housing & Shelter | $3.1M | $3.3M |
| 31 | Institute of Cognitive Development INC | Unclassified | $3.0M | $1.9M |
| 32 | The Childrens Advocacy Center of Greater West Texas INC | Civil Rights, Social Action & Advocacy | $2.9M | $10.0M |
| 33 | Shannon Health System | Health Care | $2.7M | $29.4M |
| 34 | Cornerstone Christian School | Education | $2.7M | $4.4M |
| 35 | San Angelo Museum of Fine Arts | Arts, Culture & Humanities | $2.4M | $9.1M |
| 36 | San Angelo Chamber of Commerce | Unclassified | $2.3M | $783K |
| 37 | Meals for the Elderly | Unclassified | $2.2M | $4.2M |
| 38 | Rio Concho Manor INC | Housing & Shelter | $1.8M | $1.5M |
| 39 | San Angelo Symphony Society | Unclassified | $1.8M | $2.0M |
| 40 | Art and Eva Camunez Tucker Foundation | Unclassified | $1.8M | $10.6M |
| 41 | American Boer Goat Association | Unclassified | $1.6M | $2.3M |
| 42 | Shook Charitable Trust | Human Services | $1.5M | $7.5M |
| 43 | Concho Valley Regional Food Bank of Texas INC | Unclassified | $1.5M | $3.2M |
| 44 | West Texas Boys Ranch Foundation | Human Services | $1.4M | $27.2M |
| 45 | San Angelo Christian Academy | Education | $1.4M | $788K |
| 46 | Concho Valley Credit Union | Unclassified | $1.1M | $23.3M |
| 47 | Humane Society of Tom Green County | Animal-Related | $1.1M | $1.1M |
| 48 | San Angelo Performing Arts Coalition INC | Arts, Culture & Humanities | $1.1M | $19.1M |
| 49 | United Way of the Concho Valley INC | Philanthropy, Voluntarism & Grantmaking | $1.0M | $3.1M |
| 50 | Texas J Regional Advisory Council 10021998 | Health Care | $1.0M | $877K |
| 51 | San Angelo Day Nursery Charitable Foundation INC | Human Services | $1.0M | $919K |
| 52 | Village East Retirement Communityinc | Housing & Shelter | $983K | $8.5M |
| 53 | House of Faith-san Angelo | Religion-Related | $977K | $577K |
| 54 | Pregnancy Help Center of Concho Valley INC | Human Services | $933K | $2.3M |
| 55 | Christians in Action INC | Human Services | $929K | $813K |
| 56 | Boy Scouts of America | Unclassified | $913K | $1.3M |
| 57 | Benevolent & Protective Order of Elks of the USA | Unclassified | $872K | $435K |
| 58 | Safari Club International | Unclassified | $850K | $520K |
| 59 | Concho Valley Economic Development District Incorporated | Unclassified | $721K | $884K |
| 60 | Cassies Place INC | Animal-Related | $701K | $301K |
| 61 | Massey Fender Endowment Fund | Religion-Related | $679K | $4.7M |
| 62 | San Angelo Civic Ballet Incorporated | Unclassified | $632K | $543K |
| 63 | La Gran Familia Ministries INC | Human Services | $624K | $932K |
| 64 | Concho Valley Regional Advisory Council Tsa-k | Health Care | $609K | $446K |
| 65 | San Angelo National Community Foundation | Philanthropy, Voluntarism & Grantmaking | $607K | $624K |
| 66 | Diamond M Foundation INC | Unclassified | $603K | $6.5M |
| 67 | Boys & Girls Club of San Angelo INC | Unclassified | $591K | $665K |
| 68 | Earnest and Dorthy Barrow Foundation | Unclassified | $563K | $7.6M |
| 69 | Ross & Evelyn Daniels Charitable Tr | Unclassified | $562K | $3.4M |
| 70 | Concho Valley Home for Girls INC | Unclassified | $525K | $1.1M |
| 71 | Judge Raymond Fuller Charitable Test Tr | Philanthropy, Voluntarism & Grantmaking | $505K | $2.7M |
| 72 | Gather1 | International, Foreign Affairs & National Security | $494K | $82K |
| 73 | Shannon West Texas Memorial Hospital Auxiliary INC | Health Care | $455K | $641K |
| 74 | San Angelo Braodway Academy Youth Theatre | Arts, Culture & Humanities | $453K | $31K |
| 75 | Open Arms Rape Crisis Center & Lgbt Services | Community Improvement & Capacity Building | $449K | $434K |
| 76 | Concho Valley Turning Point | Mental Health & Crisis Intervention | $427K | $597K |
| 77 | The Whit Program INC | Unclassified | $411K | $324K |
| 78 | Texas Sheep & Goat Raisers Assoc | Unclassified | $409K | $537K |
| 79 | Concho Christmas Celebration INC | Arts, Culture & Humanities | $407K | $132K |
| 80 | West Texas Gospel Ministries to Children INC | Religion-Related | $404K | $386K |
| 81 | Sonrisas Therapeutic Riding INC | Recreation & Sports | $402K | $998K |
| 82 | Habitat for Humanity International INC | Unclassified | $400K | $865K |
| 83 | Sheep and Goat Validation of Texas | Food, Agriculture & Nutrition | $396K | $486K |
| 84 | Fresh Start of San Angelo | Human Services | $392K | $62K |
| 85 | Potters Hand Christian School | Education | $389K | $192K |
| 86 | Little League Baseball INC | Unclassified | $383K | $199K |
| 87 | The Baize Gospel Preaching Foundation | Philanthropy, Voluntarism & Grantmaking | $364K | $380K |
| 88 | Angelo State University Ex-students Association | Unclassified | $354K | $1.7M |
| 89 | West Texas Christian Ministries | Religion-Related | $343K | $2.6M |
| 90 | Rust Street Ministries | Religion-Related | $331K | $2.7M |
| 91 | Supernatural Marriage Ministries | Religion-Related | $325K | $42K |
| 92 | Better Business Bureau of San Angelo INC | Unclassified | $315K | $477K |
| 93 | San Angelo Civic Theatre | Unclassified | $312K | $459K |
| 94 | Tom Green County Farm Bureau | Unclassified | $312K | $595K |
| 95 | Shriners International | Unclassified | $296K | $1.2M |
| 96 | Junior League of San Angelo INC | Community Improvement & Capacity Building | $288K | $860K |
| 97 | Concho Valley Biblical Counseling Center | Mental Health & Crisis Intervention | $279K | $320K |
| 98 | The James Phillips Williams Memorial Foundation | Unclassified | $257K | $464K |
| 99 | M C Shook Trust | Unclassified | $256K | $1.6M |
| 100 | Stribling Funding Corporation | Unclassified | $256K | $2.3M |