| 1 | Texas Health Presbyterian Hospital Plano | Health Care | $570.8M | $276.2M |
| 2 | North Texas Food Bank | Unclassified | $300.8M | $181.2M |
| 3 | Pure Hand for Mankind INC | International, Foreign Affairs & National Security | $214.0M | $8.9M |
| 4 | Medical and Life Benefits Plan Tr for Hourly Retirees | Mutual & Membership Benefit | $134.4M | $90.1M |
| 5 | Toyota Motor Sales USA INC Post-retirement Medical Trust | Mutual & Membership Benefit | $128.9M | $320.4M |
| 6 | Intouch Credit Union | Unclassified | $60.8M | $834.4M |
| 7 | The Legacy Midtown Park INC | Housing & Shelter | $34.5M | $162.2M |
| 8 | Human Coalition | Human Services | $31.5M | $17.9M |
| 9 | Marketplace Ministries INC | Religion-Related | $31.4M | $7.2M |
| 10 | The Legacy Willow Bend INC | Human Services | $26.6M | $76.2M |
| 11 | Altria Client Services Long-term Disability Trust | Unclassified | $26.4M | $43.5M |
| 12 | Feeding North Texas Foundation | Food, Agriculture & Nutrition | $23.7M | $29.6M |
| 13 | Good Start Foundation | Philanthropy, Voluntarism & Grantmaking | $23.4M | $44.7M |
| 14 | First Liberty Institute | Civil Rights, Social Action & Advocacy | $22.4M | $22.7M |
| 15 | E3 Partners Ministry | Religion-Related | $19.5M | $6.3M |
| 16 | Toyota USA Foundation | Unclassified | $17.6M | $156.3M |
| 17 | The Mission 316 Foundation | Philanthropy, Voluntarism & Grantmaking | $16.7M | $8.1M |
| 18 | Center for American and International Law | Education | $16.7M | $32.3M |
| 19 | Plano Sports Authority | Recreation & Sports | $15.9M | $27.1M |
| 20 | Corby and Jay Verdoorn Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $15.2M | $9.0M |
| 21 | Humaniti Foundation | International, Foreign Affairs & National Security | $13.6M | $1.4M |
| 22 | Community Hospital Corporation | Health Care | $13.5M | $42.2M |
| 23 | Cornerstone Credit Union League | Unclassified | $11.9M | $37.6M |
| 24 | Lu Family Foundation | Philanthropy, Voluntarism & Grantmaking | $11.7M | $9.3M |
| 25 | The Storehouse of Collin County | Community Improvement & Capacity Building | $11.5M | $2.1M |
| 26 | Amparo Foundation | Philanthropy, Voluntarism & Grantmaking | $11.0M | $26.4M |
| 27 | The Legacy at Home INC | Human Services | $11.0M | $2.3M |
| 28 | Crawley Memorial Hospital INC | Health Care | $10.7M | $55K |
| 29 | Chc Community Care LLC | Health Care | $10.7M | $5.1M |
| 30 | Craig Ranch Community Association | Community Improvement & Capacity Building | $10.4M | $11.4M |
| 31 | My Possibilities | Unclassified | $10.1M | $38.0M |
| 32 | John and Bonnie Strauss Foundation | Philanthropy, Voluntarism & Grantmaking | $9.3M | $12.9M |
| 33 | Horizon Foundation | Philanthropy, Voluntarism & Grantmaking | $8.5M | $25.5M |
| 34 | Childrens Advocacy Center of Collin County INC | Civil Rights, Social Action & Advocacy | $8.1M | $22.0M |
| 35 | Hope for the Heart | Unclassified | $7.6M | $3.1M |
| 36 | Sudanese American Physicians Association | International, Foreign Affairs & National Security | $7.3M | $2.4M |
| 37 | Westerman Foundation | Philanthropy, Voluntarism & Grantmaking | $6.7M | $35.7M |
| 38 | Fisher Global Foundation | Philanthropy, Voluntarism & Grantmaking | $6.7M | $2.7M |
| 39 | Orphan Outreach | International, Foreign Affairs & National Security | $6.4M | $4.2M |
| 40 | National Charity League INC | Unclassified | $6.1M | $9.3M |
| 41 | Minnies Food Pantry INC | Food, Agriculture & Nutrition | $5.9M | $9.2M |
| 42 | Nonpareil Institute | Human Services | $5.9M | $4.6M |
| 43 | Renewable Energy for Better Life Foundation | Environment | $5.7M | $1.5M |
| 44 | S-g Owners Association INC | Philanthropy, Voluntarism & Grantmaking | $5.6M | $6.4M |
| 45 | Powerpoint Ministries | Religion-Related | $5.4M | $2.1M |
| 46 | North Texas Performing Arts | Arts, Culture & Humanities | $5.3M | $3.0M |
| 47 | Chc Community Care LLC | Health Care | $5.1M | $4.9M |
| 48 | Montessori New Beginnings Academy INC | Education | $4.9M | $13.2M |
| 49 | Alfred W and Nancy M Jones Foundation | Philanthropy, Voluntarism & Grantmaking | $4.9M | $11.8M |
| 50 | Creative Learning 4 Kids INC | Education | $4.8M | $2.4M |
| 51 | St. Marks Medical Center | Health Care | $4.5M | $15.9M |
| 52 | Club Soccer INC | Recreation & Sports | $4.5M | $436K |
| 53 | Hope Center Foundation | Philanthropy, Voluntarism & Grantmaking | $4.4M | $42.4M |
| 54 | City House INC | Human Services | $4.4M | $7.2M |
| 55 | Servinghim Healthcare International Ministries | International, Foreign Affairs & National Security | $4.3M | $3.6M |
| 56 | Support for Educational and Economic Development | International, Foreign Affairs & National Security | $4.2M | $4.5M |
| 57 | Both Ends Believing INC | Human Services | $4.1M | $1.8M |
| 58 | Texas Muslim Womens Foundation INC | Human Services | $3.8M | $1.8M |
| 59 | Amazon Outreach INC | International, Foreign Affairs & National Security | $3.8M | $2.8M |
| 60 | Life Without Limbs | Human Services | $3.7M | $1.7M |
| 61 | Endtime INC | Unclassified | $3.6M | $8.0M |
| 62 | Junk for Joy INC | Arts, Culture & Humanities | $3.6M | $289K |
| 63 | Robert J Werra Foundation | Philanthropy, Voluntarism & Grantmaking | $3.5M | $21.8M |
| 64 | Don and Faith Martin Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.4M | $4.9M |
| 65 | Legacy Senior Communities INC | Arts, Culture & Humanities | $3.3M | $925K |
| 66 | Ward Family Foundation | Unclassified | $3.3M | $7.2M |
| 67 | Abutrab Foundation | Philanthropy, Voluntarism & Grantmaking | $3.1M | $409K |
| 68 | Iqa Foundation | Arts, Culture & Humanities | $3.1M | $8.5M |
| 69 | Free Code Camp INC | Science & Technology | $3.0M | $9.8M |
| 70 | Uncharted Ministries INC | Religion-Related | $2.9M | $1.0M |
| 71 | Reuter Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.8M | $6.0M |
| 72 | Property Owners Association of Pointe West INC | Housing & Shelter | $2.7M | $1.7M |
| 73 | The Jcpenney Foundation | Human Services | $2.6M | $4.7M |
| 74 | Rape Crisis Center of Collin County | Unclassified | $2.4M | $1.3M |
| 75 | Z&y Future Foundation | Education | $2.4M | $1.8M |
| 76 | Nina Jean Obel Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $2.3M | $1.9M |
| 77 | Kalman & Ida Wolens Foundation | Youth Development | $2.3M | $4.2M |
| 78 | Plano Symphony Orchestra Non-profit Corp. | Arts, Culture & Humanities | $2.3M | $1.9M |
| 79 | Baptist Standard Publishing Co | Religion-Related | $2.3M | $16.3M |
| 80 | Agape Resource & Assistance Center INC | Housing & Shelter | $2.3M | $5.7M |
| 81 | G R E a T Kids with Adhd a Texas Non-profit Corporation | Education | $2.2M | $4.1M |
| 82 | The Homeowners Association of Lone Star Ranch INC | Unclassified | $2.2M | $2.6M |
| 83 | North Texas State Soccer | Unclassified | $2.1M | $8.2M |
| 84 | Saif & Lubna Foundation | Philanthropy, Voluntarism & Grantmaking | $2.1M | $4.0M |
| 85 | Harvesters Reaching the Nations INC | Religion-Related | $2.0M | $1.4M |
| 86 | Cornerstone Credit Union Foundation | Education | $2.0M | $2.7M |
| 87 | Dallas Builders Association | Unclassified | $1.9M | $2.9M |
| 88 | Windmill Foundation | Philanthropy, Voluntarism & Grantmaking | $1.8M | $2.2M |
| 89 | Plano Balloon Festival INC | Recreation & Sports | $1.8M | $1.5M |
| 90 | City of Plano Swimmers INC | Unclassified | $1.8M | $2.0M |
| 91 | Plano Community Home Incorporated | Unclassified | $1.8M | $2.1M |
| 92 | The McH Foundation INC | Arts, Culture & Humanities | $1.7M | $20.2M |
| 93 | Emilys Place INC | Housing & Shelter | $1.7M | $4.1M |
| 94 | New Hope Education INC | Education | $1.7M | $67K |
| 95 | Prayer Closet | Religion-Related | $1.7M | $3.7M |
| 96 | Imagine Lone Star International Academy | Education | $1.6M | $2.0M |
| 97 | Usg United Scientific Group | Education | $1.6M | $132K |
| 98 | American Nicaraguan School | Education | $1.6M | $2K |
| 99 | St. Timothy Christian Academy | Education | $1.5M | $1.2M |
| 100 | Engage Hope Ministries | International, Foreign Affairs & National Security | $1.5M | $400K |