| 1 | Covenant Medical Center | Health Care | $565.1M | $684.9M |
| 2 | Methodist Childrens Hospital | Health Care | $471.5M | $651.5M |
| 3 | Alliance Credit Union | Unclassified | $319.6M | $617.9M |
| 4 | Covenant Medical Group | Health Care | $223.2M | $138.3M |
| 5 | South Plains Electric Cooperative INC | Unclassified | $170.5M | $563.8M |
| 6 | Texas Tech Foundation INC | Education | $124.1M | $938.1M |
| 7 | Covenant Health System | Health Care | $123.3M | $199.1M |
| 8 | Lubbock Heritage Hospital LLC | Health Care | $71.7M | $251.2M |
| 9 | Lubbock Christian University | Education | $66.9M | $148.4M |
| 10 | Helen Jones Foundation INC | Unclassified | $52.3M | $255.9M |
| 11 | Covenant Hospital Hobbs | Health Care | $51.2M | $113.4M |
| 12 | Grace Clinic of Lubbock | Health Care | $50.8M | $54.6M |
| 13 | Welborn-payne Endowment Trust | Unclassified | $40.9M | $74.1M |
| 14 | Ch Foundation | Unclassified | $37.1M | $175.3M |
| 15 | Carillon INC | Human Services | $30.8M | $57.2M |
| 16 | Community Foundation of West Texas | Philanthropy, Voluntarism & Grantmaking | $27.8M | $77.1M |
| 17 | South Plains Food Bank INC | Food, Agriculture & Nutrition | $25.9M | $30.3M |
| 18 | Lubbock Area United Way INC | Philanthropy, Voluntarism & Grantmaking | $24.4M | $15.3M |
| 19 | Community Health Center of Lubbock INC | Health Care | $20.2M | $19.7M |
| 20 | Lw Texas Construction Veba Trust Agreement | Mutual & Membership Benefit | $18.5M | $0 |
| 21 | Lubbock Economic Development Alliance INC | Community Improvement & Capacity Building | $16.9M | $56.3M |
| 22 | Hospice of Lubbock INC | Human Services | $16.0M | $28.6M |
| 23 | Lubbock Country Club INC | Human Services | $13.8M | $15.8M |
| 24 | Goodwill Industries of Lubbock INC | Employment | $12.8M | $12.5M |
| 25 | Lubbock Entertainment and Performing Arts Association | Arts, Culture & Humanities | $12.7M | $168.7M |
| 26 | Young Womens Christian Association of Lubbock Texas INC | Unclassified | $11.7M | $36.0M |
| 27 | Lone Star Defenders Office | Crime & Legal-Related | $11.0M | $6.2M |
| 28 | Lubbock Private Defenders Office INC | Crime & Legal-Related | $10.7M | $794K |
| 29 | The Don-kay-clay Cash Foundation | Philanthropy, Voluntarism & Grantmaking | $10.2M | $17.0M |
| 30 | Market Lubbock Economic Development Corporation | Community Improvement & Capacity Building | $9.4M | $12.7M |
| 31 | Covenant Physician Partners INC | Health Care | $9.4M | $17.2M |
| 32 | Covenant Health System Foundation | Health Care | $8.3M | $64.8M |
| 33 | Texas Tech Law School Foundation | Unclassified | $7.8M | $48.5M |
| 34 | Childrens Home of Lubbock and Family Service Agency INC | Human Services | $7.4M | $5.4M |
| 35 | Umc Foundation | Health Care | $7.0M | $55.4M |
| 36 | Texas Girls and Boys Ranch | Human Services | $6.7M | $7.2M |
| 37 | Lubbock County Expo Center INC | Education | $6.6M | $7.4M |
| 38 | Childrens Home Foundation | Philanthropy, Voluntarism & Grantmaking | $6.6M | $32.8M |
| 39 | Communities in Schools of the South Plains | Youth Development | $6.6M | $6.6M |
| 40 | Crofoot Family Foundation | Philanthropy, Voluntarism & Grantmaking | $6.4M | $5.3M |
| 41 | C and a McDonald Family Foundation | Philanthropy, Voluntarism & Grantmaking | $6.4M | $9.9M |
| 42 | Lubbock Christian School | Education | $5.8M | $17.4M |
| 43 | United Association of Journeymen & Apprentices of the Plumbing & Pipe | Unclassified | $5.6M | $3.9M |
| 44 | Thomas Wells Foundation | Philanthropy, Voluntarism & Grantmaking | $5.5M | $3.6M |
| 45 | Ballet Lubbock | Arts, Culture & Humanities | $5.1M | $10.2M |
| 46 | Texas Tech Alumni Association | Education | $5.1M | $19.1M |
| 47 | Science Spectrum | Arts, Culture & Humanities | $5.0M | $19.9M |
| 48 | Wire Hollow Education Innovation | Education | $4.7M | $4.9M |
| 49 | Asco Foundation | Philanthropy, Voluntarism & Grantmaking | $4.6M | $30.2M |
| 50 | Breedlove Foods INC | Human Services | $4.6M | $7.9M |
| 51 | Marion Moss Enterprises INC | Employment | $4.5M | $2.3M |
| 52 | Civic Lubbock INC | Arts, Culture & Humanities | $4.5M | $3.1M |
| 53 | Museum of Texas Tech University Association | Arts, Culture & Humanities | $4.3M | $6.0M |
| 54 | Ranching Heritage Association | Unclassified | $4.2M | $5.7M |
| 55 | National Sorghum Producers Association | Unclassified | $4.0M | $1.8M |
| 56 | Catholic Charities Diocese of Lubbock | Unclassified | $3.9M | $3.6M |
| 57 | Lubbock Meals on Wheels Foundation | Food, Agriculture & Nutrition | $3.8M | $13.2M |
| 58 | Lubbock Open Door | Religion-Related | $3.8M | $3.0M |
| 59 | R H Pickering Family Foundation | Philanthropy, Voluntarism & Grantmaking | $3.8M | $12.3M |
| 60 | Childrens Hope Residential Services INC | Human Services | $3.7M | $2.5M |
| 61 | Early Learning Center of Lubbock INC | Human Services | $3.7M | $1.3M |
| 62 | Hds Foundation | Philanthropy, Voluntarism & Grantmaking | $3.7M | $10.4M |
| 63 | Southcrest Christian School INC | Education | $3.5M | $2.2M |
| 64 | Womens Protective Services of Lubbock INC | Human Services | $3.4M | $2.3M |
| 65 | Rise Academy | Education | $3.3M | $4.2M |
| 66 | Ronald McDonald House Charities of the Southwest INC | Health Care | $3.2M | $6.4M |
| 67 | Wtab | Philanthropy, Voluntarism & Grantmaking | $3.2M | $2.6M |
| 68 | Lubbock Meals on Wheels INC | Food, Agriculture & Nutrition | $2.8M | $4.1M |
| 69 | The Grace Message | Religion-Related | $2.7M | $3.1M |
| 70 | St. Pauls on the Plains Episcopal Church Trust | Religion-Related | $2.7M | $748K |
| 71 | Lubbock Methodist Hospital System | Health Care | $2.7M | $3.5M |
| 72 | YWCA of Lubbock Legacy Fund INC | Philanthropy, Voluntarism & Grantmaking | $2.5M | $5.9M |
| 73 | Lubbock Young Womens Leader Foundation | Human Services | $2.5M | $11.2M |
| 74 | Lubbock Boys and Girls Club INC | Youth Development | $2.4M | $5.2M |
| 75 | Lifetime Independence for Everyone INC | Unclassified | $2.4M | $1.7M |
| 76 | Kpa Ministries INC | Education | $2.4M | $3.7M |
| 77 | Partners Resource Network | Human Services | $2.4M | $1.1M |
| 78 | Lubbock Childrens Health Clinic | Unclassified | $2.4M | $3.5M |
| 79 | Sibi Foundation | Religion-Related | $2.4M | $29.2M |
| 80 | Panhandle South Plains Fair Association | Unclassified | $2.3M | $6.2M |
| 81 | Lubbock Symphony Orchestra | Arts, Culture & Humanities | $2.2M | $6.4M |
| 82 | Lubbock Association of Realtors INC | Unclassified | $2.2M | $5.1M |
| 83 | The Louise Hopkins Underwood Center for the Arts | Arts, Culture & Humanities | $2.2M | $4.6M |
| 84 | Casa of the South Plains INC | Crime & Legal-Related | $2.0M | $1.6M |
| 85 | Lubbock Chamber of Commerce | Unclassified | $2.0M | $4.2M |
| 86 | Texas Home School Coalition INC | Education | $1.9M | $611K |
| 87 | James Nislar Foundation | Philanthropy, Voluntarism & Grantmaking | $1.9M | $8.3M |
| 88 | Saint Benedicts Chapel | Religion-Related | $1.9M | $398K |
| 89 | Lubbock Christian University Foundation | Education | $1.8M | $10.0M |
| 90 | International Association of Lions Clubs | Unclassified | $1.8M | $65K |
| 91 | Trinity Christian Schools Foundation | Unclassified | $1.8M | $4.3M |
| 92 | Terry and Kelly Crofoot Foundation | Philanthropy, Voluntarism & Grantmaking | $1.8M | $1K |
| 93 | High Point Village | Human Services | $1.7M | $5.5M |
| 94 | Gladys and Jd Leftwich Charitable Tr 2 | Philanthropy, Voluntarism & Grantmaking | $1.6M | $612K |
| 95 | Team Luke Hope for Minds | Diseases, Disorders & Medical Disciplines | $1.6M | $420K |
| 96 | Childrens Advocacy Center of the South Plains Texas INC | Crime & Legal-Related | $1.6M | $1.2M |
| 97 | Agriculture Heritage Museum INC | Arts, Culture & Humanities | $1.6M | $15.7M |
| 98 | Rotary Club of Lubbock Foundation | Philanthropy, Voluntarism & Grantmaking | $1.6M | $2.3M |
| 99 | American Legion 575 | Unclassified | $1.5M | $580K |
| 100 | United Association of Journeyman & Apprentices of the Plumbing & Pipe | Unclassified | $1.5M | $440K |