| 1 | Hendrick Medical Center | Health Care | $1.0B | $1.7B |
| 2 | Abilene Christian University | Unclassified | $682.9M | $1.3B |
| 3 | Karakin Foundation | Philanthropy, Voluntarism & Grantmaking | $143.0M | $193.7M |
| 4 | Hendrick Medical Center Brownwood | Health Care | $133.6M | $110.2M |
| 5 | Dian Graves Owen Foundation | Philanthropy, Voluntarism & Grantmaking | $111.7M | $194.8M |
| 6 | Hardin-simmons University | Education | $100.2M | $421.5M |
| 7 | Hendrick Provider Network | Health Care | $74.8M | $22.3M |
| 8 | Community Foundation of Abilene | Philanthropy, Voluntarism & Grantmaking | $67.7M | $204.3M |
| 9 | McMurry University | Education | $60.1M | $193.3M |
| 10 | Kickapoo Springs Foundation | Philanthropy, Voluntarism & Grantmaking | $42.4M | $111.0M |
| 11 | The West Texas Rehabilitation Center | Health Care | $42.3M | $48.0M |
| 12 | Legett Foundation | Philanthropy, Voluntarism & Grantmaking | $42.2M | $111.6M |
| 13 | Abilene Goodwill Industries INC | Employment | $21.9M | $30.5M |
| 14 | New Horizons Ranch and Center INC | Unclassified | $18.5M | $10.7M |
| 15 | West Texas Rehabilitation Center Foundation | Health Care | $16.4M | $212.7M |
| 16 | Hendrick Anethesia Network | Health Care | $15.3M | $932K |
| 17 | Abilene Country Club INC | Unclassified | $14.8M | $16.4M |
| 18 | Abilene Heritage Square INC | Arts, Culture & Humanities | $14.3M | $91.6M |
| 19 | Wesley Court LLC | Human Services | $13.4M | $76.5M |
| 20 | Hendrick Hospice Care INC | Human Services | $12.8M | $29.8M |
| 21 | Hendrick Medical Center Foundation | Health Care | $12.7M | $80.4M |
| 22 | Chc Community Care LLC | Health Care | $11.2M | $5.0M |
| 23 | Food Bank of Abilene INC | Food, Agriculture & Nutrition | $10.5M | $14.9M |
| 24 | Dodge Jones Legacy Foundation | Philanthropy, Voluntarism & Grantmaking | $10.4M | $27.3M |
| 25 | Meals on Wheels Plus Incorporated | Food, Agriculture & Nutrition | $9.5M | $23.5M |
| 26 | Hendrick Home for Children | Unclassified | $7.8M | $169.1M |
| 27 | Serenity Foundation of Texas | Mental Health & Crisis Intervention | $7.6M | $10.1M |
| 28 | All Kind Animal Initiative | Animal-Related | $7.6M | $13.4M |
| 29 | Expo Center of Taylor County | Recreation & Sports | $7.0M | $2.5M |
| 30 | Day Nursery of Abilene | Unclassified | $6.2M | $12.0M |
| 31 | Abilene Chamber of Commerce | Unclassified | $5.8M | $4.8M |
| 32 | Abilene Christian Schools INC | Education | $5.6M | $20.3M |
| 33 | Abilene Zoological Society | Animal-Related | $5.0M | $732K |
| 34 | Love & Care Ministries | Human Services | $4.5M | $7.0M |
| 35 | Christian Homes of Abilene | Human Services | $4.1M | $9.8M |
| 36 | Zambia Christian College Incorporated | International, Foreign Affairs & National Security | $4.0M | $2.6M |
| 37 | Potosi Water Supply Corporation | Unclassified | $3.9M | $11.3M |
| 38 | United Way of Abilene | Unclassified | $3.5M | $4.3M |
| 39 | Tecumseh Foundation | Philanthropy, Voluntarism & Grantmaking | $3.4M | $32.3M |
| 40 | Disability Resources INC | Human Services | $3.2M | $13.8M |
| 41 | Hmc Hospice Properties | Health Care | $3.2M | $130K |
| 42 | Grace Museum INC | Arts, Culture & Humanities | $3.2M | $9.6M |
| 43 | Young Mens Christian Association of Abilene | Human Services | $2.7M | $10.1M |
| 44 | Veterans of Foreign Wars of the United States Dept of Texas | Unclassified | $2.7M | $2.2M |
| 45 | West Central Texas Regional Foundation | Human Services | $2.5M | $217K |
| 46 | Eleemosynary St. John Episcopal School of Abilene INC | Unclassified | $2.4M | $4.3M |
| 47 | W P & Dell Andrews Newell Charitable Trust | Unclassified | $2.3M | $11.9M |
| 48 | Whitener Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.2M | $10.0M |
| 49 | First Baptist Mission Action INC | Human Services | $2.2M | $136K |
| 50 | Abilene Recovery Council | Mental Health & Crisis Intervention | $2.2M | $340K |
| 51 | Dignity Health Management Center INC | Diseases, Disorders & Medical Disciplines | $2.2M | $1.9M |
| 52 | Acimco | Education | $2.2M | $600K |
| 53 | Noah Project INC | Unclassified | $2.1M | $3.3M |
| 54 | Historic Paramount Theatre INC | Arts, Culture & Humanities | $2.1M | $1.5M |
| 55 | Grace L Woodward Memorial Endowment Trust | Unclassified | $2.1M | $48.0M |
| 56 | Directors Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.0M | $283K |
| 57 | Abilene Restoration Ministries | Mental Health & Crisis Intervention | $2.0M | $2.1M |
| 58 | South Taylor Emergency Medical Service | Unclassified | $2.0M | $1.5M |
| 59 | Timothy International | Religion-Related | $2.0M | $468K |
| 60 | Rwanda Children | Unclassified | $1.9M | $522K |
| 61 | Boy Scouts of America | Unclassified | $1.8M | $4.5M |
| 62 | Beltway Ministry Center INC | Human Services | $1.8M | $85K |
| 63 | Global Samaritan Resources INC | International, Foreign Affairs & National Security | $1.8M | $1.7M |
| 64 | New Horizons Ranch & Center Foundation | Unclassified | $1.6M | $14.8M |
| 65 | Veterans of Foreign Wars of the US Dept of Texas Auxiliary | Unclassified | $1.5M | $291K |
| 66 | Alliance for Women and Children | Human Services | $1.5M | $4.7M |
| 67 | Abilene Youth Sports Authority INC | Youth Development | $1.4M | $31.4M |
| 68 | View-caps Water Supply Corporation | Unclassified | $1.4M | $4.1M |
| 69 | Communities in Schools of the Big Country | Education | $1.4M | $1.9M |
| 70 | View Volunteer Fire Dept | Public Safety, Disaster Preparedness & Relief | $1.4M | $571K |
| 71 | Pregnancy Resources of Abilene INC | Civil Rights, Social Action & Advocacy | $1.4M | $1.2M |
| 72 | Shelton Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.3M | $40.8M |
| 73 | League of United Latin America Citizens | Human Services | $1.3M | $66K |
| 74 | Abilene Boys Ranch INC | Human Services | $1.3M | $14.1M |
| 75 | Simpson Charitable Trust | Unclassified | $1.3M | $4.5M |
| 76 | Abilene Opera Association INC | Arts, Culture & Humanities | $1.3M | $127K |
| 77 | West Central Texas Workforce Development Board INC | Employment | $1.3M | $671K |
| 78 | American Legion Auxiliary | Unclassified | $1.3M | $218K |
| 79 | United Way Foundation of Abilene | Philanthropy, Voluntarism & Grantmaking | $1.3M | $8.0M |
| 80 | Regional Crime Victim Crisis Center | Human Services | $1.2M | $1.3M |
| 81 | Boys & Girls Clubs of Abilene INC | Unclassified | $1.2M | $1.2M |
| 82 | Habitat for Humanity International INC | Housing & Shelter | $1.2M | $1.6M |
| 83 | Frontier Texas INC | Arts, Culture & Humanities | $1.2M | $7.7M |
| 84 | Dueser Foundation | Human Services | $1.2M | $739K |
| 85 | Presbyterian Medical Care Mission | Unclassified | $1.2M | $1.8M |
| 86 | Abilene Arts Alliance | Arts, Culture & Humanities | $1.2M | $2.8M |
| 87 | Big Country Court Appointed Special Advocates INC | Crime & Legal-Related | $1.2M | $2.9M |
| 88 | Mims Memorial Trust Formerly Anna Louise Mims Trust | Unclassified | $1.1M | $3.6M |
| 89 | Abilene Board of Realtors INC | Unclassified | $1.1M | $1.1M |
| 90 | First Priority Credit Union | Unclassified | $1.1M | $19.8M |
| 91 | Abilene Boys Ranch Foundation | Unclassified | $1.1M | $8.5M |
| 92 | Rainbow Bible School INC | Recreation & Sports | $1.1M | $727K |
| 93 | Christian Service Center of Abilene INC | Human Services | $1.0M | $4.8M |
| 94 | Soulforce INC | Community Improvement & Capacity Building | $1.0M | $981K |
| 95 | Caraway Private Foundation | Philanthropy, Voluntarism & Grantmaking | $1.0M | $1.3M |
| 96 | Stick Horses and Capes | Human Services | $981K | $1.1M |
| 97 | Alliance for Innovation INC | Unclassified | $980K | $112K |
| 98 | J M Parker Foundation | Arts, Culture & Humanities | $973K | $26.9M |
| 99 | Hamby Water Supply Corporation | Unclassified | $933K | $1.1M |
| 100 | Abilene Woman S Club Foundation | Arts, Culture & Humanities | $924K | $1.0M |