| 1 | York Hospital | Health Care | $2.2B | $2.6B |
| 2 | Wellspan Medical Group | Health Care | $1.0B | $148.3M |
| 3 | Wellspan Health | Health Care | $846.0M | $697.2M |
| 4 | Chambersburg Hospital | Health Care | $630.7M | $561.5M |
| 5 | Gettysburg Hospital | Health Care | $475.8M | $555.0M |
| 6 | The Good Samaritan Hospital of Lebanon Pennsylvania | Health Care | $329.1M | $116.4M |
| 7 | Ephrata Community Hospital | Health Care | $321.3M | $143.3M |
| 8 | York College of Pennsylvania | Education | $269.7M | $577.8M |
| 9 | Waynesboro Hospital | Health Care | $141.6M | $161.4M |
| 10 | Wellspan Surgery and Rehabilitation Hospital | Health Care | $126.0M | $57.9M |
| 11 | Community Connections for Children INC | Human Services | $122.7M | $32.1M |
| 12 | York County Community Foundation | Philanthropy, Voluntarism & Grantmaking | $112.9M | $224.5M |
| 13 | Philhaven | Mental Health & Crisis Intervention | $85.8M | $42.4M |
| 14 | Spiritrust Lutheran | Human Services | $65.3M | $126.4M |
| 15 | Vna Home Health Services | Unclassified | $51.9M | $53.8M |
| 16 | Wellspan Health Care Services | Health Care | $41.9M | $77.1M |
| 17 | The Powder Mill Foundation | Unclassified | $38.6M | $146.7M |
| 18 | Family First Health Corporation | Health Care | $37.8M | $14.9M |
| 19 | Community Aid INC | Human Services | $34.3M | $44.7M |
| 20 | Arthur J Glatfelter Fire & Emergency Services Scholarship Fnd | Unclassified | $22.3M | $52.6M |
| 21 | Good Samaritan Physician Services | Health Care | $20.8M | $3.1M |
| 22 | Community Progress Council INC | Human Services | $19.1M | $4.1M |
| 23 | York Academy Regional Charter School | Education | $18.8M | $9.7M |
| 24 | Wellspan Properties INC | Housing & Shelter | $18.8M | $247.8M |
| 25 | YMCA | Human Services | $18.2M | $51.6M |
| 26 | York County Cerebral Palsy Home INC | Human Services | $17.8M | $14.5M |
| 27 | Association of Food and Drug Officials | Public & Societal Benefit | $17.4M | $4.6M |
| 28 | Bell Socialization Services INC | Unclassified | $16.7M | $9.6M |
| 29 | Shadowfax Corporation | Human Services | $15.7M | $16.3M |
| 30 | Typical Life Corporation | Human Services | $15.4M | $7.6M |
| 31 | Summit Health Foundation | Health Care | $14.4M | $72.4M |
| 32 | York Union Rescue Mission INC | Housing & Shelter | $14.0M | $9.1M |
| 33 | Lincoln Charter Academy | Education | $13.8M | $16.9M |
| 34 | Country Club of York | Recreation & Sports | $12.9M | $17.6M |
| 35 | Stewart Employee Benefit Trust | Unclassified | $12.3M | $1.7M |
| 36 | Arthur J Glatfelter Agency INC Employee Health & Welfare Fund | Unclassified | $11.2M | $74K |
| 37 | Young Womens Christian Association | Unclassified | $11.0M | $15.6M |
| 38 | Crispus Attucks Association of York Pennsylvania | Housing & Shelter | $10.8M | $29.7M |
| 39 | York County Agricultural Society | Recreation & Sports | $10.6M | $14.6M |
| 40 | York County Library System | Unclassified | $10.3M | $12.5M |
| 41 | York County Food Bank | Unclassified | $10.0M | $10.6M |
| 42 | Misericordia Convalescent Home | Unclassified | $8.9M | $14.2M |
| 43 | Jewish Community Centre of York Pennsylvania | Human Services | $8.2M | $12.1M |
| 44 | Jessica and Friends Community | Health Care | $7.9M | $6.6M |
| 45 | York Health Foundation | Health Care | $7.8M | $11.5M |
| 46 | Christian School Association of York INC | Religion-Related | $7.8M | $6.0M |
| 47 | The Arc of York County INC | Mental Health & Crisis Intervention | $7.6M | $3.0M |
| 48 | York County Society for the Prevention of Cruelty to Animals | Animal-Related | $7.4M | $9.9M |
| 49 | The Wagman Companies INC Employee Welfare Benefit Trust | Mutual & Membership Benefit | $7.2M | $1.9M |
| 50 | United Way of York County | Unclassified | $6.5M | $9.6M |
| 51 | Strand-capitol Performing Arts Center INC | Arts, Culture & Humanities | $6.4M | $15.0M |
| 52 | York County Economic Alliance | Community Improvement & Capacity Building | $5.4M | $4.5M |
| 53 | The Graham Foundation | Unclassified | $5.2M | $32.8M |
| 54 | York County Convention & Visitors Bureau INC | Unclassified | $5.2M | $6.2M |
| 55 | Lifes New Beginnings | Human Services | $4.6M | $3.8M |
| 56 | East Coast Volleyball INC | Recreation & Sports | $4.6M | $5.0M |
| 57 | Logos Academy | Education | $4.5M | $20.7M |
| 58 | York County History Center | Arts, Culture & Humanities | $4.5M | $41.4M |
| 59 | Margaret E Moul Foundation | Philanthropy, Voluntarism & Grantmaking | $4.4M | $14.1M |
| 60 | Ida Isma New Association | Community Improvement & Capacity Building | $4.2M | $4.6M |
| 61 | York County Bar Foundation | Crime & Legal-Related | $4.2M | $8.3M |
| 62 | Manufacturers Association of South Central Pa | Unclassified | $3.7M | $1.9M |
| 63 | Viking Athletic Assn. | Unclassified | $3.5M | $1.7M |
| 64 | Keystone Kidspace | Human Services | $3.5M | $5.8M |
| 65 | York Academy Foundation | Education | $3.5M | $43.4M |
| 66 | Shiloh American Legion Post 791 Home Association | Recreation & Sports | $3.4M | $1.1M |
| 67 | Susan P Byrnes Health Education Center INC | Health Care | $3.2M | $12.0M |
| 68 | Colonial House INC | Mental Health & Crisis Intervention | $3.1M | $3.7M |
| 69 | Partnership for Economic Development of York County INC | Community Improvement & Capacity Building | $3.1M | $1.4M |
| 70 | Point of View Foundation | Philanthropy, Voluntarism & Grantmaking | $3.0M | $3.9M |
| 71 | Hawk Gunning Club | Unclassified | $2.9M | $877K |
| 72 | Ephrata Community Health Foundation | Health Care | $2.8M | $5.9M |
| 73 | York Day Nursery INC | Education | $2.8M | $3.9M |
| 74 | Prince Athletic Association | Unclassified | $2.8M | $553K |
| 75 | Huber Foundation | Education | $2.7M | $26.6M |
| 76 | Martin Library Association | Education | $2.6M | $14.4M |
| 77 | Junior Achievement of South Central Pennsylvania | International, Foreign Affairs & National Security | $2.5M | $1.6M |
| 78 | Good Samaritan Health Services Foundation of Lebanon Pa | Health Care | $2.5M | $4.8M |
| 79 | Mantec INC | Community Improvement & Capacity Building | $2.5M | $2.7M |
| 80 | Crispus Attucks Charter School | Education | $2.4M | $1.4M |
| 81 | Cultural Alliance of York County | Arts, Culture & Humanities | $2.4M | $3.8M |
| 82 | American Legion Home Assoc INC Pleasurevill Post 799 | Unclassified | $2.1M | $28K |
| 83 | 12TH Ward Independent Democratic | Unclassified | $2.1M | $686K |
| 84 | Able-services INC | Employment | $2.1M | $2.1M |
| 85 | 13TH Ward Political Club | Unclassified | $2.0M | $687K |
| 86 | Victory Athletic Association of Spring Garden Township York County | Unclassified | $2.0M | $341K |
| 87 | Habitat for Humanity York INC | Housing & Shelter | $1.9M | $2.7M |
| 88 | Pennsylvania Immigration Resource Center | Crime & Legal-Related | $1.9M | $807K |
| 89 | Gti Hope | Education | $1.8M | $565K |
| 90 | Stillmeadow Child Care Ctr INC | Human Services | $1.8M | $979K |
| 91 | Bell Plus Development Corporation | Unclassified | $1.7M | $5.2M |
| 92 | Gettysburg Hospital Foundation | Unclassified | $1.7M | $25.1M |
| 93 | Susquehanna Regional Transportation Partnership INC | Public & Societal Benefit | $1.6M | $529 |
| 94 | International Brotherhood of Electrical Workers | Unclassified | $1.6M | $4.6M |
| 95 | Social Club of the Vigilant Fire Co | Unclassified | $1.6M | $420K |
| 96 | Mim Enck Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $1.5M | $8.3M |
| 97 | York County Bar Association | Unclassified | $1.4M | $1.7M |
| 98 | York Symphony Orchestra | Arts, Culture & Humanities | $1.3M | $8.2M |
| 99 | York Area Development Corporation | Housing & Shelter | $1.3M | $3.6M |
| 100 | Cloverfield-kingston House | Unclassified | $1.3M | $2.1M |