| 1 | Commonspirit Oregon | Health Care | $317.6M | $665.4M |
| 2 | Ford Family Foundation | Philanthropy, Voluntarism & Grantmaking | $206.9M | $1.1B |
| 3 | Adapt | Unclassified | $73.1M | $107.6M |
| 4 | Centennial Medical Group INC | Health Care | $66.0M | $38.8M |
| 5 | Douglas Forest Protective Association | Unclassified | $48.7M | $4.3M |
| 6 | Umpqua Community Health Center INC | Health Care | $45.5M | $59.5M |
| 7 | United Community Action Network | Human Services | $30.3M | $23.5M |
| 8 | Douglas Electric Cooperative INC | Unclassified | $25.9M | $89.2M |
| 9 | Umpqua Homes INC | Unclassified | $10.2M | $7.2M |
| 10 | Umpqua Community Development Corporation | Housing & Shelter | $9.5M | $40.7M |
| 11 | Douglas Residents Training Facility INC | Human Services | $7.4M | $10.5M |
| 12 | Community Cancer Foundation Community Cancer Center | Diseases, Disorders & Medical Disciplines | $5.7M | $14.6M |
| 13 | Umpqua College Foundation | Unclassified | $4.8M | $19.6M |
| 14 | Southern Oregon Regional Brokerage | Human Services | $4.5M | $4.6M |
| 15 | United Brotherhood of Carpenters & Joiners of America | Unclassified | $3.8M | $8.5M |
| 16 | Mercy Foundation INC | Unclassified | $3.6M | $6.8M |
| 17 | Family Development Center | Human Services | $3.4M | $4.1M |
| 18 | Roseburg Country Club | Unclassified | $3.4M | $4.6M |
| 19 | Sunrise Enterprises Foundation | Philanthropy, Voluntarism & Grantmaking | $3.3M | $1.6M |
| 20 | Phoenix School of Roseburg | Education | $3.3M | $3.2M |
| 21 | Sunrise Enterprises of Roseburg INC | Employment | $3.2M | $6.6M |
| 22 | Young Mens Christian Association of Douglas County | Human Services | $3.2M | $6.9M |
| 23 | Partnership for the Umpqua Rivers | Environment | $2.8M | $362K |
| 24 | Umpqua Valley Christian Schools | Education | $2.7M | $5.0M |
| 25 | Ccd Business Development Corporation | Unclassified | $2.7M | $9.9M |
| 26 | Phoenix School | Education | $2.7M | $1.6M |
| 27 | Umpqua Valley Defense Services INC | Unclassified | $2.6M | $1.5M |
| 28 | John & Jean Loosley Charitable Foundation Trust | Philanthropy, Voluntarism & Grantmaking | $2.6M | $1.6M |
| 29 | Roseburg Rotary Foundation | Education | $2.3M | $729K |
| 30 | Saving Grace INC | Animal-Related | $2.3M | $3.5M |
| 31 | Boys & Girls Club of the Umpqua Valley | Recreation & Sports | $2.0M | $4.7M |
| 32 | Douglas Public Health Network | Health Care | $1.9M | $973K |
| 33 | Peace at Home Advocacy Center | Human Services | $1.8M | $6.0M |
| 34 | Umpqua Valley Tennis Center INC | Recreation & Sports | $1.6M | $584K |
| 35 | Roseburg Resuce Mission INC | Housing & Shelter | $1.5M | $4.2M |
| 36 | Douglas County Childrens Center INC | Crime & Legal-Related | $1.5M | $170K |
| 37 | Hanna Family Perpetual Foundation INC | Unclassified | $1.3M | $1.9M |
| 38 | Safer Buildings | Public Safety, Disaster Preparedness & Relief | $1.2M | $529K |
| 39 | For the Love of Paws | Unclassified | $1.2M | $468K |
| 40 | Geneva Academy | Education | $1.1M | $551K |
| 41 | The Fish of Roseberg | Human Services | $1.1M | $1.2M |
| 42 | Absolutely Free INC | Religion-Related | $1.1M | $167K |
| 43 | Cobb Street Children Learning Center | Education | $970K | $635K |
| 44 | Aviva Qalicb | Community Improvement & Capacity Building | $901K | $20.2M |
| 45 | Briggs Loosley Foundation | Philanthropy, Voluntarism & Grantmaking | $811K | $1.8M |
| 46 | Family Faith and Relationship Advocates | Mental Health & Crisis Intervention | $741K | $123K |
| 47 | Umpqua Valley Gymnastics INC | Recreation & Sports | $704K | $122K |
| 48 | Caddock Foundation INC | Unclassified | $648K | $3K |
| 49 | Explore Engage Enjoy | Health Care | $624K | $66K |
| 50 | Fohs Foundation | Unclassified | $590K | $6.0M |
| 51 | Safe Haven Maternity Home | Unclassified | $580K | $427K |
| 52 | Greater Douglas United Way | Philanthropy, Voluntarism & Grantmaking | $565K | $525K |
| 53 | Heartwood Resources | Environment | $563K | $274K |
| 54 | Roseburg Dream Center INC | Human Services | $538K | $205K |
| 55 | Hope Services | Health Care | $528K | $1.0M |
| 56 | Altrusa International Foundation INC | Unclassified | $524K | $535K |
| 57 | Roseburg High School Foundation | Education | $510K | $734K |
| 58 | Umpqua Fishery Enhancement Derby | Environment | $488K | $578K |
| 59 | Thrive Umpqua | Public & Societal Benefit | $473K | $32K |
| 60 | Douglas County Association of Realtors | Unclassified | $449K | $647K |
| 61 | Umpqua Valley Arts Association | Arts, Culture & Humanities | $434K | $699K |
| 62 | Casa of Douglas County INC | Civil Rights, Social Action & Advocacy | $414K | $275K |
| 63 | Forest Bridges the O&c Forest Habitat Project INC | Environment | $395K | $268K |
| 64 | Umpqua Valley Disabilities Network | Human Services | $386K | $633K |
| 65 | Habitat for Humanity International INC | Unclassified | $383K | $976K |
| 66 | Chadwick Clubhouse | Mental Health & Crisis Intervention | $361K | $119K |
| 67 | Umpqua Actors Community Theatre INC | Arts, Culture & Humanities | $331K | $509K |
| 68 | Umpqua Valley Farm to School | Human Services | $327K | $143K |
| 69 | Douglas County Law Enforcement Association | Unclassified | $312K | $321K |
| 70 | Umpqua Valley Cal Ripken | Recreation & Sports | $307K | $132K |
| 71 | Douglas Timber Operators | Unclassified | $289K | $229K |
| 72 | Umpqua Valley Community Projects INC | Unclassified | $276K | $211K |
| 73 | Youth for Christ USA INC | Unclassified | $266K | $143K |
| 74 | Roseburg Senior Center | Youth Development | $245K | $1.0M |
| 75 | Douglas Multi-family Property Management | Housing & Shelter | $234K | $213K |
| 76 | Douglas County Library Foundation | Education | $227K | $3.9M |
| 77 | Benevolent & Protective Order of Elks of the USA | Unclassified | $222K | $370K |
| 78 | Helping Hands Payee Services INC | Human Services | $218K | $124K |
| 79 | Camp Millennium | Health Care | $207K | $317K |
| 80 | Roseburg Soccer Association | Recreation & Sports | $204K | $96K |
| 81 | Umpqua Economic Development Partnership | Community Improvement & Capacity Building | $196K | $52K |
| 82 | Umpqua Valley Winegrowers Association | Food, Agriculture & Nutrition | $194K | $119K |
| 83 | Payee by Jamie Fiduciary Services | Human Services | $193K | $10K |
| 84 | Music on the Half Shell | Arts, Culture & Humanities | $191K | $305K |
| 85 | Roseburg Chamber of Commerce | Unclassified | $179K | $259K |
| 86 | Source One Serenity | Human Services | $176K | $174K |
| 87 | Melrose Parent Teacher Action Network | Education | $176K | $244K |
| 88 | Thundering Water | Recreation & Sports | $175K | $58K |
| 89 | Forget Me Not Family Care Home | Human Services | $169K | $844K |
| 90 | Douglas County Cancer Services Committee | Unclassified | $164K | $38K |
| 91 | Oregon 4-H Foundation | Youth Development | $162K | $185K |
| 92 | Douglas County Livestock Assn. | Food, Agriculture & Nutrition | $155K | $57K |
| 93 | Real Hope Ministries INC | International, Foreign Affairs & National Security | $149K | $102K |
| 94 | Umpqua Symphony Association | Unclassified | $141K | $204K |
| 95 | Friends of Umpqua Valley Police Canine Programs | Crime & Legal-Related | $129K | $169K |
| 96 | Roseburg Playschool Cooperative INC | Unclassified | $128K | $31K |
| 97 | Umpqua Kennel Club | Unclassified | $128K | $77K |
| 98 | Rhs Cheer Booster Club | Recreation & Sports | $127K | $34K |
| 99 | Douglas Housing Alternatives INC | Housing & Shelter | $125K | $549K |
| 100 | International Association of Lions Clubs | Unclassified | $120K | $232K |