| 1 | Toledo Hospital | Health Care | $1.8B | $1.8B |
| 2 | Promedica Central Physicians LLC | Health Care | $338.7M | $129.4M |
| 3 | Hcr Manorcare INC | Health Care | $304.4M | $570.5M |
| 4 | Promedica Health System INC | Health Care | $273.7M | $910.3M |
| 5 | Promedica Foundation | Public & Societal Benefit | $256.2M | $392.8M |
| 6 | Mercy-memorial Hospital Corporation | Health Care | $196.5M | $76.8M |
| 7 | Emma L Bixby Medical Center | Health Care | $156.1M | $189.6M |
| 8 | Bay Park Community Hospital | Health Care | $135.4M | $56.0M |
| 9 | University of Toledo Physicians Clinical Facility INC | Unclassified | $115.5M | $73.7M |
| 10 | Defiance Hospital INC | Health Care | $103.9M | $46.6M |
| 11 | Memorial Hospital | Health Care | $94.8M | $55.5M |
| 12 | Promedica Continuum Services | Health Care | $87.6M | $14.9M |
| 13 | Toledo Museum of Art | Arts, Culture & Humanities | $79.3M | $403.8M |
| 14 | The University of Toledo Foundation | Education | $74.8M | $784.7M |
| 15 | 569 Directions Credit Union INC | Unclassified | $73.8M | $1.3B |
| 16 | Toledo Zoological Society | Animal-Related | $54.0M | $159.6M |
| 17 | Fostoria Hospital Association | Unclassified | $52.8M | $25.5M |
| 18 | Ohio Conference of Teamsters and Industry Health and Welfare Trust | Unclassified | $52.2M | $116.5M |
| 19 | Harbor | Mental Health & Crisis Intervention | $49.2M | $33.0M |
| 20 | Area Office on Aging of Northwestern Ohio INC | Human Services | $49.2M | $19.0M |
| 21 | Zepf Center | Unclassified | $41.7M | $23.9M |
| 22 | Toledo Community Foundation | Philanthropy, Voluntarism & Grantmaking | $40.9M | $246.9M |
| 23 | Lutheran Homes Society INC | Human Services | $35.9M | $41.7M |
| 24 | Goodwill Industries of Northwest Ohio INC | Employment | $34.1M | $26.8M |
| 25 | Promedica Physician Group INC | Health Care | $28.9M | $20.3M |
| 26 | John Henry Eldred Jr Foundation | Philanthropy, Voluntarism & Grantmaking | $27.0M | $48.8M |
| 27 | Unison Behavioral Health Group INC | Health Care | $26.4M | $12.3M |
| 28 | Promedica Multi Specialty Physicians LLC | Health Care | $25.1M | $3.7M |
| 29 | Choices Behavioral Health Care | Crime & Legal-Related | $24.8M | $3.2M |
| 30 | Owens Corning Foundation INC | Unclassified | $24.6M | $30.2M |
| 31 | Promedica Northwest Ohio Cardiology Consultants LLC | Health Care | $23.1M | $3.1M |
| 32 | Toledo Fire Fighters Local 92 Health & Welfare Plan | Unclassified | $22.0M | $14.1M |
| 33 | Teamster Oca Health & Welfare Fund | Unclassified | $21.9M | $6.9M |
| 34 | Mercy College of Ohio | Health Care | $20.3M | $36.8M |
| 35 | Promedica Monroe Physicians Pllc | Health Care | $19.1M | $5.5M |
| 36 | Maumee Valley Country Day School | Education | $18.6M | $10.8M |
| 37 | Inverness Club | Unclassified | $16.6M | $23.5M |
| 38 | Toledo Zoological Society Foundation | Animal-Related | $15.8M | $39.0M |
| 39 | Advocates for Basic Legal Equality | Unclassified | $15.0M | $17.4M |
| 40 | Memorial Professional Services Ltd | Health Care | $15.0M | $3.0M |
| 41 | Toledo Northwestern Ohio Foodbank INC | Food, Agriculture & Nutrition | $14.5M | $17.6M |
| 42 | Neighborhood Health Association of Toledo INC | Health Care | $14.1M | $26.7M |
| 43 | Toledo Alliance for the Performing Arts | Arts, Culture & Humanities | $12.6M | $28.5M |
| 44 | United Way of Greater Toledo | Philanthropy, Voluntarism & Grantmaking | $12.5M | $29.4M |
| 45 | Pathway INC | Education | $10.8M | $3.3M |
| 46 | Toledo Seagate Food Bank INC | Food, Agriculture & Nutrition | $10.7M | $7.8M |
| 47 | Toledo Clinic INC Employee Welfare Benefit Tr | Mutual & Membership Benefit | $10.5M | $4.6M |
| 48 | YWCA of Northwest Ohio | Human Services | $10.5M | $27.2M |
| 49 | Catholic Community Foundation - Ohio | Philanthropy, Voluntarism & Grantmaking | $10.3M | $18.5M |
| 50 | Promedica Childrens Specialists | Health Care | $9.7M | $995K |
| 51 | Ohio Council of Community Schools | Education | $9.7M | $8.8M |
| 52 | Public Broadcasting Foundation of Northwest Ohio | Arts, Culture & Humanities | $9.6M | $16.0M |
| 53 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $9.5M | $13.2M |
| 54 | West Side Montessori | Education | $9.5M | $14.7M |
| 55 | Legal Aid of Western Ohio INC | Crime & Legal-Related | $9.0M | $1.4M |
| 56 | Horizon Science Acadamey Toledo | Education | $8.9M | $16.7M |
| 57 | Neighborhood Properties INC | Mental Health & Crisis Intervention | $8.6M | $19.0M |
| 58 | Madison Avenue School of Arts | Education | $8.5M | $11.1M |
| 59 | Promedica Genito-urinary Surgeons LLC | Health Care | $8.1M | $935K |
| 60 | Franciscan Care Center | Human Services | $8.0M | $10.2M |
| 61 | Neighborhood Housing Services of Toledo INC | Unclassified | $8.0M | $16.3M |
| 62 | Toledo Christian Schools Incorporated | Unclassified | $8.0M | $5.6M |
| 63 | Moms House INC | Human Services | $7.9M | $9.5M |
| 64 | Lott Industries INC | Human Services | $7.1M | $9.8M |
| 65 | France Stone Foundation | Unclassified | $7.0M | $10.9M |
| 66 | Toledo Science Center | Arts, Culture & Humanities | $6.8M | $6.6M |
| 67 | Hospital Council of Northwest Ohio | Health Care | $6.6M | $6.0M |
| 68 | Historic South Initiative | Community Improvement & Capacity Building | $6.3M | $2.5M |
| 69 | Great Lakes Historical Society | Unclassified | $6.2M | $16.0M |
| 70 | Western Toledo Preparatory Academy | Education | $6.2M | $3.5M |
| 71 | Manahan | Human Services | $6.1M | $6.2M |
| 72 | Boys & Girls Club of Toledo | Unclassified | $6.0M | $23.6M |
| 73 | Horizon Science Academy-springfield | Education | $5.9M | $12.2M |
| 74 | Toledo Classic INC | Unclassified | $5.8M | $857K |
| 75 | L Hollingworth School for Talented and Gifted | Education | $5.7M | $2.9M |
| 76 | Empowered for Excellence Behavioral Health Club | Mental Health & Crisis Intervention | $5.5M | $5.4M |
| 77 | Toledo Country Club | Unclassified | $5.4M | $2.8M |
| 78 | Ability Center of Greater Toledo Supporting Organization | Diseases, Disorders & Medical Disciplines | $5.4M | $51.4M |
| 79 | Emmanuel Christian School | Education | $5.3M | $1.4M |
| 80 | Library Legacy Foundation of the Toledo-luce County Public Library | Education | $5.3M | $12.8M |
| 81 | Northwest Ohio Classical Academy | Education | $5.3M | $12.6M |
| 82 | Carolyn and Herbert Metzger Foundation | Philanthropy, Voluntarism & Grantmaking | $5.2M | $21.6M |
| 83 | Lucas County Economic Development Corporation | Community Improvement & Capacity Building | $5.1M | $88.1M |
| 84 | Ida Marie Dowling Trust XVII | Unclassified | $5.1M | $10.3M |
| 85 | International Brotherhood of Teamsters | Unclassified | $5.0M | $2.6M |
| 86 | Ebeid Family Foundation | Philanthropy, Voluntarism & Grantmaking | $5.0M | $25.6M |
| 87 | Kenmore Preparatory Academy | Education | $4.9M | $3.0M |
| 88 | Explorers Academy of Science and Technology | Education | $4.8M | $3.2M |
| 89 | Northwest Ohio Area Office on Aging Foundation | Human Services | $4.8M | $6.2M |
| 90 | Boy Scouts of America | Unclassified | $4.8M | $11.5M |
| 91 | Autism Model Community School | Education | $4.7M | $4.4M |
| 92 | Toledo Cultural Arts Center INC | Arts, Culture & Humanities | $4.7M | $9.1M |
| 93 | Toledo Preparatory and Fitness Academy | Education | $4.6M | $192K |
| 94 | Rfs Charitable Foundation | Public & Societal Benefit | $4.6M | $6.7M |
| 95 | Parksmart | Employment | $4.4M | $5.7M |
| 96 | Josina Lott Foundation | Human Services | $4.3M | $2.0M |
| 97 | Paramount Advantage | Unclassified | $4.2M | $500 |
| 98 | Adopt America Network | Human Services | $4.2M | $3.1M |
| 99 | Lutheran Social Services of Northwestern Ohio Foundation | Unclassified | $4.1M | $5.5M |
| 100 | Sunbridge Schools | Education | $4.1M | $3.5M |