| 1 | Knox Community Hospital | Health Care | $259.0M | $253.2M |
| 2 | Mount Vernon Nazarene University | Education | $75.6M | $101.0M |
| 3 | Knox County Foundation | Philanthropy, Voluntarism & Grantmaking | $33.7M | $116.2M |
| 4 | 544 C E S Credit Union INC | Unclassified | $12.1M | $223.7M |
| 5 | Knox County Land Reutilization Corporation | Community Improvement & Capacity Building | $8.7M | $11.3M |
| 6 | Ohio Eastern Star Health Care Center INC | Health Care | $7.9M | $817K |
| 7 | Veterans of Foreign Wars of the United States | Unclassified | $7.3M | $546K |
| 8 | Ohio Eastern Star Home | Health Care | $6.1M | $54.2M |
| 9 | Knox County Head Start INC | Education | $5.8M | $2.2M |
| 10 | The Ariel Foundation | Philanthropy, Voluntarism & Grantmaking | $4.7M | $38.6M |
| 11 | Cooper Park Development Company | Community Improvement & Capacity Building | $3.9M | $1.3M |
| 12 | Ohio Network for Innovation | Housing & Shelter | $3.6M | $6.4M |
| 13 | Firstborns North America | Philanthropy, Voluntarism & Grantmaking | $3.4M | $5.0M |
| 14 | Schnormeier Gardens Foundation | Arts, Culture & Humanities | $3.2M | $16.8M |
| 15 | Alcohol and Drug Freedom Center of Knox County | Mental Health & Crisis Intervention | $2.8M | $3.0M |
| 16 | Young Mens Christian Association of Mount Vernon Ohio | Human Services | $1.6M | $5.7M |
| 17 | Knox County Agricultural Society INC | Food, Agriculture & Nutrition | $1.5M | $1.3M |
| 18 | New Directions - the Domestic Abuse Shelter of Knox County | Unclassified | $1.5M | $2.2M |
| 19 | Colonial City Lodge 2555 Loyal Order of Moose | Unclassified | $1.5M | $1.7M |
| 20 | Area Development Foundation INC | Unclassified | $1.5M | $2.1M |
| 21 | Woodward Development Corporation | Arts, Culture & Humanities | $1.4M | $17.1M |
| 22 | United Way of Knox County Ohio INC | Unclassified | $1.4M | $1.6M |
| 23 | Interchurch Social Services of Knox County INC | Human Services | $1.4M | $2.9M |
| 24 | Knox New Hope Industries INC | Employment | $1.2M | $2.3M |
| 25 | Knox Development Partnership INC | Community Improvement & Capacity Building | $1.2M | $3.1M |
| 26 | Amvets | Unclassified | $785K | $473K |
| 27 | Benevolent & Protective Order of Elks of the USA | Unclassified | $723K | $711K |
| 28 | Knox Pregnancy Services Incorporated | Unclassified | $722K | $1.1M |
| 29 | Knox County Humane Society | Animal-Related | $692K | $2.1M |
| 30 | Ramser Arboretum | Environment | $670K | $9.9M |
| 31 | Habitat for Humanity International INC | Unclassified | $646K | $1.1M |
| 32 | Knox Community Hospital Foundation | Public Safety, Disaster Preparedness & Relief | $634K | $1.7M |
| 33 | Independence Industries | Housing & Shelter | $622K | $635K |
| 34 | Central Ohio Manufacturing Partnership | Employment | $615K | $128K |
| 35 | Jacket Boosters INC | Unclassified | $607K | $926K |
| 36 | Winter Sanctuary INC | Housing & Shelter | $403K | $843K |
| 37 | Knox Partnership for Arts and Culture INC | Arts, Culture & Humanities | $397K | $1.5M |
| 38 | Food for the Hungry | Food, Agriculture & Nutrition | $367K | $409K |
| 39 | Knox County Chamber of Commerce | Unclassified | $363K | $532K |
| 40 | Gary & Drenda Keesee Ministries INC | Religion-Related | $353K | $36K |
| 41 | Mount Vernon Arts Consortium INC | Unclassified | $338K | $125K |
| 42 | Owl Creek Conservancy | Environment | $329K | $3.9M |
| 43 | Knox County Convention and Visitors Bureau | Community Improvement & Capacity Building | $325K | $510K |
| 44 | Foundation Park Conservancy | Recreation & Sports | $294K | $908K |
| 45 | Mtvarts INC | Arts, Culture & Humanities | $284K | $292K |
| 46 | Lazarus Recovery Program INC | Mental Health & Crisis Intervention | $229K | $238K |
| 47 | Mount Vernon Music & Arts Festival INC | Arts, Culture & Humanities | $192K | $81K |
| 48 | Heritage Centre Association INC | Community Improvement & Capacity Building | $185K | $265K |
| 49 | Place 4 Grace | Human Services | $145K | $336K |
| 50 | Hopenow | Human Services | $135K | $90K |
| 51 | Science Play-space Initiative Spi INC | Education | $131K | $587K |
| 52 | Afrika Tikkun USA INC | International, Foreign Affairs & National Security | $125K | $1.2M |
| 53 | Touchpointe Marriage & Family Resources | Human Services | $105K | $83K |
| 54 | Knox County Memorial Building INC | Arts, Culture & Humanities | $98K | $77K |
| 55 | Mount Vernon Music Booster Club INC | Unclassified | $94K | $95K |
| 56 | Christian Star Academy INC | Education | $92K | $155K |
| 57 | Knox County Historical Society | Unclassified | $90K | $2.0M |
| 58 | Little League Baseball INC | Unclassified | $78K | $71K |
| 59 | Community Concert Association of Knox County | Arts, Culture & Humanities | $63K | $63K |
| 60 | American Steam Railroadpreservation Association INC | Arts, Culture & Humanities | $59K | $5K |
| 61 | Public Health Partnership of Knoxcounty | Health Care | $46K | $20K |
| 62 | Knox County Colt Football League Incorporated | Unclassified | $42K | $14K |
| 63 | North Fork Youth Athletic Association | Recreation & Sports | $35K | $1K |
| 64 | Escape Zone | Youth Development | $35K | $238K |
| 65 | Knox County Symphony Association | Unclassified | $35K | $113K |
| 66 | The Chiropractic Association of Ohio INC | Unclassified | $33K | $49K |
| 67 | Ohio Classical Conference | Arts, Culture & Humanities | $13K | $311K |
| 68 | Eastern Alliance for Production Katahdins | Food, Agriculture & Nutrition | $10K | $21K |
| 69 | Knox County Suicide Coalition | Mental Health & Crisis Intervention | $8K | $14K |
| 70 | Camp Cornish Foundation | Youth Development | $300 | $220K |
| 71 | Fraternal Order of Police | Unclassified | $0 | $0 |
| 72 | Vineyard Church of Knox County Incorporated | Religion-Related | $0 | $0 |
| 73 | B & L Ministries INC | Religion-Related | $0 | $0 |
| 74 | Knox Housing Services INC | Housing & Shelter | $0 | $0 |
| 75 | Shepherds House a Church of the Nazarene | Unclassified | $0 | $0 |
| 76 | Columbia Elementary Parent Teacherorganization INC | Education | $0 | $0 |
| 77 | National Exchange Club | Unclassified | $0 | $0 |
| 78 | Psi Iota XI Sorority | Unclassified | $0 | $0 |
| 79 | International Association of Lions Clubs | Unclassified | $0 | $0 |
| 80 | Apostolic Christian Church INC | Unclassified | $0 | $0 |
| 81 | Royal & Select Masons of Ohio | Unclassified | $0 | $0 |
| 82 | Royal Arch Masons of Ohio | Unclassified | $0 | $0 |
| 83 | Mystic Order of Veiled Prophets of Enchanted Realm | Unclassified | $0 | $0 |
| 84 | Mt Vernon Council No 847 Knights of Columbus | Mutual & Membership Benefit | $0 | $0 |
| 85 | Knox County Junior Miss Program INC | Youth Development | $0 | $0 |
| 86 | Ohio State University | Youth Development | $0 | $0 |
| 87 | Twin Oak Parent Teacher Organization | Education | $0 | $0 |
| 88 | Knox County Cattlemans Association | Animal-Related | $0 | $0 |
| 89 | Christians United in Christ Baptist Church | Unclassified | $0 | $0 |
| 90 | Kokosing Valley Community Tennis Assoication | Recreation & Sports | $0 | $0 |
| 91 | Grace Baptist | Unclassified | $0 | $0 |
| 92 | Ohio State University | Youth Development | $0 | $0 |
| 93 | Ohio State University | Youth Development | $0 | $0 |
| 94 | Mount Vernon Parking Co | Unclassified | $0 | $0 |
| 95 | Mulberry Street Methodist Church | Unclassified | $0 | $0 |
| 96 | Mt Vernon Foursquare Church | Unclassified | $0 | $0 |
| 97 | United Steelworkers | Unclassified | $0 | $0 |
| 98 | Free & Accepted Masons of Ohio | Unclassified | $0 | $0 |
| 99 | Mount Vernon Sda School | Unclassified | $0 | $0 |
| 100 | Mount Vernon Players | Arts, Culture & Humanities | $0 | $0 |