| 1 | Adena Health System | Health Care | $968.9M | $798.3M |
| 2 | Hopewell Health Centers INC | Unclassified | $86.5M | $54.0M |
| 3 | Adena Fayette Medical Center | Health Care | $73.7M | $18.8M |
| 4 | 0022 Homeland Credit Union INC | Unclassified | $34.6M | $583.0M |
| 5 | Frontier Community Services | Human Services | $21.5M | $62.8M |
| 6 | Ross County School Employees Ins Consortium Health & Welfare | Mutual & Membership Benefit | $17.0M | $2.8M |
| 7 | Goodwill Industries of South Central Ohio | Employment | $15.1M | $22.1M |
| 8 | Scioto Paint Valley Mental Health Center INC | Mental Health & Crisis Intervention | $14.1M | $7.9M |
| 9 | Ross County Water Company INC | Unclassified | $11.6M | $61.1M |
| 10 | Ross County Community Action Commission INC | Unclassified | $9.1M | $3.0M |
| 11 | Ross County Christian Academy INC | Education | $4.7M | $2.5M |
| 12 | Chillicothe-ross Community Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.3M | $14.6M |
| 13 | Chillicothe Cavalier Club | Education | $2.9M | $250K |
| 14 | Adena Health Foundation | Health Care | $2.6M | $10.0M |
| 15 | First Capital Enterprises INC | Employment | $2.4M | $4.3M |
| 16 | Ross County Committee for Elderly INC | Human Services | $2.3M | $468K |
| 17 | Ross County Agricultural Society | Food, Agriculture & Nutrition | $2.2M | $1.7M |
| 18 | Veterans of Foreign Wars of the United States Department of Ohio | Unclassified | $2.0M | $681K |
| 19 | Fraternal Order of Eagles | Unclassified | $1.9M | $637K |
| 20 | Young Mens Christian Association of Ross County | Human Services | $1.7M | $2.7M |
| 21 | Scioto Society INC | Arts, Culture & Humanities | $1.5M | $1.9M |
| 22 | Chillicothe Lodge No 1626 Loyal Order of Moose | Unclassified | $1.5M | $577K |
| 23 | Chillicothe Country Club Co | Unclassified | $1.2M | $959K |
| 24 | Ross County Junior Fair Salecommittee | Food, Agriculture & Nutrition | $1.1M | $26K |
| 25 | Ross County Humane Society INC | Animal-Related | $1.0M | $2.6M |
| 26 | United States Junior Chamber of Commerce | Unclassified | $995K | $1.3M |
| 27 | Synergy Family Foster Care INC | Human Services | $991K | $248K |
| 28 | American Legion | Unclassified | $952K | $760K |
| 29 | United Way of Ross County INC | Philanthropy, Voluntarism & Grantmaking | $935K | $1.9M |
| 30 | David Meade Massie Trust | Unclassified | $726K | $4.7M |
| 31 | Amvets | Unclassified | $636K | $220K |
| 32 | Ross County Historical Society INC | Arts, Culture & Humanities | $599K | $7.1M |
| 33 | The Garden Family Advocacy Center | Crime & Legal-Related | $590K | $868K |
| 34 | Southern Ohio Health Care Network INC | Health Care | $587K | $8.7M |
| 35 | Ross Chillicothe Convention and Visitors Bureau | Unclassified | $556K | $727K |
| 36 | Veterans in Transition INC | Human Services | $555K | $138K |
| 37 | The Academy for Kids Early Learning Center INC | Education | $532K | $56K |
| 38 | Joseph W Hoffman Post 757 of the American Legion Chillicothe Ohio | Public & Societal Benefit | $454K | $421K |
| 39 | Southern Ohio Career Academy | Education | $453K | $193K |
| 40 | Majestic Theatre INC | Recreation & Sports | $429K | $1.8M |
| 41 | Seeds of Hope INC | Housing & Shelter | $411K | $219K |
| 42 | Ross County Community Improvement Coporation | Unclassified | $410K | $2.0M |
| 43 | Elizabeths Hope Pregnancy Resources | Unclassified | $393K | $308K |
| 44 | Chillicothe Ross Chamber of Commerce | Unclassified | $372K | $427K |
| 45 | Benevolent & Protective Order of Elks of the USA | Unclassified | $357K | $417K |
| 46 | Peter J Blosser Scholarship Tr | Unclassified | $332K | $1.8M |
| 47 | Buck Fifty INC | Philanthropy, Voluntarism & Grantmaking | $306K | $107K |
| 48 | Charles L Franklin Trust | Unclassified | $296K | $3.4M |
| 49 | Adena Mansion and Gardens Society | Arts, Culture & Humanities | $279K | $104K |
| 50 | Downtown Chillicothe | Human Services | $258K | $92K |
| 51 | Whitehead-hinkle Tr | Education | $250K | $8.0M |
| 52 | Community Recreational Council of Chillicothe Ohio | Recreation & Sports | $249K | $47K |
| 53 | Habitat for Humanity International INC | Unclassified | $245K | $570K |
| 54 | United Steelworkers | Unclassified | $232K | $349K |
| 55 | Mighty Childrens Museum | Arts, Culture & Humanities | $230K | $315K |
| 56 | Hope Clinic of Ross County INC | Health Care | $226K | $201K |
| 57 | Open Your Heart INC | Unclassified | $225K | $1.2M |
| 58 | Good Samaritan Network of Ross County INC | Food, Agriculture & Nutrition | $193K | $395K |
| 59 | Economic Development Alliance of Southern Ohio | Community Improvement & Capacity Building | $188K | $223K |
| 60 | Foothold International INC | International, Foreign Affairs & National Security | $176K | $49K |
| 61 | Masonic Temple Association | Unclassified | $176K | $784K |
| 62 | International Brotherhood of Electrical Workers | Unclassified | $175K | $215K |
| 63 | Scioto Valley Youth League | Unclassified | $174K | $4K |
| 64 | Ross County Coalition Against Domestic Violence | Unclassified | $165K | $195K |
| 65 | Scioto Valley Youth League Softball | Recreation & Sports | $162K | $113K |
| 66 | Petland Charities | Animal-Related | $158K | $32K |
| 67 | Chillicothe Education Foundation | Unclassified | $156K | $2.2M |
| 68 | The Soul Phone Foundation | Science & Technology | $140K | $49K |
| 69 | Frontier Development Corporation INC | Housing & Shelter | $139K | $892K |
| 70 | Southeastern Athletic Boosters INC | Education | $137K | $124K |
| 71 | Shine on Chillicothe | Recreation & Sports | $137K | $109K |
| 72 | Ross-hocking Extension Camp Association INC | Community Improvement & Capacity Building | $135K | $155K |
| 73 | Unioto Athletic Boosters INC | Education | $130K | $79K |
| 74 | P U R R Fect Companions Cat Adoption Center INC | Animal-Related | $126K | $54K |
| 75 | American Federation of Government Employees | Unclassified | $126K | $79K |
| 76 | Zane Trace Athlethic Boosters Club | Unclassified | $122K | $38K |
| 77 | International Broadcasters Ideabank INC | Community Improvement & Capacity Building | $119K | $175K |
| 78 | Chillicothe Youth Soccer League INC | Unclassified | $111K | $37K |
| 79 | Chillicothe Civic Theatre INC | Unclassified | $106K | $649K |
| 80 | Hope Partnership Project | Mental Health & Crisis Intervention | $105K | $37K |
| 81 | Junior Civic League of Chillicothe Ohio INC | Unclassified | $104K | $25K |
| 82 | Root Cause Uganda | Philanthropy, Voluntarism & Grantmaking | $96K | $3K |
| 83 | Assistance House | Unclassified | $91K | $72K |
| 84 | Cats & Company | Housing & Shelter | $82K | $106K |
| 85 | Fraternal Order of Police | Unclassified | $80K | $53K |
| 86 | Huntsmen Xtra Point Club | Recreation & Sports | $80K | $14K |
| 87 | Rotary International | Unclassified | $80K | $68K |
| 88 | Pump House Art Gallery | Arts, Culture & Humanities | $78K | $153K |
| 89 | Ross County Conservation League INC | Environment | $77K | $135K |
| 90 | Build a Home INC | Housing & Shelter | $71K | $101K |
| 91 | Tristan Miller Music Scholarship | Youth Development | $68K | $100K |
| 92 | Rock for Tots INC | Human Services | $62K | $71K |
| 93 | Shelter in Place | Housing & Shelter | $61K | $1K |
| 94 | First Capital Ruck 22 | Public & Societal Benefit | $55K | $24K |
| 95 | Feast of the Flowering Moon INC | Arts, Culture & Humanities | $54K | $18K |
| 96 | Frends of Chillicothe Va Memorial Field | Philanthropy, Voluntarism & Grantmaking | $54K | $8K |
| 97 | Paper City Mentoring Project INC | Education | $54K | $62K |
| 98 | Southeastern Local Teachers Association | Unclassified | $53K | $12K |
| 99 | Chillicothe Rotary Foundation INC | Unclassified | $53K | $28K |
| 100 | Ross Christian Academy Foundation | Education | $53K | $68K |