| 1 | Area Agency on Aging | Human Services | $80.5M | $22.7M |
| 2 | Southeastern Ohio Regional Medical Center | Health Care | $75.6M | $119.9M |
| 3 | National Whitetail Deer Education | Arts, Culture & Humanities | $6.3M | $12.8M |
| 4 | Hospice of Guernsey INC | Human Services | $5.7M | $13.9M |
| 5 | Cambridge Area Young Mens Christian | Unclassified | $3.9M | $7.8M |
| 6 | Guernsey County Senior Citizens Center INC | Unclassified | $3.6M | $2.2M |
| 7 | 1143 Southeastern Ohio Credit Union INC | Unclassified | $3.5M | $57.4M |
| 8 | Guernsey County Community Development Corporation | Community Improvement & Capacity Building | $3.1M | $8.0M |
| 9 | United Assoc of Journeymen & Appren of Plumbing & Pipe Fitting Indst | Unclassified | $2.1M | $5.8M |
| 10 | Guernsey Couny Cancer Society INC | Human Services | $1.9M | $433K |
| 11 | Guernsey Residential INC | Unclassified | $1.7M | $860K |
| 12 | Ohio Mid-eastern Governments Assoc | Unclassified | $1.6M | $3.9M |
| 13 | Fraternal Order of Eagles | Unclassified | $1.5M | $457K |
| 14 | House of Samuel INC | Unclassified | $1.4M | $759K |
| 15 | Plumbers & Pipefitters | Unclassified | $904K | $1.6M |
| 16 | Benevolent & Protective Order of Elks of the USA | Unclassified | $866K | $548K |
| 17 | Pritchard-laughlin Center | Unclassified | $852K | $2.4M |
| 18 | Haven of Hope | Human Services | $841K | $1.3M |
| 19 | Forensic Diagnostic Center of District Nine INC | Mental Health & Crisis Intervention | $831K | $541K |
| 20 | Robert T Secrest Memorial VFW Post 2901 INC | Unclassified | $821K | $734K |
| 21 | Guernsey Health Choices INC | Mental Health & Crisis Intervention | $784K | $1.2M |
| 22 | Cambridge Lodge 631 Loyal Order of Moose | Unclassified | $692K | $915K |
| 23 | Cambridge Management Corporation | Housing & Shelter | $632K | $4.6M |
| 24 | Cambridge Guernsey County Visitors & Convention Bureau | Unclassified | $492K | $409K |
| 25 | Cassell Station Volunteer Fire Dept INC | Unclassified | $373K | $826K |
| 26 | Cambridge Area Chamber of Commerce | Unclassified | $297K | $252K |
| 27 | National Cambridge Collectors INC | Arts, Culture & Humanities | $288K | $1.9M |
| 28 | Cambridge-guernsey Community | Unclassified | $279K | $301K |
| 29 | Open Arms Pregnancy Center | Human Services | $273K | $694K |
| 30 | Community Industrial Association | Unclassified | $273K | $4.0M |
| 31 | Esthersam Foundation | Philanthropy, Voluntarism & Grantmaking | $250K | $453K |
| 32 | Ancient Accepted Scottish Rite of Free Masonry Nmj | Unclassified | $237K | $2.2M |
| 33 | Living Word Outdoor Drama INC | Religion-Related | $230K | $622K |
| 34 | Childrens Advocacy Center of Guernsey County | Crime & Legal-Related | $204K | $312K |
| 35 | Fraternal Order of Police | Unclassified | $179K | $177K |
| 36 | Cassell Station Volunteer Firemens Association INC | Public Safety, Disaster Preparedness & Relief | $178K | $1.0M |
| 37 | John and Nancy Abbott Fam Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $169K | $5.4M |
| 38 | Cambridge Bobcat Booster Club | Education | $152K | $133K |
| 39 | Cambridge Performing Arts Center | Unclassified | $142K | $291K |
| 40 | United Way of Guernsey and Noble Counties INC | Philanthropy, Voluntarism & Grantmaking | $134K | $330K |
| 41 | Pound Dog Partners of Guernsey County INC | Animal-Related | $120K | $158K |
| 42 | Guernsey County Feed My People INC | Unclassified | $112K | $227K |
| 43 | Cambridge Main Street Initiative INC | Religion-Related | $91K | $35K |
| 44 | Dickens Victorian Village of Cambridge INC | Arts, Culture & Humanities | $89K | $162K |
| 45 | Sportsmen for Conservation INC | Unclassified | $86K | $699K |
| 46 | Plumbers & Pipefitters Local 95 Educational Safety & Develop Tr | Unclassified | $84K | $334K |
| 47 | Guernsey Veterans Charity Fund INC | Philanthropy, Voluntarism & Grantmaking | $81K | $86K |
| 48 | Cambridge Rotary Foundation INC | Unclassified | $80K | $666K |
| 49 | Secret Santa of Guernsey County | Human Services | $77K | $177K |
| 50 | Cambridge Band Boosters | Education | $72K | $27K |
| 51 | Ohio Arts and Crafts Foundation | Unclassified | $61K | $79K |
| 52 | Samaritan Center | Housing & Shelter | $58K | $190K |
| 53 | Eastern Ohio Development Alliance | Community Improvement & Capacity Building | $54K | $40K |
| 54 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $48K | $9K |
| 55 | Ancient Accepted Scottish Rite of Free Masonry Nmj | Unclassified | $42K | $487K |
| 56 | Plumbers & Pipefitters Local Union No 95 Building Corporation | Unclassified | $36K | $487K |
| 57 | Eda Performing Elite INC | Arts, Culture & Humanities | $34K | $650 |
| 58 | Cambridge Kiwanis Foundation | Philanthropy, Voluntarism & Grantmaking | $31K | $1.1M |
| 59 | Southeastern Ohio Youth Shooting Sports Dba Hot Shots Trap Team | Youth Development | $29K | $55K |
| 60 | Southeast Diversified Industries INC | Unclassified | $18K | $165K |
| 61 | Living Free Events INC | Religion-Related | $17K | $6K |
| 62 | Wics INC | Human Services | $17K | $194K |
| 63 | Area Agency on Aging Region 9 Foundation | Human Services | $6K | $80K |
| 64 | Habitat for Humanity International INC | Unclassified | $5K | $694K |
| 65 | Christopher R Kuhn Memorial Scholarship Fund | Unclassified | $4K | $5K |
| 66 | Solid Rock Wesleyan Church | Unclassified | $0 | $0 |
| 67 | Three Rivers District Union of the United Methodist Church | Unclassified | $0 | $0 |
| 68 | Called to Freedom Fellowship | Religion-Related | $0 | $0 |
| 69 | Free & Accepted Masons of Ohio | Unclassified | $0 | $0 |
| 70 | Cambridge Education Association | Unclassified | $0 | $0 |
| 71 | Knights Templar of the United States of America | Unclassified | $0 | $0 |
| 72 | Royal & Select Masons of Ohio | Unclassified | $0 | $0 |
| 73 | Free & Accepted Masons of Ohio | Unclassified | $0 | $0 |
| 74 | Free & Accepted Masons of Ohio | Unclassified | $0 | $0 |
| 75 | Knights of Columbus | Mutual & Membership Benefit | $0 | $0 |
| 76 | Royal Arch Masons of Ohio | Unclassified | $0 | $0 |
| 77 | Jerry Dragosin Fraternal Order of Police Lodge 10 | Mutual & Membership Benefit | $0 | $0 |
| 78 | Fraternal Order of Eagles | Unclassified | $0 | $0 |
| 79 | Grace Pantry INC | Food, Agriculture & Nutrition | $0 | $0 |
| 80 | The Ohio State University | Youth Development | $0 | $0 |
| 81 | Veterans of Foreign Wars of the United States Department of Ohio | Unclassified | $0 | $0 |
| 82 | Guernsey County Firefighters Association | Public Safety, Disaster Preparedness & Relief | $0 | $0 |
| 83 | The Bridge Baptist Church | Unclassified | $0 | $0 |
| 84 | Guernsey County Veterans Council INC | Public & Societal Benefit | $0 | $0 |
| 85 | Cambridge Bible Church | Unclassified | $0 | $0 |
| 86 | Amvets | Unclassified | $0 | $0 |
| 87 | Trinity Baptist Church Cambridge | Unclassified | $0 | $0 |
| 88 | Church at Cambridge | Unclassified | $0 | $0 |
| 89 | Guernsey County Genealogical Society | Unclassified | $0 | $0 |
| 90 | Valley Grange 1580 | Unclassified | $0 | $0 |
| 91 | Midway Church of God | Unclassified | $0 | $0 |
| 92 | Guernsey County Right to Life Society | Unclassified | $0 | $0 |
| 93 | Abundant Life Pc G | Unclassified | $0 | $0 |
| 94 | Cambridge Amateur Radio Association INC | Arts, Culture & Humanities | $0 | $0 |
| 95 | Boden Northfield Chapel | Unclassified | $0 | $0 |
| 96 | The Cambridge Singers | Arts, Culture & Humanities | $0 | $0 |
| 97 | Fellowship Baptist Church | Unclassified | $0 | $0 |
| 98 | First Christian Church | Unclassified | $0 | $0 |
| 99 | Christian Methodist Episcopal Church | Unclassified | $0 | $0 |
| 100 | Cambridge Community Church | Unclassified | $0 | $0 |