| 1 | St. Catherine of Siena Medical Center | Health Care | $281.0M | $214.1M |
| 2 | Developmental Disabilities Institute INC | Human Services | $159.9M | $102.2M |
| 3 | Scope Education Services | Education | $44.9M | $27.0M |
| 4 | Guide Dog Foundation for the Blind INC | Unclassified | $40.2M | $63.5M |
| 5 | Banyan Tree Roots Foundation | Philanthropy, Voluntarism & Grantmaking | $18.0M | $10.0M |
| 6 | Americas Vetdogs the Veterans K9 Corps INC | Public & Societal Benefit | $10.9M | $4.6M |
| 7 | American Federation of Teachers | Unclassified | $1.1M | $943K |
| 8 | Guardians of Rescue INC | Animal-Related | $987K | $800K |
| 9 | Smithtown Volunteer Exempt Firemans Benevolent Association | Unclassified | $948K | $2.5M |
| 10 | Smithtown Performing Arts Counselinc | Arts, Culture & Humanities | $911K | $2.3M |
| 11 | Hildenbrand Family Foundation | Philanthropy, Voluntarism & Grantmaking | $840K | $5.3M |
| 12 | Environmental Centers of Setauket Smithtown INC | Environment | $751K | $997K |
| 13 | St. Catherine of Siena Medical Center Foundation | Unclassified | $722K | $2.3M |
| 14 | Suffolk County High School Hockey League INC | Recreation & Sports | $677K | $3K |
| 15 | New York City Firefighters Hockey Club INC | Unclassified | $668K | $330K |
| 16 | Association of Insurance and Reinsurance Run-off Companies INC | Community Improvement & Capacity Building | $622K | $606K |
| 17 | North Atlantic Alliance Association INC | Unclassified | $574K | $197K |
| 18 | American Federation of Teachers | Employment | $555K | $606K |
| 19 | Smithtown Historical Society | Arts, Culture & Humanities | $538K | $2.7M |
| 20 | Hauppauge Eagles INC | Recreation & Sports | $445K | $150K |
| 21 | New York State Rheumatology Society INC | Diseases, Disorders & Medical Disciplines | $432K | $346K |
| 22 | Friends of the Retired and Senior Volunteer Program of Suffolk Count | Human Services | $425K | $164K |
| 23 | Smithtown Teachers Association Benefit Fund | Employment | $371K | $174K |
| 24 | Booster Club of Smithtown | Recreation & Sports | $359K | $471K |
| 25 | International Association of Sheet Metal Air Rail & Transportation | Employment | $323K | $213K |
| 26 | Smithtown Cemetery Association INC | Unclassified | $298K | $934K |
| 27 | Human Potential Foundation | Unclassified | $263K | $8.7M |
| 28 | Physician Staff Fund at Saint Catherines | Mutual & Membership Benefit | $225K | $169K |
| 29 | Greater Smithtown Chamber of Commerce INC | Unclassified | $203K | $36K |
| 30 | Smithtown Fire Department INC | Public Safety, Disaster Preparedness & Relief | $200K | $1.4M |
| 31 | National Conference of Cpa | Unclassified | $196K | $247K |
| 32 | PTA New York Congress | Unclassified | $195K | $173K |
| 33 | Yorkie911 Rescue INC | Animal-Related | $180K | $314K |
| 34 | Straus Historical Society INC | Arts, Culture & Humanities | $162K | $530K |
| 35 | Benevolent & Protective Order of Elks of the USA | Unclassified | $149K | $504K |
| 36 | Nurse Practitioner Association of Long Island INC | Unclassified | $148K | $270K |
| 37 | American Academy of Pediatrics INC | Diseases, Disorders & Medical Disciplines | $146K | $249K |
| 38 | PTA New York Congress | Unclassified | $145K | $15K |
| 39 | Smithtown Township Lacrosse INC | Recreation & Sports | $141K | $47K |
| 40 | Manhattan Youth Baseball League INC | Recreation & Sports | $133K | $2K |
| 41 | Eight County Chapter Three of the American Academy of Pediatrics INC | Education | $111K | $477K |
| 42 | Strohm Foundation Ltd | Diseases, Disorders & Medical Disciplines | $108K | $48K |
| 43 | Notre Dame Club of Long Island INC | Education | $106K | $491K |
| 44 | Royal Order of Jesters | Unclassified | $105K | $46K |
| 45 | Suffolk County Electrical Contractors Association | Community Improvement & Capacity Building | $96K | $343K |
| 46 | Hopeforcleo INC | Human Services | $94K | $94K |
| 47 | Society for Lending Comforts to the Sick of the Township of Smithtown | Unclassified | $94K | $368K |
| 48 | Curvy Girls Foundation INC | Human Services | $90K | $494K |
| 49 | Rocky Point Lacrosse Booster Club INC | Education | $85K | $16K |
| 50 | Soulful Living for Addiction and Long Term Recovery INC | Mental Health & Crisis Intervention | $83K | $7K |
| 51 | PTA New York Congress | Unclassified | $81K | $43K |
| 52 | Smithtown Township Emergency Food Pantry | Food, Agriculture & Nutrition | $80K | $78K |
| 53 | Angel Guardians for the Elderly INC | Human Services | $75K | $484K |
| 54 | 4TH Precinct Fellowship INC | Community Improvement & Capacity Building | $70K | $40K |
| 55 | Hauppauge Eagles Booster Club INC | Recreation & Sports | $63K | $27K |
| 56 | Joseph P McKenna March Forth Foundation INC | Human Services | $61K | $10K |
| 57 | Decorative Furnishings Association INC | Unclassified | $59K | $10K |
| 58 | Suffolk County Tennis and Education Foundation INC | Recreation & Sports | $55K | $25K |
| 59 | Long Island Greenbelt Trail Conference INC | Environment | $48K | $256K |
| 60 | Quinn Family Foundation | Philanthropy, Voluntarism & Grantmaking | $40K | $400K |
| 61 | Zeldin Cares INC | Human Services | $33K | $29K |
| 62 | Smithtown Fire Chiefs Organization INC | Public Safety, Disaster Preparedness & Relief | $33K | $33K |
| 63 | The@mary F Smith Family Foundation | Philanthropy, Voluntarism & Grantmaking | $31K | $302K |
| 64 | Ivy League School Foundation INC | Education | $12K | $24K |
| 65 | Kimberly Coffey Foundation INC | Education | $9K | $316K |
| 66 | Michael McDermott Memorial Foundation INC | Education | $8K | $6K |
| 67 | Rising Tide Habilitation Services INC | Housing & Shelter | $5K | $4K |
| 68 | Joni E Gladowsky Breast Cancer Foundation Tr 07252002 | Medical Research | $3K | $20K |
| 69 | Dante Depinto Memorial Foundation | Philanthropy, Voluntarism & Grantmaking | $1 | $3 |
| 70 | John and Marion Lowenthal Foundation | Philanthropy, Voluntarism & Grantmaking | $1 | $3K |
| 71 | Astha USA INC | Civil Rights, Social Action & Advocacy | $1 | $1 |
| 72 | Sons of Italy in America | Unclassified | $0 | $0 |
| 73 | Smithtown Post 10870 Veterans of Foreign Wars of the United States | Public & Societal Benefit | $0 | $0 |
| 74 | Sons of Italy in America | Mutual & Membership Benefit | $0 | $0 |
| 75 | Maltese Family Fund INC | Education | $0 | $0 |
| 76 | Free & Accepted Masons of New York | Unclassified | $0 | $0 |
| 77 | St. Andrew Lutheran Church | Unclassified | $0 | $0 |
| 78 | First Presbyterian Church of Smithtown | Unclassified | $0 | $0 |
| 79 | Fair Harbor Property Owners Swim Association | Recreation & Sports | $0 | $0 |
| 80 | Experimental Aircraft Association Ch 594 Bay Shore Ny INC | Unclassified | $0 | $0 |
| 81 | World Messianic Fellowships INC Co | Unclassified | $0 | $0 |
| 82 | Church of St. Thomas of Canterbury | Unclassified | $0 | $0 |
| 83 | American Federations of Teachers | Community Improvement & Capacity Building | $0 | $0 |
| 84 | Federated Garden Clubs of New York State INC | Environment | $0 | $0 |
| 85 | PTA New York Congress | Unclassified | $0 | $0 |
| 86 | Long Island Blue Jays Jr Drum and Bugle Corps INC | Unclassified | $0 | $0 |
| 87 | The Suffolk County Senior Citizens Chorus INC | Unclassified | $0 | $0 |
| 88 | Smithtown Stitchers INC | Unclassified | $0 | $0 |
| 89 | Grace Church | Unclassified | $0 | $0 |
| 90 | Muttontown Horsemens Assoc INC | Animal-Related | $0 | $0 |
| 91 | PTA New York Congress | Unclassified | $0 | $0 |
| 92 | Nu Phi Zeta Chapter of Zeta Phi Beta Sorority | Unclassified | $0 | $0 |
| 93 | PTA New York Congress | Unclassified | $0 | $0 |
| 94 | Spiritual Assembly of the Bahais of Smithtown Town | Religion-Related | $0 | $0 |
| 95 | Youth Intervention Center INC | Housing & Shelter | $0 | $0 |
| 96 | PTA New York Congress | Education | $0 | $0 |
| 97 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 98 | New York Chongshin College and Theological Seminary | Education | $0 | $0 |
| 99 | PTA New York Congress | Unclassified | $0 | $0 |
| 100 | American Legion | Unclassified | $0 | $0 |