| 1 | Orleans Community Health | Health Care | $32.3M | $11.8M |
| 2 | Amgis Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.6M | $3.3M |
| 3 | Lee-whedon Memorial Library | Education | $1.5M | $1.3M |
| 4 | Medina Railroad Museum | Arts, Culture & Humanities | $1.4M | $1.5M |
| 5 | Shelridge Country Club INC | Unclassified | $1.2M | $450K |
| 6 | Veterans of Foreign Wars of the United States Department of New Yo | Unclassified | $1.1M | $99K |
| 7 | Junior Wilson Sportsmens Club INC | Unclassified | $1.0M | $377K |
| 8 | Orleans Community Health Foundation INC | Philanthropy, Voluntarism & Grantmaking | $549K | $1.3M |
| 9 | Medina United Methodist Church P Raising Kids Child Care Center | Human Services | $512K | $107K |
| 10 | Shelby Volunteer Fire Company INC | Public Safety, Disaster Preparedness & Relief | $413K | $2.3M |
| 11 | Sacred Heart Society | Recreation & Sports | $341K | $125K |
| 12 | W J Gallagher & Son Memorial Veterans Club INC | Unclassified | $272K | $22K |
| 13 | East Shelby Volunteer Fire Company INC | Unclassified | $253K | $2.3M |
| 14 | American Legion | Unclassified | $233K | $87K |
| 15 | Medina Area Association of Churches | Human Services | $178K | $272K |
| 16 | Richard Knights-sue Kaderli Memorial Fund | Human Services | $151K | $383K |
| 17 | Cmc Racing INC | Recreation & Sports | $137K | $180K |
| 18 | The Mustang Band Boosters of Medina Jr-sr High School | Unclassified | $130K | $43K |
| 19 | James P Clark Post American Legion INC | Unclassified | $101K | $13K |
| 20 | World Life Institute INC | Human Services | $80K | $286K |
| 21 | Medina Area Partnership | Community Improvement & Capacity Building | $76K | $81K |
| 22 | Knights of Columbus | Community Improvement & Capacity Building | $52K | $170K |
| 23 | Orleans Renaissance Group INC | Arts, Culture & Humanities | $47K | $108K |
| 24 | Lake Ontario Youth Athletic League INC | Youth Development | $45K | $34K |
| 25 | Orleans County Chamber of Commerce | Community Improvement & Capacity Building | $39K | $66K |
| 26 | Medina Scholarship Fund INC | Education | $7K | $51K |
| 27 | Holy Trinity Roman Catholic Church of Medina New York | Unclassified | $0 | $0 |
| 28 | Trinity Lutheran Church | Unclassified | $0 | $0 |
| 29 | Oak Orchard Assembly of God Church | Unclassified | $0 | $0 |
| 30 | Gateway to Heaven Pentecostal House of God Church | Religion-Related | $0 | $0 |
| 31 | Calvary Tabernacle Assembly of God | Unclassified | $0 | $0 |
| 32 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 33 | Imam Ali Institute INC | Religion-Related | $0 | $0 |
| 34 | Orleans County Christian School | Education | $0 | $0 |
| 35 | Animal Resue Service of Rochester | Animal-Related | $0 | $0 |
| 36 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 37 | Medina Conservation INC | Recreation & Sports | $0 | $0 |
| 38 | Community Christian Center | Religion-Related | $0 | $0 |
| 39 | First Baptist Church | Unclassified | $0 | $0 |
| 40 | Rotary International | Arts, Culture & Humanities | $0 | $0 |
| 41 | Delta Kappa Gamma Society International | Unclassified | $0 | $0 |
| 42 | Senior Citizens of Western Orleans INC | Human Services | $0 | $0 |
| 43 | Christian and Missionary Alliance Church | Unclassified | $0 | $0 |
| 44 | Medina Historical Society | Unclassified | $0 | $0 |
| 45 | Martin-linsin United Scholarship Awards | Education | $0 | $1 |
| 46 | Medina Sandstone Society INC | Arts, Culture & Humanities | $0 | $0 |
| 47 | Alabama Full Gospel Fellowship of Alabama State of New York | Unclassified | $0 | $0 |
| 48 | International Association of Lions Clubs | Unclassified | $0 | $0 |
| 49 | Butts Memorial Fund | Education | $0 | $0 |
| 50 | Catholic Daughters of the Americas | Unclassified | $0 | $0 |
| 51 | Faith Bible Baptist Church | Unclassified | $0 | $0 |
| 52 | Association of Twigs Medina Memorial Hospital | Health Care | $0 | $0 |
| 53 | Jeddo Community Chapel Church | Unclassified | $0 | $0 |
| 54 | Polish Roman Catholic Union of America 654 | Unclassified | $0 | $0 |
| 55 | American Federation of Teachers | Unclassified | $0 | $0 |
| 56 | Medina Ny Rotary Foundation | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 57 | Kitty Kove | Animal-Related | $0 | $0 |
| 58 | Medina Mustangs PTA | Education | $0 | $0 |
| 59 | Department of New York VFW Auxiliary | Public & Societal Benefit | $0 | $0 |
| 60 | Medina Memorial Garden | Environment | $0 | $0 |
| 61 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 62 | Friends of Medina Dog Park | Public & Societal Benefit | $0 | $0 |
| 63 | Operation Honor | Human Services | $0 | $0 |
| 64 | Home for the Holidays Foundation | Public & Societal Benefit | $0 | $0 |
| 65 | Mustang Sports Boosters | Recreation & Sports | $0 | $0 |
| 66 | Csea Unit 837-79500 Orleans Co County Unit | Unclassified | $0 | $0 |
| 67 | Growing Orchard Foundation | Human Services | $0 | $0 |
| 68 | Canalside Radio | Arts, Culture & Humanities | $0 | $0 |
| 69 | Guardian Angel Center INC | Education | $0 | $0 |
| 70 | Homeschool Harbor | Youth Development | $0 | $0 |