| 1 | Kalos Health INC | Health Care | $47.4M | $24.0M |
| 2 | Eastern Niagara Hospital INC | Health Care | $32.3M | $11.9M |
| 3 | Niagara Hospice INC | Human Services | $19.7M | $17.7M |
| 4 | Grigg Lewis Foundation INC | Philanthropy, Voluntarism & Grantmaking | $18.8M | $48.2M |
| 5 | Palliative Home Care of Niagara INC | Health Care | $8.3M | $6.9M |
| 6 | Kenan Center INC | Recreation & Sports | $7.5M | $13.7M |
| 7 | Hospice and Palliative Care Group INC | Health Care | $4.9M | $2.9M |
| 8 | Town & Country Club | Unclassified | $3.6M | $4.6M |
| 9 | Niagara Hospice Alliance INC | Human Services | $3.2M | $2.4M |
| 10 | Young Womens Christian Association of Niagra Frontier INC | Unclassified | $3.2M | $4.6M |
| 11 | Niagara Tobacco Asset Securitization Corp. | Public & Societal Benefit | $2.8M | $6.8M |
| 12 | Dale Association INC | Human Services | $2.4M | $1.8M |
| 13 | Nioga Library System | Education | $1.9M | $3.8M |
| 14 | Greater Lockport Development Corporation | Community Improvement & Capacity Building | $1.8M | $4.6M |
| 15 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $1.6M | $1.0M |
| 16 | Lockport Ice Arena & Sports Center INC | Recreation & Sports | $1.2M | $12.1M |
| 17 | Rapids Fire Co of Town of Lockport | Public Safety, Disaster Preparedness & Relief | $1.1M | $2.8M |
| 18 | Historic Palace INC | Arts, Culture & Humanities | $1.1M | $3.3M |
| 19 | South Lockport Voluinteer Fire Co INC | Human Services | $963K | $2.3M |
| 20 | Wrights Corners Fire Company INC | Public Safety, Disaster Preparedness & Relief | $896K | $3.4M |
| 21 | Mental Health Association in Niagara County INC | Unclassified | $800K | $76K |
| 22 | Benevolent & Protective Order of Elks of the USA | Mutual & Membership Benefit | $764K | $448K |
| 23 | Cambria Volunteer Fire Co | Public Safety, Disaster Preparedness & Relief | $637K | $1.7M |
| 24 | North Ridge Burial Association INC | Unclassified | $538K | $2.6M |
| 25 | Youth Mentoring Services of Niagara County INC | Unclassified | $517K | $423K |
| 26 | Niagara County Historical Society Incorporated | Unclassified | $513K | $2.1M |
| 27 | Lockport Community Television INC | Arts, Culture & Humanities | $503K | $1.7M |
| 28 | Odd Fellow and Rebekah Benefit Fund INC | Unclassified | $388K | $3.6M |
| 29 | Tioga Club of Lockport INC | Unclassified | $384K | $1.1M |
| 30 | Navy-marine Club INC | Unclassified | $355K | $568K |
| 31 | Lockport Cares INC | Education | $316K | $459K |
| 32 | Cold Spring Cemetery Association | Unclassified | $294K | $835K |
| 33 | Glenwood Cemetery Association | Mutual & Membership Benefit | $264K | $862K |
| 34 | Lockport Locks Heritage District Corporation | Community Improvement & Capacity Building | $241K | $1.6M |
| 35 | Haven of Hope Pregnancy Services INC | Unclassified | $237K | $531K |
| 36 | Opoverwatch INC | Religion-Related | $234K | $603K |
| 37 | Challenger Learning Center Oforleans Niagara and Erie Counties I | Education | $156K | $62K |
| 38 | Reid Fam Foundation | Education | $144K | $594K |
| 39 | North Forest Rod & Gun Club INC | Unclassified | $142K | $216K |
| 40 | Fuzzy Fawn Wildlife INC | Animal-Related | $141K | $1 |
| 41 | Diamonds in the Ruff Animal Rescue INC | Animal-Related | $131K | $71K |
| 42 | Lockport Robotics | Youth Development | $119K | $88K |
| 43 | Challenger Sports League INC | Recreation & Sports | $118K | $348K |
| 44 | Masons Mission Foundation INC | Human Services | $105K | $99K |
| 45 | Lockport Main Street INC | Community Improvement & Capacity Building | $103K | $47K |
| 46 | American Federation of Teachers | Unclassified | $101K | $111K |
| 47 | Civil Service Employees Association | Employment | $100K | $252K |
| 48 | Lock City Lodge No 617 Loyal Order of Moose | Unclassified | $98K | $601K |
| 49 | Western Ny Quarter Horse Club INC | Food, Agriculture & Nutrition | $96K | $75K |
| 50 | Lockport Soccer Club | Recreation & Sports | $94K | $41K |
| 51 | Devin Waring Foundation INC | Mental Health & Crisis Intervention | $89K | $27K |
| 52 | Lockport Little League Baseball Organization INC | Youth Development | $88K | $125K |
| 53 | Inkululeko | International, Foreign Affairs & National Security | $87K | $124K |
| 54 | Wahi Studio INC | Arts, Culture & Humanities | $80K | $17K |
| 55 | South Lockport Exempt Benevolent Association | Public Safety, Disaster Preparedness & Relief | $79K | $272K |
| 56 | Heart of Niagara Animal Rescue | Animal-Related | $76K | $6K |
| 57 | Niagara County Deputy Sheriffs Association | Unclassified | $72K | $263K |
| 58 | Dale Properties INC | Unclassified | $71K | $1.9M |
| 59 | Hickory Club Patrolmens Benevolent Association INC | Unclassified | $64K | $32K |
| 60 | Niagara Pride | Education | $59K | $79K |
| 61 | American Federation of Teachers | Unclassified | $56K | $15K |
| 62 | Western New York Physically Challenged Youth Sports Organ INC | Recreation & Sports | $55K | $189K |
| 63 | International Association of Lions Clubs | Unclassified | $55K | $425K |
| 64 | Glenwood Cemetery Foundation INC | Philanthropy, Voluntarism & Grantmaking | $51K | $125K |
| 65 | Niagara County Law Enforcement Foundation INC | Crime & Legal-Related | $46K | $17K |
| 66 | Kensington Lions Allstar High School Football Classic INC | Arts, Culture & Humanities | $45K | $28K |
| 67 | United Steelworkers | Unclassified | $44K | $144K |
| 68 | Royalton-hartland Agriculture Foundation INC | Education | $42K | $107K |
| 69 | Lakeview Animal Sanctuary INC | Unclassified | $41K | $3K |
| 70 | Niagara Alliance for Restorative Practices Incorporated | Crime & Legal-Related | $39K | $36K |
| 71 | An-jo Baseball Club of Lockport INC | Recreation & Sports | $34K | $24K |
| 72 | John R Lang Billselvis Charity Foundation INC | Human Services | $26K | $6K |
| 73 | Camp Happiness | Recreation & Sports | $25K | $69K |
| 74 | Lockport Public Arts Council INC | Arts, Culture & Humanities | $23K | $13K |
| 75 | Kenan Arts Council INC | Arts, Culture & Humanities | $19K | $34K |
| 76 | Mud Creek Central INC | Recreation & Sports | $15K | $44K |
| 77 | Love Like Ben Foundation INC | Recreation & Sports | $15K | $35K |
| 78 | Lockport High School Foundation | Education | $14K | $95K |
| 79 | Red Jacket Lodge No 646 F A&m | Philanthropy, Voluntarism & Grantmaking | $14K | $0 |
| 80 | International Association of Lions Clubs | Unclassified | $12K | $11K |
| 81 | Habitat for Humanity International INC | Unclassified | $6K | $479K |
| 82 | Lockport New Beginnings | Education | $566 | $28K |
| 83 | Collins Family Foundation INC | Education | $1 | $71K |
| 84 | Civil Service Employees Association | Unclassified | $0 | $0 |
| 85 | United States Bowling Congress INC | Recreation & Sports | $0 | $0 |
| 86 | Peacefull Pastures INC | Religion-Related | $0 | $0 |
| 87 | Lion of Judah Transformation Ministries | Religion-Related | $0 | $0 |
| 88 | American Legion | Public & Societal Benefit | $0 | $0 |
| 89 | The Masonic Temple Association of Lockport New York | Mutual & Membership Benefit | $0 | $0 |
| 90 | Wright Corners Cemetery Association | Mutual & Membership Benefit | $0 | $0 |
| 91 | 686 Club INC | Unclassified | $0 | $0 |
| 92 | All Saints Roman Catholic Parish | Unclassified | $0 | $0 |
| 93 | Emmanuel United Methodist Church | Unclassified | $0 | $0 |
| 94 | First Baptist Church of Lockport | Unclassified | $0 | $0 |
| 95 | Raymond Community Church | Religion-Related | $0 | $0 |
| 96 | Rapids Christian Chapel | Unclassified | $0 | $0 |
| 97 | Ancient Order of Hibernians in America | Unclassified | $0 | $0 |
| 98 | Niagara County 4-H Club Sponsors INC | Youth Development | $0 | $0 |
| 99 | Reformed Charismatic Congregation | Unclassified | $0 | $0 |
| 100 | Lake Ontario Trout & Salmon Association of Niagara INC | Unclassified | $0 | $0 |