| 1 | Washington University | Education | $9.2B | $20.5B |
| 2 | Bjc Health System | Health Care | $6.5B | $7.8B |
| 3 | Delta Dental of Missouri | Unclassified | $805.5M | $229.1M |
| 4 | Mid-america Transplant Services | Health Care | $125.6M | $133.5M |
| 5 | Bethesda Long Term Care INC | Health Care | $62.4M | $50.4M |
| 6 | Confluence Academy | Education | $57.1M | $64.6M |
| 7 | Bethesda Health Group Foundation of St. Louis INC | Health Care | $44.8M | $73.8M |
| 8 | American Association of Orthodontists | Unclassified | $38.1M | $34.6M |
| 9 | Area Resources for Community and Human Services | Human Services | $34.4M | $11.7M |
| 10 | American Optometric Association INC | Unclassified | $33.7M | $42.4M |
| 11 | Bethesda Senior Living INC | Housing & Shelter | $25.0M | $56.0M |
| 12 | Lutheran Family and Childrens Services Foundation INC | Philanthropy, Voluntarism & Grantmaking | $24.1M | $21.8M |
| 13 | Employee Benefit Trust for Retirees of Spire Missouri INC Covered by a | Unclassified | $18.6M | $173.2M |
| 14 | Lutheran Family and Childrens Services of Missouri | Unclassified | $18.0M | $13.3M |
| 15 | Biostl | Education | $17.8M | $19.1M |
| 16 | Ufcw Union Local No 88 Employers Health & Welfare Fund | Mutual & Membership Benefit | $17.1M | $21.5M |
| 17 | Regional Cultural & Performing Arts Development Commission | Arts, Culture & Humanities | $16.8M | $9.2M |
| 18 | Justine Petersen Housing and Reinvestment Corporation | Housing & Shelter | $14.4M | $86.3M |
| 19 | The Genome Partnership INC | Community Improvement & Capacity Building | $12.8M | $24.6M |
| 20 | The Opportunity Trust | Education | $12.6M | $4.0M |
| 21 | Biogenerator | Science & Technology | $9.0M | $14.0M |
| 22 | Child Day Care Association of Saint Louis | Human Services | $8.5M | $2.4M |
| 23 | Autonomous Case Management of St. Louis | Human Services | $8.3M | $7.8M |
| 24 | American Association of Orthodontists Foundation | Health Care | $8.0M | $39.7M |
| 25 | Big Brothers Big Sisters of Eastern Missouri | Unclassified | $7.9M | $22.9M |
| 26 | Spire Missouri INC Benefit Plan Trust Veba for Certain Non-union E | Unclassified | $7.6M | $44.7M |
| 27 | Bethesda Health Group INC | Human Services | $7.1M | $32.8M |
| 28 | Barnard Free Skin and Cancer Hospital | Health Care | $6.7M | $50.2M |
| 29 | Alabama Gas Corporation Retired Hourly Employee Benefit Plans Tr | Unclassified | $6.6M | $56.6M |
| 30 | Birthright Counseling St. Louis | Civil Rights, Social Action & Advocacy | $5.8M | $5.4M |
| 31 | Fund for Israels Tomorrow | International, Foreign Affairs & National Security | $5.2M | $2.2M |
| 32 | Southern Union Veba | Unclassified | $4.8M | $6.3M |
| 33 | Associated General Contractors of Missouri | Unclassified | $4.8M | $3.5M |
| 34 | Optometry Cares-the Aoa Foundation | Human Services | $4.7M | $4.3M |
| 35 | Christian Hospital Foundation | Health Care | $4.3M | $6.3M |
| 36 | Drury Family Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $4.0M | $11.1M |
| 37 | Bethesda Services INC | Health Care | $4.0M | $359K |
| 38 | Alabama Gas Corporation Retired Salaried Employee Benefit Plans Tr | International, Foreign Affairs & National Security | $3.9M | $34.9M |
| 39 | Stifel Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.7M | $1.7M |
| 40 | Berges Family Foundation | Public & Societal Benefit | $3.7M | $100.7M |
| 41 | Unite Here Local 74 Welfare and Dental Trust | Mutual & Membership Benefit | $3.6M | $1.1M |
| 42 | Impact Group Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $3.6M | $2.6M |
| 43 | Spire Foundation | Unclassified | $3.4M | $6.0M |
| 44 | Arthur R Thomas Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $3.4M | $3.3M |
| 45 | St. Louis Construction Training and Advancement Foundation | Unclassified | $3.2M | $6.1M |
| 46 | Delmar Divine Charitable Foundation | Community Improvement & Capacity Building | $3.1M | $21.2M |
| 47 | Chads Coalition for Mental Health | Mental Health & Crisis Intervention | $3.1M | $1.6M |
| 48 | Jca Charitable Foundation | Health Care | $3.0M | $7.6M |
| 49 | Missouri Organizing and Voter Engagement Action | Civil Rights, Social Action & Advocacy | $2.7M | $1.8M |
| 50 | Arthur and Helen Baer Charitable Foundation | Unclassified | $2.6M | $7.4M |
| 51 | Mechanical Contractors Association of Eastern Missouri INC | Community Improvement & Capacity Building | $2.5M | $5.7M |
| 52 | Erise Williams and Associates INC | Diseases, Disorders & Medical Disciplines | $2.4M | $2.1M |
| 53 | Kuhn Foundation | Philanthropy, Voluntarism & Grantmaking | $2.3M | $8.8M |
| 54 | St. Louis Voices Academy of Media Arts | Education | $2.1M | $321K |
| 55 | Empower Missouri | Human Services | $2.0M | $2.6M |
| 56 | Technical Assistance Corp. | Community Improvement & Capacity Building | $1.9M | $12.6M |
| 57 | Ypo INC | Unclassified | $1.6M | $987K |
| 58 | Unity Foundation Np | Science & Technology | $1.5M | $55K |
| 59 | Stl Youth Jobs | Youth Development | $1.5M | $561K |
| 60 | Missouri Budget Project | Human Services | $1.4M | $1.2M |
| 61 | Moshiri Family Foundation U-t-a Dated 1-7-2021 | Philanthropy, Voluntarism & Grantmaking | $1.4M | $624 |
| 62 | Booth Manor of St. Louis INC | Health Care | $1.0M | $3.1M |
| 63 | Missouri Bone & Joint Research Foundation | Mental Health & Crisis Intervention | $1000K | $4.1M |
| 64 | Anheuser-bush Brewery Conference Supplemental Unemployment Benf Fu | Unclassified | $998K | $12.2M |
| 65 | Unite Here | Unclassified | $996K | $477K |
| 66 | Bnei Baruch America INC | Religion-Related | $966K | $2.0M |
| 67 | Science Coach INC | Education | $941K | $445K |
| 68 | Centennial Housing Corp. | Housing & Shelter | $888K | $1.7M |
| 69 | St. Louis Christian Medical Center INC | Unclassified | $862K | $3.5M |
| 70 | St. Louis Aquarium at Union Station Foundation | Animal-Related | $786K | $2.0M |
| 71 | Hylton Point Apartments INC | Housing & Shelter | $765K | $1.8M |
| 72 | Inland Rivers Ports and Terminals INC | Unclassified | $737K | $549K |
| 73 | Dance Saint Louis | Arts, Culture & Humanities | $729K | $288K |
| 74 | American Optometric Student Association Incorporated | Unclassified | $692K | $1.4M |
| 75 | Retired Salaried Employee Group Insurance Plan Trust | International, Foreign Affairs & National Security | $688K | $14.1M |
| 76 | East Loop Community Improvement District | Community Improvement & Capacity Building | $683K | $560K |
| 77 | Mid West Gateway Rv Dealers Association | Unclassified | $657K | $528K |
| 78 | Law Library Association of St. Louis | Unclassified | $653K | $913K |
| 79 | Circus Harmony | Arts, Culture & Humanities | $631K | $706K |
| 80 | Oxbow Crossing and River Landing Public Improvement Company | Community Improvement & Capacity Building | $601K | $58K |
| 81 | John Allan Love Charitable Foundation | Unclassified | $600K | $3.2M |
| 82 | Community Builders Network of Metro St. Louis | Community Improvement & Capacity Building | $567K | $301K |
| 83 | Solea Water | Food, Agriculture & Nutrition | $537K | $329K |
| 84 | Veterans for Peace INC | Public & Societal Benefit | $523K | $269K |
| 85 | Gifted Resource Council | Education | $519K | $372K |
| 86 | Black Girls Do Stem | Education | $500K | $733K |
| 87 | American Board of Optometry | Education | $496K | $591K |
| 88 | Construction Forum | Human Services | $493K | $48K |
| 89 | Barnes Jewish Hospital Medical Staff Association | Unclassified | $470K | $511K |
| 90 | United Brotherhood of Carpenters & Joiners of America 1310 Carpet la | Unclassified | $462K | $291K |
| 91 | Communication Workers of America | Unclassified | $453K | $3.5M |
| 92 | Huhn Family Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $449K | $670K |
| 93 | Esco Technologies Foundation | Education | $427K | $510K |
| 94 | Philanthropy Missouri | Philanthropy, Voluntarism & Grantmaking | $390K | $425K |
| 95 | International Association of Bridge & Structural Iron Workers District | Unclassified | $389K | $672K |
| 96 | American Federation of Government Employees | Unclassified | $384K | $361K |
| 97 | St. Louis Housing and Service Corp. | Unclassified | $321K | $32K |
| 98 | St. Louis Altenheim | Unclassified | $318K | $4.6M |
| 99 | Ignite Theatre Company | Arts, Culture & Humanities | $317K | $5K |
| 100 | Agc of St. Louis Education Foundation | Education | $311K | $1.2M |