| 1 | Jefferson Foundation | Philanthropy, Voluntarism & Grantmaking | $101.9M | $196.6M |
| 2 | Upward Smiles INC | Health Care | $7.3M | $9.7M |
| 3 | Disability Resource Association INC | Human Services | $6.6M | $6.4M |
| 4 | Benevolent & Protective Order of Elks of the USA | Unclassified | $2.2M | $3.4M |
| 5 | Disability Resource in Homeservices INC | Diseases, Disorders & Medical Disciplines | $1.1M | $380K |
| 6 | Jefferson County Community Partnership INC | Community Improvement & Capacity Building | $828K | $1.2M |
| 7 | Assoc of Physician Assistants in Cardiothoracic Vascular Surgery in | Unclassified | $741K | $237K |
| 8 | American Legion | Unclassified | $736K | $777K |
| 9 | The Tarlow Family Foundation INC | Education | $382K | $2.9M |
| 10 | Veterans of Foreign Wars Dept of Missouri | Unclassified | $317K | $992K |
| 11 | Lancer Endowment at St. Pius X | Unclassified | $305K | $1.7M |
| 12 | Brendens Friday Back Pack | Human Services | $215K | $104K |
| 13 | Twin City Area Chamber of Commerce | Unclassified | $176K | $403K |
| 14 | Helping Hands and Horses INC | Health Care | $175K | $339K |
| 15 | Jeffco Shop with a Cop a Missouri Not for Profit Corporation | Youth Development | $167K | $138K |
| 16 | Missouri Justice League | Unclassified | $141K | $5K |
| 17 | Twelve Thirty Club Room INC | Unclassified | $125K | $30K |
| 18 | Is Today My Day Rescue | Animal-Related | $112K | $52K |
| 19 | Optimist International | Unclassified | $102K | $44K |
| 20 | Harvest Outreach Ministry INC | Religion-Related | $92K | $100 |
| 21 | Living Life on 2 Wheels INC | Unclassified | $77K | $140K |
| 22 | Cadet Thomas Michael Surdyke Memorial Foundation INC | Public & Societal Benefit | $71K | $59K |
| 23 | Ozark Food Pantry | Food, Agriculture & Nutrition | $58K | $581K |
| 24 | Mark and Debbie Benson Family Foundation | Unclassified | $47K | $23K |
| 25 | Hope Foundation - Bicm | International, Foreign Affairs & National Security | $45K | $90K |
| 26 | Festus-crystal City Chapter | Unclassified | $40K | $71K |
| 27 | Jefferson R-7 Parent Teacherorganization | Education | $37K | $52K |
| 28 | Andrew Habsieger Scholarship Foundation | Philanthropy, Voluntarism & Grantmaking | $21K | $10K |
| 29 | Storz Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $2K | $60K |
| 30 | Jolie Belle McFarland Foundation | Education | $302 | $12K |
| 31 | Jefferson County Water Authority | Unclassified | $0 | $0 |
| 32 | The Grace Center Church INC | Unclassified | $0 | $0 |
| 33 | Good News Community Church | Unclassified | $0 | $0 |
| 34 | Lakeview Christian Church | Unclassified | $0 | $0 |
| 35 | Ryan Sutton Ministries INC | Unclassified | $0 | $0 |
| 36 | Pbm Lambda Foundation | Education | $0 | $0 |
| 37 | Fraternal Order of Eagles | Unclassified | $0 | $0 |
| 38 | Jefferson County Art Guild | Arts, Culture & Humanities | $0 | $0 |
| 39 | Community Improvement Association of Crystal City | Community Improvement & Capacity Building | $0 | $0 |
| 40 | New Testament Baptist Church of Jefferson County | Unclassified | $0 | $0 |
| 41 | Bb5k INC | Mental Health & Crisis Intervention | $0 | $0 |
| 42 | Madalyn Robinson Foundation | Philanthropy, Voluntarism & Grantmaking | $0 | $0 |
| 43 | R7 Bluejay Foundation INC | Education | $0 | $0 |
| 44 | VFW Auxiliary Department of Missouri | Unclassified | $0 | $0 |
| 45 | St. Pius X Catholic High School | Unclassified | $0 | $0 |
| 46 | Brotherhood of Locomotive Engineers and Trainmen | Unclassified | $0 | $0 |
| 47 | Scarlets Dream Foundation | Public & Societal Benefit | $0 | $0 |
| 48 | Rural Youth Sports Engagement | Recreation & Sports | $0 | $0 |
| 49 | Heavens Closet INC | Human Services | $0 | $0 |
| 50 | De Soto Youth Basketball | Recreation & Sports | $0 | $0 |
| 51 | Ancient Free & Accepted Masons of Missouri | Unclassified | $0 | $0 |
| 52 | Our Lady Catholic Church | Unclassified | $0 | $0 |
| 53 | Amvets | Unclassified | $0 | $0 |
| 54 | Immanuel Lutheran Church | Unclassified | $0 | $0 |
| 55 | Calvery Christian Center | Unclassified | $0 | $0 |
| 56 | Selma Baptist Church | Unclassified | $0 | $0 |
| 57 | Knights of Columbus | Unclassified | $0 | $0 |
| 58 | Christus Building Corporation | Unclassified | $0 | $0 |
| 59 | 13TH District American Legion Department of Missouri | Public & Societal Benefit | $0 | $0 |
| 60 | Charter Baptist Church | Unclassified | $0 | $0 |
| 61 | River of Life Church | Unclassified | $0 | $0 |
| 62 | Faith Baptist Church of Festus Mo | Unclassified | $0 | $0 |
| 63 | First Christian Church | Unclassified | $0 | $0 |
| 64 | Twin City Church of Christ INC | Religion-Related | $0 | $0 |
| 65 | Lighthouse Baptist Church of Festus | Unclassified | $0 | $0 |
| 66 | Brotherhood of Locomotive Engineers and Trainmen | Unclassified | $0 | $0 |
| 67 | Mid East Missouri Contractors Association | Mutual & Membership Benefit | $0 | $0 |
| 68 | Fox Warrior Lacrosse Club | Recreation & Sports | $0 | $0 |
| 69 | The Gov Fletcher House Foundation INC | Arts, Culture & Humanities | $0 | $0 |
| 70 | Toastmasters International | Unclassified | $0 | $0 |
| 71 | Family Motor Coach Association | Unclassified | $0 | $0 |
| 72 | Living Hope Fellowship | Religion-Related | $0 | $0 |
| 73 | Festus Public Library Foundation INC | Education | $0 | $0 |
| 74 | David Goliath Foundation INC | Religion-Related | $0 | $0 |
| 75 | Douglass Alumni Association | Education | $0 | $0 |
| 76 | Radiant Life Pc G | Unclassified | $0 | $0 |
| 77 | Jefferson County Online Information Network | Public & Societal Benefit | $0 | $0 |
| 78 | Community Church of Jefferson County | Religion-Related | $0 | $0 |
| 79 | Twin City Youth Football Association | Recreation & Sports | $0 | $0 |
| 80 | Quad City Community Development Corp. | Human Services | $0 | $0 |
| 81 | Ozark Beagle Club | Recreation & Sports | $0 | $0 |
| 82 | International Association of Sheet Metal Air Rail & Transportation | Employment | $0 | $0 |
| 83 | Festus Presbyterian Methodist Cemetery Association | Mutual & Membership Benefit | $0 | $0 |
| 84 | Kiwanis International INC | Unclassified | $0 | $0 |
| 85 | United Daughters of the Confederacy | Unclassified | $0 | $0 |
| 86 | Access Housing Jefferson County | Housing & Shelter | $0 | $0 |
| 87 | Trinity Mt Carmel Church of Jefferson County | Religion-Related | $0 | $0 |
| 88 | Jefferson County Hunger Taskforce | Food, Agriculture & Nutrition | $0 | $0 |
| 89 | Graces Helping Hand INC Nfp | Human Services | $0 | $0 |
| 90 | Festus Football Booster Club | Recreation & Sports | $0 | $0 |
| 91 | Festus Tigers Volleyball Booster Club | Recreation & Sports | $0 | $0 |
| 92 | Little League Baseball INC | Unclassified | $0 | $0 |
| 93 | Amvets | Unclassified | $0 | $0 |
| 94 | Living Faith Ministries Church | Unclassified | $0 | $0 |
| 95 | Meadowbrook Christian Church | Religion-Related | $0 | $0 |
| 96 | The Festus Main Street Association | Arts, Culture & Humanities | $0 | $0 |
| 97 | Homeless Youth Initiative INC | Unclassified | $0 | $0 |
| 98 | Cultural Diversity Committee | Arts, Culture & Humanities | $0 | $0 |
| 99 | Festus Xc Booster Club | Education | $0 | $0 |
| 100 | Impact Church | Unclassified | $0 | $0 |