| 1 | UAW Retiree Medical Benefits Tr | Mutual & Membership Benefit | $96.1B | $62.9B |
| 2 | Blue Care Network of Michigan | Health Care | $16.9B | $2.4B |
| 3 | Henry Ford Health System | Health Care | $5.6B | $5.0B |
| 4 | Dte Energy Company Veba Tr | Mutual & Membership Benefit | $5.5B | $1.3B |
| 5 | Health Alliance Plan of Michigan | Health Care | $1.7B | $703.3M |
| 6 | International Union United Auto Aerospace & Agricultural Workers | Unclassified | $1.3B | $973.0M |
| 7 | Henry Ford Health St. John Hospital | Health Care | $1.1B | $532.9M |
| 8 | Henry Ford Health Providence Hospital | Health Care | $898.8M | $490.9M |
| 9 | Skillman Foundation | Education | $697.2M | $418.5M |
| 10 | Henry Ford Macomb Hospital Corporation | Health Care | $670.5M | $728.8M |
| 11 | Michigan Conference of Teamsters Welfare Fund | Unclassified | $665.0M | $716.9M |
| 12 | Barbara Ann Karmanos Cancer Hospital | Diseases, Disorders & Medical Disciplines | $574.7M | $237.1M |
| 13 | The Ralph C Wilson Jr Foundation | Philanthropy, Voluntarism & Grantmaking | $547.7M | $896.5M |
| 14 | Blue Cross Blue Shield of Michigan Bargaining Unit Internal Health | Mutual & Membership Benefit | $483.1M | $409.1M |
| 15 | Henry Ford Wyandotte Hospital Corporation | Health Care | $479.0M | $299.8M |
| 16 | Henry Ford Health Macomb Oakland Hospital | Health Care | $453.2M | $182.7M |
| 17 | Henry Ford Health Genesys Hospital | Health Care | $377.9M | $225.7M |
| 18 | The Detroit Institute of Arts | Arts, Culture & Humanities | $285.7M | $665.3M |
| 19 | University of Detroit Mercy | Education | $262.4M | $318.9M |
| 20 | Henry Ford Health Rochester Hospital | Health Care | $250.9M | $225.1M |
| 21 | Community Foundation for Southeast Michigan | Philanthropy, Voluntarism & Grantmaking | $246.2M | $1.2B |
| 22 | Gilbert Fam Foundation | Philanthropy, Voluntarism & Grantmaking | $211.8M | $53.1M |
| 23 | Wayne State University | Education | $177.2M | $596.3M |
| 24 | Ascension Michigan | Human Services | $166.3M | $31.4M |
| 25 | University Physician Group | Health Care | $155.2M | $88.7M |
| 26 | Samaritas | Human Services | $137.4M | $54.6M |
| 27 | Gleaners Community Food Bank of Southeastern Michigan | Food, Agriculture & Nutrition | $133.8M | $57.6M |
| 28 | Research Foundation for the City University of New York | Mutual & Membership Benefit | $130.7M | $260.5M |
| 29 | Wayne-metropolitan Community Action Agency | Community Improvement & Capacity Building | $116.3M | $65.2M |
| 30 | United Way for Southeastern Michigan | Public Safety, Disaster Preparedness & Relief | $114.9M | $88.9M |
| 31 | Barbara Ann Karmanos Cancer Institute | Medical Research | $112.4M | $250.7M |
| 32 | University Pediatricians | Health Care | $111.8M | $125.1M |
| 33 | Detroit Area Agency on Aging | Human Services | $105.2M | $45.5M |
| 34 | Childrens Hospital of Michigan Foundation | Health Care | $100.3M | $165.1M |
| 35 | College for Creative Studies | Education | $95.4M | $263.6M |
| 36 | Detroit Employment Solutions Corporation | Employment | $84.4M | $23.6M |
| 37 | Boy Scouts of America | Unclassified | $78.9M | $52.9M |
| 38 | Henry Ford Semi Medical Group | Health Care | $74.8M | $212.4M |
| 39 | Matrix Human Services | Unclassified | $63.3M | $29.9M |
| 40 | City of Detroit Post 2014 Non Safety Employee Retiree Health Car | Mutual & Membership Benefit | $59.9M | $47.1M |
| 41 | Comerica Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $57.7M | $87.1M |
| 42 | Detroit Symphony Orchestra Hall INC | Arts, Culture & Humanities | $55.6M | $117.0M |
| 43 | Detroit Athletic Club | Unclassified | $54.2M | $89.7M |
| 44 | Fund for Medical Research and Education | Unclassified | $49.5M | $45.4M |
| 45 | Dte Energy Foundation | Philanthropy, Voluntarism & Grantmaking | $46.5M | $129.1M |
| 46 | Martha P Mack Foundation | Philanthropy, Voluntarism & Grantmaking | $46.3M | $23.1M |
| 47 | Paul & Maxine Frohring Foundation INC | Unclassified | $45.7M | $108.8M |
| 48 | Goodwill Industries of Greater Detroit | Employment | $44.6M | $53.7M |
| 49 | Henry Ford Medical Group Genesys | Health Care | $43.8M | $49.6M |
| 50 | American Lightweight Materials Manufacturing Innovation Institute | Science & Technology | $43.3M | $59.6M |
| 51 | Detroit 90-90 | Education | $43.1M | $1.1M |
| 52 | Henry Ford Health System Foundation | Health Care | $40.0M | $394.3M |
| 53 | Michigan Humane Society | Animal-Related | $39.5M | $44.5M |
| 54 | Detroit Riverfront Conservancy INC | Recreation & Sports | $39.5M | $194.3M |
| 55 | St. John Providence | Health Care | $36.6M | $66.3M |
| 56 | Medical Center Emergency Services | Health Care | $36.5M | $6.7M |
| 57 | Focus Hope | Human Services | $35.1M | $11.9M |
| 58 | Southeastern Michigan Health Association | Unclassified | $33.8M | $9.9M |
| 59 | United Brotherhood of Carpenters & Joiners of America | Unclassified | $33.8M | $57.7M |
| 60 | Invest Detroit Foundation | Community Improvement & Capacity Building | $32.4M | $208.6M |
| 61 | McGregor Fund | Unclassified | $32.3M | $224.3M |
| 62 | Credit Unions Chartered in the State of Michigan | Unclassified | $30.6M | $498.1M |
| 63 | Rea Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $29.6M | $98.1M |
| 64 | Three Pillars Anew | Education | $29.0M | $9.2M |
| 65 | Henry Ford Physician Partners | Health Care | $28.4M | $7.0M |
| 66 | Blue Cross Blue Shield of Michigan Non-bargaining Unit Internal | Mutual & Membership Benefit | $26.0M | $30.2M |
| 67 | YMCA of Metropolitan Detroit | Human Services | $25.7M | $34.9M |
| 68 | Genesys Ambulatory Health Services INC | Health Care | $25.5M | $4.2M |
| 69 | Metropolitan Detroit Convention & Vistors Bureau | Unclassified | $23.4M | $30.2M |
| 70 | Foundation for Detroits Future | Community Improvement & Capacity Building | $22.5M | $47.9M |
| 71 | Detroit Golf Club | Unclassified | $22.4M | $25.7M |
| 72 | The Society of St. Vincent de Paul in the Archdiocese of Detroit | Human Services | $22.4M | $18.2M |
| 73 | Detroit Police Benefit and Protective Association | Unclassified | $22.1M | $27.6M |
| 74 | Downtown Detroit Partnership INC | Community Improvement & Capacity Building | $21.8M | $8.2M |
| 75 | New Paradigm for Education INC | Education | $21.8M | $11.1M |
| 76 | Neighborhood Service Organization | Unclassified | $21.3M | $30.1M |
| 77 | Marygrove Conservancy | Education | $21.0M | $134.3M |
| 78 | Terence & Jennifer Adderley Foundation | Philanthropy, Voluntarism & Grantmaking | $20.8M | $29.4M |
| 79 | Museum of African American History | Arts, Culture & Humanities | $20.8M | $31.7M |
| 80 | Harold P Bovenkerk Scholarship Tr | Philanthropy, Voluntarism & Grantmaking | $20.8M | $29.7M |
| 81 | Centers for Family Development Incorporated | Unclassified | $20.7M | $11.7M |
| 82 | Allied Media Projects INC | Arts, Culture & Humanities | $20.3M | $28.9M |
| 83 | Henry Ford Health River District Hospital | Health Care | $20.0M | $13.0M |
| 84 | Simpson Foundation | Unclassified | $19.8M | $25.1M |
| 85 | Development Centers INC | Health Care | $19.3M | $14.7M |
| 86 | International Brotherhood of Electrical Workers | Unclassified | $19.2M | $46.2M |
| 87 | Girl Scouts of Southeastern Michigan | Youth Development | $19.1M | $20.1M |
| 88 | Detroit Regional Chamber Foundation INC | Community Improvement & Capacity Building | $18.2M | $7.9M |
| 89 | The Wellness Plan | Health Care | $18.2M | $24.3M |
| 90 | Southwest Counseling Solutions INC | Mental Health & Crisis Intervention | $17.7M | $9.3M |
| 91 | Hudson-webber Foundation | Unclassified | $17.7M | $166.6M |
| 92 | Detroit Rescue Mission Ministries Genesis House I II III & Oasis | Mental Health & Crisis Intervention | $17.5M | $20.9M |
| 93 | Detroit Opera | Arts, Culture & Humanities | $17.1M | $49.6M |
| 94 | Childrens Center of Wayne County INC | Human Services | $16.9M | $17.2M |
| 95 | Matilda R Wilson Fund | Unclassified | $16.8M | $12.4M |
| 96 | New St. Paul Tabernacle Church of God in Christ Head Start Agency | Education | $16.7M | $4.4M |
| 97 | Pope Francis Center | Human Services | $16.2M | $44.0M |
| 98 | Uaw-ford Labor-management Committees Trust Fund | Employment | $16.1M | $5.3M |
| 99 | Community Health and Social Services Center INC | Health Care | $16.0M | $15.3M |
| 100 | Vera and Joseph Dresner Foundationinc | Philanthropy, Voluntarism & Grantmaking | $15.6M | $155.2M |