| 1 | National Center for Manufacturing Sciences | Community Improvement & Capacity Building | $568.5M | $323.8M |
| 2 | Iha Health Services Corporation | Health Care | $563.9M | $354.6M |
| 3 | Nsf International | Public Safety, Disaster Preparedness & Relief | $215.8M | $521.9M |
| 4 | National Advanced Mobility Consortium | Science & Technology | $190.8M | $33.3M |
| 5 | Merit Network INC | Public & Societal Benefit | $160.5M | $317.2M |
| 6 | Herrick Foundation | Unclassified | $153.9M | $179.1M |
| 7 | Cascade Hemophilia Consortium | Health Care | $138.1M | $100.8M |
| 8 | Organ Procurement Agency of Michigan | Unclassified | $121.6M | $78.9M |
| 9 | University Corporation for Advanced Internet Development | Science & Technology | $94.3M | $160.1M |
| 10 | Hospice of Michigan INC | Human Services | $90.3M | $114.8M |
| 11 | Credit Unions Chartered in the State of Michigan | Unclassified | $89.5M | $1.4B |
| 12 | Great Lakes Fishery Commission | Animal-Related | $75.6M | $89.6M |
| 13 | Ann Arbor Area Community Foundation | Philanthropy, Voluntarism & Grantmaking | $66.1M | $227.2M |
| 14 | The Hope Foundation | Diseases, Disorders & Medical Disciplines | $53.3M | $62.6M |
| 15 | Joint Board of Trustees IBEW | Unclassified | $52.1M | $10.5M |
| 16 | Eversight | Unclassified | $49.0M | $48.5M |
| 17 | Huron Valley Ambulance INC | Health Care | $37.0M | $30.6M |
| 18 | Orville D & Ruth a Merillat Foundation | Unclassified | $31.8M | $45.2M |
| 19 | Association for Advancing Automation | Unclassified | $31.4M | $42.1M |
| 20 | Planned Parenthood of Michigan | Health Care | $31.4M | $36.7M |
| 21 | Arbor Hospice INC | Human Services | $27.0M | $24.3M |
| 22 | Alumni Association of the University of Michigan | Education | $25.7M | $183.2M |
| 23 | Greenhills School | Education | $25.5M | $42.1M |
| 24 | State Alliance of Michigan Ymcas | Human Services | $23.9M | $16.2M |
| 25 | Food Gatherers | Unclassified | $23.7M | $18.3M |
| 26 | Ann Arbor District Library | Education | $22.7M | $51.3M |
| 27 | College for Healthcare Information Management Executives | Unclassified | $20.8M | $26.1M |
| 28 | Duffy Foundation | Unclassified | $19.3M | $7.4M |
| 29 | Great Lakes Colleges Association INC | Education | $18.5M | $19.4M |
| 30 | Health Level Seven International | Unclassified | $18.2M | $16.8M |
| 31 | Ann Arbor Housing Development Corporation | Housing & Shelter | $17.0M | $17.2M |
| 32 | Humane Society of Huron Valley | Animal-Related | $16.9M | $23.6M |
| 33 | Jewish Family Services of Washtenaw County INC | Unclassified | $16.1M | $8.0M |
| 34 | Packard Health INC | Health Care | $15.3M | $18.1M |
| 35 | Lifecare Ambulance | Health Care | $15.1M | $9.9M |
| 36 | College of Healthcare Information Management Executives Foundation | Unclassified | $14.8M | $12.0M |
| 37 | National Kidney Foundation INC | Diseases, Disorders & Medical Disciplines | $14.8M | $16.7M |
| 38 | Harry a & Margaret D Towsley Foundation | Unclassified | $14.7M | $48.9M |
| 39 | Timothy and Sheila Patton Family Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $14.2M | $28.6M |
| 40 | Martin Family Foundation | Philanthropy, Voluntarism & Grantmaking | $13.9M | $15.9M |
| 41 | Jackson Community Ambulance INC | Public Safety, Disaster Preparedness & Relief | $13.5M | $11.3M |
| 42 | Ann Arbor Spark | Unclassified | $12.9M | $19.0M |
| 43 | University Musical Society | Arts, Culture & Humanities | $12.4M | $48.4M |
| 44 | Avalon Nonprofit Housing Corp. | Housing & Shelter | $12.1M | $23.8M |
| 45 | J F Ervin Foundation | Unclassified | $11.9M | $4.6M |
| 46 | Barton Hills Country Club of Ann Arbor | Unclassified | $11.5M | $15.1M |
| 47 | American Society for Clinical Investigation INC | Unclassified | $11.2M | $15.5M |
| 48 | Recycle Ann Arbor | Environment | $10.9M | $9.9M |
| 49 | Montague Foundation | Philanthropy, Voluntarism & Grantmaking | $10.6M | $6.6M |
| 50 | Center for Healthcare Research & Transformation | Medical Research | $10.5M | $2.7M |
| 51 | Emerson School INC | Education | $9.8M | $13.1M |
| 52 | Adult Learning Systems-lower Michigan INC | Human Services | $9.4M | $6.2M |
| 53 | Washtenaw County Convention and Visitors Bureau INC | Unclassified | $9.1M | $7.7M |
| 54 | Ann Arbor YMCA | Unclassified | $8.9M | $29.3M |
| 55 | Cambridge Michigan Language Assessment LLC | Education | $8.5M | $11.5M |
| 56 | Legacy Land Conservancy | Environment | $7.9M | $12.4M |
| 57 | Supportive Care Services of Michigan INC | Philanthropy, Voluntarism & Grantmaking | $7.7M | $2.7M |
| 58 | Joak American Homes INC | Mental Health & Crisis Intervention | $7.7M | $2.1M |
| 59 | Rudolf Steiner School Association of Ann Arbor | Education | $7.7M | $11.5M |
| 60 | Monroe Community Ambulance | Public Safety, Disaster Preparedness & Relief | $7.3M | $3.7M |
| 61 | Legatus | Religion-Related | $7.3M | $11.4M |
| 62 | Habitat for Humanity International INC | Housing & Shelter | $7.3M | $10.9M |
| 63 | Huron River Watershed Council | Environment | $7.1M | $5.8M |
| 64 | Catholic Social Services of Washtenaw County | Unclassified | $7.0M | $7.2M |
| 65 | Michigan Pipe Trades Association | Unclassified | $7.0M | $3.4M |
| 66 | Travis Pointe Country Club | Recreation & Sports | $6.8M | $6.8M |
| 67 | Extracorporeal Life Support Organization | Health Care | $6.7M | $8.3M |
| 68 | Vaughan Foundation | Philanthropy, Voluntarism & Grantmaking | $6.7M | $18.7M |
| 69 | Laborers International Union of North America | Unclassified | $6.7M | $8.3M |
| 70 | Shelter Association of Washtenaw | Housing & Shelter | $6.6M | $7.3M |
| 71 | The J Ferrantino Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $6.6M | $11.3M |
| 72 | Burt Foundation | Philanthropy, Voluntarism & Grantmaking | $6.5M | $12.5M |
| 73 | Federation of State Conservation Voter Leagues INC | Environment | $6.1M | $3.5M |
| 74 | Kla Foundation | Philanthropy, Voluntarism & Grantmaking | $6.1M | $39.6M |
| 75 | Michigan Theater Foundation INC | Arts, Culture & Humanities | $5.8M | $14.2M |
| 76 | Wadhams Family Foundation | Philanthropy, Voluntarism & Grantmaking | $5.7M | $13.7M |
| 77 | Kiwanis Club of Ann Arbor | Community Improvement & Capacity Building | $5.7M | $5.9M |
| 78 | James a & Faith Knight Foundation | Philanthropy, Voluntarism & Grantmaking | $5.4M | $12.8M |
| 79 | International Brotherhood of Electrical Workers | Unclassified | $5.2M | $5.9M |
| 80 | Society for College & University Planning | Unclassified | $5.2M | $3.7M |
| 81 | Peace Neighborhood Center | Human Services | $5.0M | $8.4M |
| 82 | Dominos Pizza Partners Foundation INC | Unclassified | $4.9M | $21.5M |
| 83 | Ronald McDonald House Charities of Ann Arbor | Unclassified | $4.9M | $10.1M |
| 84 | Odva INC | Unclassified | $4.9M | $9.8M |
| 85 | Ann Arbor Hands on Museum | Arts, Culture & Humanities | $4.8M | $11.4M |
| 86 | Home of New Vision | Mental Health & Crisis Intervention | $4.7M | $1.6M |
| 87 | Association for Asian Studies INC | Unclassified | $4.7M | $14.1M |
| 88 | Hands Across the Water INC | Human Services | $4.7M | $1.8M |
| 89 | Iqm Research Institute | Science & Technology | $4.6M | $1.3M |
| 90 | Inter-cooperative Council at the University of Michigan | Unclassified | $4.5M | $10.0M |
| 91 | Child Care Network Washtenaw Regional 4C | Human Services | $4.3M | $1.1M |
| 92 | Emergent Health Partners | Health Care | $4.3M | $58.8M |
| 93 | Great Lakes Observing System Regional Association | Science & Technology | $4.2M | $694K |
| 94 | Non-profit Enterprise at Work INC | Community Improvement & Capacity Building | $4.2M | $2.4M |
| 95 | The Ark | Arts, Culture & Humanities | $4.0M | $4.8M |
| 96 | Daycroft | Education | $3.8M | $5.0M |
| 97 | Honey Creek Community School Corp. | Education | $3.8M | $3.6M |
| 98 | United Association of Journeymen & Apprentices of the Plumbing & Pipe | Unclassified | $3.7M | $6.4M |
| 99 | Sarc | Medical Research | $3.7M | $3.9M |
| 100 | Clonlara INC | Education | $3.6M | $3.5M |