| 1 | Memorial Hospital of South Bend | Health Care | $749.4M | $678.0M |
| 2 | Beacon Health System INC | Health Care | $562.4M | $1.3B |
| 3 | Everwise Credit Union | Unclassified | $330.0M | $5.3B |
| 4 | Community Foundation of St. Joseph County INC | Philanthropy, Voluntarism & Grantmaking | $240.6M | $327.4M |
| 5 | Beacon Medical Group INC | Health Care | $220.9M | $105.5M |
| 6 | Lesea Global Feed the Hungry INC | Philanthropy, Voluntarism & Grantmaking | $108.7M | $15.5M |
| 7 | Goodwill Industries of Michiana INC | Employment | $60.8M | $69.2M |
| 8 | Asante Foundation INC | Philanthropy, Voluntarism & Grantmaking | $47.9M | $156.7M |
| 9 | Logan Community Resources INC | Unclassified | $42.3M | $30.8M |
| 10 | South Bend Medical Foundation INC | Health Care | $36.3M | $45.3M |
| 11 | Real Services INC | Human Services | $30.3M | $15.0M |
| 12 | Career Academy of South Bend INC | Education | $30.0M | $57.3M |
| 13 | Beacon Health Foundation INC | Health Care | $29.7M | $50.5M |
| 14 | Food Bank of Northern Indiana | Food, Agriculture & Nutrition | $26.7M | $12.3M |
| 15 | Judd Leighton Foundation INC | Philanthropy, Voluntarism & Grantmaking | $21.2M | $149.6M |
| 16 | Womens Care Center INC | Health Care | $20.7M | $33.4M |
| 17 | International Brotherhood of Electrical Workers | Unclassified | $20.3M | $22.2M |
| 18 | Thomas F and Anita J Veldman Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $18.6M | $87.0M |
| 19 | St. Clair Darden Health System INC | Health Care | $16.9M | $9.2M |
| 20 | Boys and Girls Club of the Northern Indiana Corridor INC | Youth Development | $14.3M | $13.4M |
| 21 | Trinity Schools INC | Education | $14.0M | $7.1M |
| 22 | Southfiled Village INC | Human Services | $11.7M | $14.9M |
| 23 | First Source Foundation C/o 1ST Source Bank 100 N Michigan St. | Unclassified | $11.4M | $35.2M |
| 24 | Cultivate Culinary School and Catering INC | Employment | $10.9M | $12.3M |
| 25 | Stanley Clark School | Education | $9.6M | $18.8M |
| 26 | Drexel Funds | Education | $9.3M | $21.6M |
| 27 | Chamber of Commerce of St. Joseph County | Unclassified | $9.1M | $4.1M |
| 28 | Potawatomi Zoological Society INC | Animal-Related | $8.4M | $6.6M |
| 29 | Northern Indiana Workforce Board INC | Employment | $7.6M | $2.4M |
| 30 | Corvilla INC | Human Services | $7.1M | $7.3M |
| 31 | Shein Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $6.7M | $6.5M |
| 32 | Jon and Sonja Laidig Foundation INC | Philanthropy, Voluntarism & Grantmaking | $6.3M | $8.8M |
| 33 | Center for the Homeless INC | Unclassified | $6.2M | $18.7M |
| 34 | International Brotherhood of Teamsters | Unclassified | $5.9M | $2.9M |
| 35 | Enfocus INC | Community Improvement & Capacity Building | $5.8M | $2.0M |
| 36 | Youth Service Bureau of St. Joseph County INC | Human Services | $5.8M | $11.5M |
| 37 | Morris Park Country Club | Unclassified | $5.6M | $10.8M |
| 38 | YWCA North Central Indiana INC | Unclassified | $5.5M | $8.1M |
| 39 | Goodwill Leads | Education | $5.4M | $2.7M |
| 40 | St. Margarets House | Recreation & Sports | $5.2M | $6.6M |
| 41 | Venues Parks & Arts Foundation INC | Environment | $4.8M | $4.0M |
| 42 | South Bend Heritage Foundation INC | Community Improvement & Capacity Building | $4.7M | $23.2M |
| 43 | Borgess Health Alliance INC | Health Care | $4.5M | $52.7M |
| 44 | Michiana Public Broadcasting Corporation | Arts, Culture & Humanities | $4.5M | $6.4M |
| 45 | Boy Scouts of America | Unclassified | $4.3M | $9.2M |
| 46 | Foundations Child Care Center INC | Human Services | $3.9M | $2.5M |
| 47 | People of Praise INC | Unclassified | $3.9M | $19.9M |
| 48 | La Casa de Amistad INC | Unclassified | $3.8M | $5.8M |
| 49 | South Bend Youth Hockey INC | Recreation & Sports | $3.6M | $6.0M |
| 50 | United Way of St. Joseph County INC | Philanthropy, Voluntarism & Grantmaking | $3.4M | $14.4M |
| 51 | Wood Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.3M | $12.9M |
| 52 | Choicelight INC | Community Improvement & Capacity Building | $3.3M | $12.0M |
| 53 | Provident Ministries Ltd | Religion-Related | $3.2M | $1.5M |
| 54 | South Bend Hebrew Day School INC | Education | $3.2M | $1.6M |
| 55 | Pet Refuge INC | Animal-Related | $3.2M | $4.6M |
| 56 | Aids Ministries-aids Assist of North Indiana INC | Civil Rights, Social Action & Advocacy | $3.1M | $2.2M |
| 57 | Ronald McDonald House Charities of Indiana-michiana INC | Unclassified | $3.0M | $16.1M |
| 58 | United Association of Journeymen & Apprentices of the Plumbing & Pipe | Unclassified | $2.9M | $7.2M |
| 59 | Life Treatment Centers INC | Mental Health & Crisis Intervention | $2.8M | $3.8M |
| 60 | South Bend Symphony Orchestra Association INC | Arts, Culture & Humanities | $2.8M | $13.0M |
| 61 | Ohana Heritage Foundation INC | Health Care | $2.6M | $5.1M |
| 62 | Good Shepherd Montessori School INC | Education | $2.5M | $839K |
| 63 | 466 Works Community Development Corporation INC | Community Improvement & Capacity Building | $2.5M | $1.4M |
| 64 | Andean Health and Development INC | International, Foreign Affairs & National Security | $2.3M | $3.9M |
| 65 | Our Lady of the Road Incorporated | Housing & Shelter | $2.3M | $2.2M |
| 66 | Community Coordinated Child Care of St. Joseph County Incorporated 3517 | Human Services | $2.3M | $293K |
| 67 | Rescue Incorporated | Housing & Shelter | $2.3M | $4.1M |
| 68 | Northern in Historical Society | Arts, Culture & Humanities | $2.2M | $2.1M |
| 69 | Reins of Life INC | Unclassified | $2.1M | $4.3M |
| 70 | Laborers International Union of North America | Unclassified | $2.1M | $5.2M |
| 71 | Michiana Partnership INC | Community Improvement & Capacity Building | $2.1M | $1.2M |
| 72 | Edward F and Irma Hunter Foundation | Unclassified | $2.0M | $8.0M |
| 73 | Urban Enterprise Association of South Bend INC | Community Improvement & Capacity Building | $2.0M | $4.0M |
| 74 | Family & Childrens Center Couseling and Development Services INC | Unclassified | $1.9M | $1.5M |
| 75 | South Bend Empowerment Zone | Education | $1.9M | $288K |
| 76 | Jewish Federation of St. Joseph Valley INC | Unclassified | $1.8M | $13.7M |
| 77 | Transformation Ministries INC | Religion-Related | $1.8M | $8.0M |
| 78 | Indiana Dinosaur Museum | Arts, Culture & Humanities | $1.7M | $3.4M |
| 79 | Trustees of Purdue University | Unclassified | $1.7M | $1.6M |
| 80 | Ancient Accepted Scottish Rite of Free Masonry Nmj | Unclassified | $1.7M | $9.8M |
| 81 | Plym Foundation | Unclassified | $1.7M | $4.7M |
| 82 | South Bend Elkhart Regional Partnership Foundation | Community Improvement & Capacity Building | $1.7M | $2.8M |
| 83 | Studebaker National Museum INC | Arts, Culture & Humanities | $1.7M | $2.8M |
| 84 | Medical Education Foundation INC | Unclassified | $1.6M | $8.2M |
| 85 | Lasalle Park Homes INC | Housing & Shelter | $1.6M | $1.8M |
| 86 | Boy Scouts of America | Unclassified | $1.6M | $3.5M |
| 87 | Rhyme & Reason Ministry INC | Religion-Related | $1.4M | $777K |
| 88 | Business Development Corporation | Unclassified | $1.4M | $6.5M |
| 89 | South Bend Civic Theatre INC | Community Improvement & Capacity Building | $1.4M | $3.9M |
| 90 | South Bend & Vicinity Electrical | Employment | $1.4M | $1.8M |
| 91 | Cressy Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.3M | $2.1M |
| 92 | Saint Thomas More Academy INC | Education | $1.3M | $315K |
| 93 | Downtown South Bend INC | Unclassified | $1.3M | $516K |
| 94 | El Campito INC | Unclassified | $1.3M | $618K |
| 95 | Near Northwest Neighborhood INC | Unclassified | $1.2M | $3.3M |
| 96 | Garden Court INC | Housing & Shelter | $1.2M | $5.0M |
| 97 | Plumbers & Pipefitters Joint Apprenticeship Training Commitee | Unclassified | $1.1M | $1.7M |
| 98 | Creative Learning Child Development Ministry INC | Youth Development | $1.1M | $135K |
| 99 | Elkhart Health Fitness and Aquatics INC | Health Care | $1.1M | $52.8M |
| 100 | South Bend Museum of Art INC | Arts, Culture & Humanities | $1.1M | $3.1M |