| 1 | Savannah College of Art and Design INC | Education | $1.5B | $2.1B |
| 2 | Candler Hospital Incorporated | Health Care | $562.7M | $404.3M |
| 3 | Saint Josephs Hospital INC | Health Care | $354.5M | $209.6M |
| 4 | South University Member INC | Education | $305.4M | $156.3M |
| 5 | Itpeu Health & Welfare Fund | Unclassified | $83.3M | $86.5M |
| 6 | Georgia Stevedore Association- Inte Longshoremens Association | Unclassified | $82.4M | $67.2M |
| 7 | Landings Club INC | Recreation & Sports | $78.3M | $91.2M |
| 8 | Goodwill of the Coastal Empire INC | Employment | $76.2M | $52.6M |
| 9 | Georgia Stevedore Association Intl Longshoremens Assoc Welfare Fund | Unclassified | $50.9M | $61.9M |
| 10 | The Savannah Community Foundation INC | Unclassified | $46.2M | $103.6M |
| 11 | Southside Communities Fire Protection INC | Unclassified | $35.9M | $21.9M |
| 12 | Savannah Country Day School INC | Education | $34.0M | $73.5M |
| 13 | Young Mens Christian Association of Coastal Georgia INC | Human Services | $27.0M | $41.1M |
| 14 | Telfair Museum of Art INC | Arts, Culture & Humanities | $26.1M | $62.4M |
| 15 | Savannah Christian Preparatory School INC | Education | $25.5M | $33.7M |
| 16 | Curtis V Cooper Primary Health Care INC | Health Care | $25.1M | $18.7M |
| 17 | Savannah Area Chamber of Commerce | Unclassified | $24.4M | $21.1M |
| 18 | Americas Second Harvest of Coastal Georgia INC | Food, Agriculture & Nutrition | $23.6M | $48.7M |
| 19 | Skidaway Health and Living Services INC | Housing & Shelter | $20.5M | $102.0M |
| 20 | Riverview Health and Rehabiliation Center INC | Health Care | $19.1M | $16.4M |
| 21 | Hospice Savannah INC | Human Services | $17.4M | $23.1M |
| 22 | Union Mission INC | Housing & Shelter | $16.1M | $22.7M |
| 23 | Catholic Foundation of South Georgia INC | Unclassified | $14.2M | $63.3M |
| 24 | Economic Opportunity for Savannah Chatham County Area INC | Unclassified | $12.5M | $8.5M |
| 25 | St. Andrews on the Marsh INC | Unclassified | $11.6M | $11.2M |
| 26 | International Longshoremens Association | Unclassified | $11.3M | $24.3M |
| 27 | Community Childcare Food Supplement INC | Human Services | $11.1M | $2.1M |
| 28 | United Way of the Coastal Empire INC | Philanthropy, Voluntarism & Grantmaking | $10.1M | $25.5M |
| 29 | Sjc Home Health Services INC | Unclassified | $9.9M | $2.0M |
| 30 | Recovery Place Community Services INC | Housing & Shelter | $9.6M | $4.1M |
| 31 | Savannah Yacht Club INC | Unclassified | $9.5M | $15.0M |
| 32 | Bethesda Union Society of Savannah | Human Services | $9.3M | $36.6M |
| 33 | Ralston College INC | Education | $9.3M | $16.6M |
| 34 | The Savannah Classical Academy a Challenge Foundation Academy | Education | $8.8M | $8.2M |
| 35 | Savannah Golf Club INC 1661 E President St. | Unclassified | $8.5M | $20.0M |
| 36 | Oglethorpe Charter School INC | Education | $8.0M | $8.9M |
| 37 | Colonial Foundation INC | Unclassified | $7.9M | $13.8M |
| 38 | Working Forest Initiative | Community Improvement & Capacity Building | $7.6M | $1.5M |
| 39 | Georgia Historical Society | Unclassified | $7.0M | $35.6M |
| 40 | Workmens Circle Credit Union | Public & Societal Benefit | $6.7M | $125.9M |
| 41 | National Museum of the Mighty Eighth Air Force INC | Philanthropy, Voluntarism & Grantmaking | $6.7M | $9.5M |
| 42 | Parents and Friends of Hancock INC | Education | $6.7M | $8.5M |
| 43 | Savannah State College Foundation INC | Unclassified | $6.6M | $68.0M |
| 44 | Senior Citizens INC | Human Services | $5.9M | $8.6M |
| 45 | Small Business Assistance Corp. | Community Improvement & Capacity Building | $5.9M | $22.3M |
| 46 | The Littlejohn Family Foundation | Philanthropy, Voluntarism & Grantmaking | $5.8M | $10.7M |
| 47 | Goodwill Industries of the Coastal Empire INC | Employment | $5.6M | $7.2M |
| 48 | Jewish Educational Alliance of Savannah Georgia INC | Religion-Related | $5.2M | $10.7M |
| 49 | Candler Foundation INC | Health Care | $5.2M | $12.8M |
| 50 | Community Housing Services Agency INC | Housing & Shelter | $5.0M | $19.6M |
| 51 | Hospice Savannah Foundation INC | Health Care | $4.9M | $14.3M |
| 52 | Office and Proffessional Employees International Union | Unclassified | $4.8M | $7.4M |
| 53 | Susie King Taylor Community School INC | Education | $4.5M | $1.4M |
| 54 | Protestant Episcopal Church in the Diocese of Georgia INC | Religion-Related | $4.0M | $15.2M |
| 55 | Coastal Heritage Society INC | Unclassified | $4.0M | $4.5M |
| 56 | Ronald McDonald House Charities of the Coastal Empire INC | Unclassified | $4.0M | $6.4M |
| 57 | J C Lewis Foundation INC | Unclassified | $3.9M | $38.5M |
| 58 | Dh Rowe Foundation | Philanthropy, Voluntarism & Grantmaking | $3.8M | $2.6M |
| 59 | Mighty Eighth Foundation INC | Arts, Culture & Humanities | $3.7M | $2.6M |
| 60 | Savannah Music Festival INC | Arts, Culture & Humanities | $3.7M | $2.9M |
| 61 | Hsgs Foundation INC | Animal-Related | $3.6M | $2.8M |
| 62 | Georgia Infirmary INC | Unclassified | $3.6M | $6.0M |
| 63 | Ships of the Sea Maritime Museum INC | Unclassified | $3.3M | $20.4M |
| 64 | Drr Family Foundation | Unclassified | $3.3M | $7.5M |
| 65 | Courtney Knight Gaines Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.3M | $9.7M |
| 66 | The Habersham School INC | Education | $3.1M | $1.1M |
| 67 | Royce Learning Center | Unclassified | $3.1M | $1.9M |
| 68 | Coastal Empire Habitat for Humanity | Unclassified | $3.0M | $3.9M |
| 69 | Chatham Club INC | Unclassified | $3.0M | $5.0M |
| 70 | Chatham-savannah Authority for the Homeless | Human Services | $2.9M | $2.7M |
| 71 | Living Vine INC | Health Care | $2.8M | $1.9M |
| 72 | Employ Ability INC | Human Services | $2.7M | $1.6M |
| 73 | Georgia Infirmary Non Profit Housing Corporation | Housing & Shelter | $2.7M | $2.2M |
| 74 | Oglethorpe Club | Recreation & Sports | $2.7M | $1.6M |
| 75 | Jepson Scholars Foundation | Education | $2.6M | $11.0M |
| 76 | Coastal Empire Montessori Community Organization INC | Education | $2.6M | $2.4M |
| 77 | Philip & Shirley Solomons Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.6M | $10.0M |
| 78 | Boy Scouts of America | Unclassified | $2.5M | $8.3M |
| 79 | The Humane Society for Greater Savannah INC | Animal-Related | $2.4M | $2.4M |
| 80 | Day Family Foundation Tr Dated July 20 2021 | Philanthropy, Voluntarism & Grantmaking | $2.4M | $5.3M |
| 81 | Chsa Development INC | Unclassified | $2.3M | $5.5M |
| 82 | Memorial Day School INC | Education | $2.2M | $2.1M |
| 83 | Progressive Abilities Support Services INC | Education | $2.2M | $134K |
| 84 | International Longshoremens Association | Employment | $2.2M | $2.6M |
| 85 | Sapelo Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.2M | $35.5M |
| 86 | Scps Foundation INC | Education | $2.1M | $8.8M |
| 87 | The Chatman Foundation | Unclassified | $2.1M | $5.8M |
| 88 | Catalyst Development Corporation | Housing & Shelter | $2.1M | $2.7M |
| 89 | Savannah Jewish Council INC | Religion-Related | $2.1M | $12.8M |
| 90 | Safe Shelter Center for Domestic Violence Services INC | Human Services | $2.0M | $1.7M |
| 91 | Savannah Community Builders INC | Housing & Shelter | $2.0M | $8.0M |
| 92 | Savannah Philharmonic Corporation | Arts, Culture & Humanities | $2.0M | $733K |
| 93 | St. Josephs Foundation of Savannah INC | Unclassified | $2.0M | $3.5M |
| 94 | Deep Center Incorporated | Arts, Culture & Humanities | $2.0M | $2.7M |
| 95 | Historic Savannah Foundation Incorporated | Unclassified | $1.9M | $12.1M |
| 96 | Greenbriar Childrens Center INC | Human Services | $1.9M | $1.9M |
| 97 | Brightside Child and Family Advocacy INC | Civil Rights, Social Action & Advocacy | $1.9M | $831K |
| 98 | Rambam Day School INC | Education | $1.8M | $3.6M |
| 99 | Renegade Paws Rescue | Animal-Related | $1.8M | $1.1M |
| 100 | Savannah Classical Academy Foundation INC | Education | $1.8M | $7.8M |