| 1 | The Medical Center INC | Health Care | $593.8M | $285.1M |
| 2 | Hughston Hospital INC | Health Care | $157.3M | $77.8M |
| 3 | Community Foundation of the Chattahoochee Valley INC | Philanthropy, Voluntarism & Grantmaking | $86.0M | $349.0M |
| 4 | Synovus Financial Corp Medical & | Unclassified | $60.2M | $8.4M |
| 5 | Goodwill Industries of the Southern Rivers INC | Employment | $58.2M | $77.0M |
| 6 | Columbus Ambulatory Healthcare Services INC | Unclassified | $55.4M | $19.7M |
| 7 | Soma Foundation INC | Philanthropy, Voluntarism & Grantmaking | $50.6M | $374.1M |
| 8 | Bradley Turner Foundation INC | Unclassified | $39.1M | $111.9M |
| 9 | Enrichment Services Program Incorporated | Human Services | $31.6M | $5.1M |
| 10 | Beloco Foundation INC | Unclassified | $30.4M | $24.2M |
| 11 | New Horizons Area Mh-mr-sa Program | Health Care | $23.1M | $12.1M |
| 12 | Magnolia Manor of Columbus INC | Health Care | $22.7M | $39.8M |
| 13 | Brookstone School INC | Education | $21.4M | $74.1M |
| 14 | Medical Center Hospital Authority | Health Care | $21.3M | $81.2M |
| 15 | Teen Challenge of Florida INC | Unclassified | $20.7M | $39.1M |
| 16 | Columbus Hospice INC | Unclassified | $20.5M | $9.2M |
| 17 | Columbus State University Foundation INC | Education | $18.8M | $140.2M |
| 18 | W L Amos Sr Foundation INC | Philanthropy, Voluntarism & Grantmaking | $16.1M | $16.0M |
| 19 | The Columbus Museum INC | Arts, Culture & Humanities | $15.7M | $69.3M |
| 20 | Pezold Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $15.0M | $14.4M |
| 21 | Columbus Regional Medical Foundation INC | Health Care | $13.9M | $27.8M |
| 22 | Power Works Industries INC | Human Services | $13.4M | $5.7M |
| 23 | Foundation Properties INC | Education | $12.5M | $37.8M |
| 24 | Daniel P Amos Family Foundation INC | Unclassified | $12.5M | $88.8M |
| 25 | Valley Healthcare System INC | Unclassified | $12.0M | $13.2M |
| 26 | United Way of the Chattahoochee Valley INC | Philanthropy, Voluntarism & Grantmaking | $11.6M | $15.3M |
| 27 | Teen Challenge Job Training INC | Religion-Related | $11.2M | $7.5M |
| 28 | Columbus Affordable Housing Services INC | Housing & Shelter | $11.1M | $32.2M |
| 29 | Pickett & Hatcher Educational Fund Incorporated | Education | $10.6M | $81.2M |
| 30 | Green Island Country Club INC | Unclassified | $10.2M | $10.5M |
| 31 | Boys and Girls Clubs of the Chattahoochee Valley INC | Youth Development | $10.1M | $16.4M |
| 32 | Columbus Regional Healthcare System INC | Health Care | $9.7M | $312.3M |
| 33 | Columbus Housing Initiative INC | Housing & Shelter | $9.4M | $39.2M |
| 34 | Country Club of Columbus INC | Unclassified | $9.1M | $7.6M |
| 35 | Springer Opera House Arts Association INC | Arts, Culture & Humanities | $9.0M | $22.0M |
| 36 | Pastoral Institute Foundation | Mental Health & Crisis Intervention | $8.7M | $14.8M |
| 37 | National Infantry Museum Foundation INC | Arts, Culture & Humanities | $8.2M | $75.4M |
| 38 | Columbus Technical Institute Foundation INC | Unclassified | $7.9M | $14.4M |
| 39 | Sam Spiegel Foundation INC | Unclassified | $7.5M | $16.8M |
| 40 | The Paul S & Jean R Amos Family Foundation | Unclassified | $6.7M | $37.6M |
| 41 | Se Belcher Jr Private Foundation No 3 | Philanthropy, Voluntarism & Grantmaking | $6.2M | $12.5M |
| 42 | Valley Rescue Mission INC | Housing & Shelter | $5.8M | $13.4M |
| 43 | Mercymed of Columbus | Health Care | $5.2M | $8.6M |
| 44 | Young Mens Christian Association Columbus | Unclassified | $4.8M | $18.6M |
| 45 | Paws Humane INC | Animal-Related | $4.6M | $7.7M |
| 46 | Pastoral Institute INC | Unclassified | $4.5M | $5.9M |
| 47 | B&gc Endowment Foundation INC | Philanthropy, Voluntarism & Grantmaking | $4.4M | $12.1M |
| 48 | Great Kids INC | Human Services | $4.4M | $4.6M |
| 49 | Mildred Miller Fort Foundation INC | Unclassified | $4.3M | $23.0M |
| 50 | Historic Columbus Foundation INC | Unclassified | $4.3M | $15.4M |
| 51 | James Hyde Porter Testamentary | Unclassified | $4.3M | $10.0M |
| 52 | Global Teen Challenge INC | Mental Health & Crisis Intervention | $4.2M | $2.6M |
| 53 | Rivercenter INC | Arts, Culture & Humanities | $4.1M | $4.4M |
| 54 | Calvary Community INC III | Housing & Shelter | $4.0M | $2.5M |
| 55 | Truth Spring Incorporated | Community Improvement & Capacity Building | $3.9M | $3.8M |
| 56 | The Hughston Foundation INC | Unclassified | $3.7M | $5.0M |
| 57 | Andrew & Cleo Voight Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $3.5M | $4.4M |
| 58 | John P & Dorothy S Illges Foundation INC | Unclassified | $3.5M | $8.0M |
| 59 | Open Door Community House INC | Human Services | $3.3M | $6.6M |
| 60 | Sarah H and Jack C Hughston Foundation INC | Unclassified | $3.0M | $20K |
| 61 | Columbus Alliance for Battered Women INC | Human Services | $2.5M | $1.9M |
| 62 | Greater Columbus Chamber of Commerce | Unclassified | $2.4M | $2.4M |
| 63 | Lockwood Partners Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.4M | $2.4M |
| 64 | Girls Club of Columbus Endowment Fund Ua Dtd 010986 | Unclassified | $2.3M | $2.4M |
| 65 | George H Buck Jr Jazzology Foundation INC | Arts, Culture & Humanities | $2.3M | $4.3M |
| 66 | The@heracles Group INC | Food, Agriculture & Nutrition | $2.2M | $4K |
| 67 | Hopegivers International INC | Religion-Related | $2.2M | $1.7M |
| 68 | Chattahoochee Valley Jail Ministry INC | Religion-Related | $2.2M | $1.1M |
| 69 | This Works INC | Human Services | $2.1M | $908K |
| 70 | Zion Foundation | Human Services | $2.1M | $1.9M |
| 71 | Columbus Board of Realtors INC | Unclassified | $2.1M | $2.1M |
| 72 | 1909 Preservation Society INC | Arts, Culture & Humanities | $2.1M | $1.8M |
| 73 | Virginia Kimbrough Clark Reese & Thomas Matt Reese Trust | Philanthropy, Voluntarism & Grantmaking | $2.0M | $23.9M |
| 74 | Lower Chattahoochee Direct Service Corp. | Human Services | $2.0M | $4.0M |
| 75 | Columbus Area Hfh | Unclassified | $1.9M | $4.3M |
| 76 | Global Student Initiatives | Religion-Related | $1.9M | $529K |
| 77 | The@norman and Emmy Lou Illges Foundation | Philanthropy, Voluntarism & Grantmaking | $1.8M | $2.6M |
| 78 | Muscogee Educational Excellence Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.8M | $2.7M |
| 79 | Columbus State Universtiy Athletic Fund INC | Education | $1.7M | $4.6M |
| 80 | Gateways Foundation INC | Community Improvement & Capacity Building | $1.7M | $2.5M |
| 81 | Stewart Community Home INC | Unclassified | $1.6M | $1.2M |
| 82 | John Beverly Amos & Elena Diaz-verson Amos Foundation INC | Unclassified | $1.5M | $3.7M |
| 83 | Aflac Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.5M | $108K |
| 84 | Ugrow INC | Environment | $1.5M | $176K |
| 85 | Aflac Childhood Cancer Foundation INC | Diseases, Disorders & Medical Disciplines | $1.4M | $124K |
| 86 | The Columbus Botanical Gardens INC | Environment | $1.4M | $7.5M |
| 87 | First Baptist Properties INC | Unclassified | $1.4M | $3.9M |
| 88 | House of T I M E Incorporated | Mental Health & Crisis Intervention | $1.3M | $258K |
| 89 | George S & Edna L Cobb Foundation INC | Unclassified | $1.3M | $1.6M |
| 90 | Columbus Regional Tennis Assoc INC | Recreation & Sports | $1.3M | $3.4M |
| 91 | Women Networking in Electronic Transactions | Employment | $1.3M | $490K |
| 92 | J W & Ethel I Woodruff Foundation | Unclassified | $1.3M | $10.1M |
| 93 | Friends of Columbus Subaccount Tr K-a Columbus 96 12291994 | Unclassified | $1.3M | $7.5M |
| 94 | Greater Columbus Sports & Events Council INC | Recreation & Sports | $1.3M | $823K |
| 95 | Calvary Community INC | Housing & Shelter | $1.2M | $2.5M |
| 96 | Columbus Economic Development Corporation | Community Improvement & Capacity Building | $1.2M | $12.4M |
| 97 | Girls Incorporated of Columbus and Phenix-russell | Youth Development | $1.2M | $6.4M |
| 98 | Emily Woodruff-glesca Marshall Tr | Unclassified | $1.0M | $1.4M |
| 99 | Boy Scouts of America | Unclassified | $1.0M | $8.6M |
| 100 | Uptown Columbus INC | Community Improvement & Capacity Building | $1.0M | $1.3M |