| 1 | Albert L Ueltschi Foundation | Philanthropy, Voluntarism & Grantmaking | $128.1M | $267.2M |
| 2 | Whole Family Health Center INC | Health Care | $46.4M | $28.8M |
| 3 | The Moorings Club INC | Unclassified | $40.4M | $65.9M |
| 4 | Indian River Community Foundation | Philanthropy, Voluntarism & Grantmaking | $33.6M | $94.0M |
| 5 | Harbor Branch Oceanographic Institution Foundation INC | Science & Technology | $23.4M | $129.5M |
| 6 | Visiting Nurse Association & Hospice Foundation INC | Health Care | $22.4M | $38.4M |
| 7 | United Against Poverty INC | Unclassified | $22.2M | $23.8M |
| 8 | Saint Edwards School | Education | $21.5M | $57.3M |
| 9 | Vna Hospice of Indian River County INC | Unclassified | $20.8M | $23.1M |
| 10 | Habitat for Humanity International INC | Unclassified | $18.6M | $21.8M |
| 11 | Vero Beach Museum of Art INC | Arts, Culture & Humanities | $18.5M | $49.3M |
| 12 | Riverside Theatre INC | Arts, Culture & Humanities | $18.0M | $56.8M |
| 13 | Senior Resource Association INC | Human Services | $15.5M | $7.4M |
| 14 | Visiting Nurse Association of the Treasure Coast INC | Health Care | $15.2M | $9.0M |
| 15 | Frazza Family Foundation INC | Unclassified | $11.5M | $29.7M |
| 16 | Visiting Nurse Association of Indian River County INC | Health Care | $10.2M | $1.3M |
| 17 | Marvin H Davidson Foundation INC | Unclassified | $9.3M | $19.4M |
| 18 | Indian River Charter High School INC | Education | $8.7M | $17.7M |
| 19 | David and Vickie Smick Foundation | Philanthropy, Voluntarism & Grantmaking | $8.7M | $25.2M |
| 20 | Vero Beach Country Club INC | Unclassified | $8.3M | $12.3M |
| 21 | Riomar Country Club | Unclassified | $8.1M | $20.8M |
| 22 | United Way Foundation of Indian River County INC | Philanthropy, Voluntarism & Grantmaking | $7.3M | $7.2M |
| 23 | Bent Pine Golf Club INC | Unclassified | $7.2M | $9.9M |
| 24 | Vero Beach Museum of Art Foundation | Arts, Culture & Humanities | $7.0M | $41.3M |
| 25 | New Indian River Club INC | Recreation & Sports | $6.9M | $10.4M |
| 26 | The Sexton Family Foundation | Philanthropy, Voluntarism & Grantmaking | $6.9M | $15.0M |
| 27 | Childcare Resources of Indian River INC | Human Services | $6.6M | $16.1M |
| 28 | Treasure Coast Homeless Service Council INC | Human Services | $6.4M | $5.2M |
| 29 | United Way of Indian River County INC | Philanthropy, Voluntarism & Grantmaking | $6.3M | $3.9M |
| 30 | Welsh Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $6.2M | $4.9M |
| 31 | Economic Opportunities Council of Indian River County INC | Community Improvement & Capacity Building | $6.0M | $1.7M |
| 32 | The Housing League INC | Housing & Shelter | $5.3M | $4.6M |
| 33 | Marvin Davidson Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $5.2M | $5.2M |
| 34 | Humane Society of Vero Beach Fla | Animal-Related | $5.1M | $6.7M |
| 35 | Pass It on to Kids Foundation | Philanthropy, Voluntarism & Grantmaking | $4.8M | $18.7M |
| 36 | The Learning Alliance INC | Education | $4.8M | $5.8M |
| 37 | Denise & Tony Gorman Family Foundation | Philanthropy, Voluntarism & Grantmaking | $4.7M | $3.9M |
| 38 | McKee Botanical Garden INC | Environment | $4.6M | $24.0M |
| 39 | Indian River Hospital Foundation INC | Health Care | $4.4M | $37.4M |
| 40 | Rosswood Foundation | Philanthropy, Voluntarism & Grantmaking | $4.4M | $10.2M |
| 41 | Kim and Larry Lubeck Foundation | Human Services | $4.3M | $8.4M |
| 42 | Foundation 33 11 | Philanthropy, Voluntarism & Grantmaking | $4.2M | $17.4M |
| 43 | Oak Harbor Club Vero Beach INC | Recreation & Sports | $4.0M | $2.4M |
| 44 | Graymer Phoenix Foundation | Philanthropy, Voluntarism & Grantmaking | $4.0M | $4.0M |
| 45 | Indian River County Healthy Start Coalition INC | Health Care | $3.9M | $3.9M |
| 46 | The Arc of Indian River County INC | Human Services | $3.8M | $4.8M |
| 47 | Crossover Mission INC | Youth Development | $3.7M | $11.0M |
| 48 | Kurt & Marilyn Wallach Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.6M | $1K |
| 49 | North County Charter School INC | Education | $3.6M | $9.2M |
| 50 | Johns Island Community Service League | Unclassified | $3.6M | $3.7M |
| 51 | Scholarship Foundation of Indian River County INC | Unclassified | $3.5M | $14.5M |
| 52 | E William and France Kenyon Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.5M | $20.3M |
| 53 | Center for the Study of the International Economy INC | Education | $3.5M | $14.5M |
| 54 | Vero Beach Yacht Club | Unclassified | $3.3M | $4.0M |
| 55 | Indian River Land Tr INC | Environment | $3.3M | $38.2M |
| 56 | The Hope for Families Center INC | Human Services | $3.3M | $10.1M |
| 57 | Masters Academy of Vero Beach INC | Education | $3.3M | $2.2M |
| 58 | Schell Family Foundation | Philanthropy, Voluntarism & Grantmaking | $3.1M | $5.4M |
| 59 | Mental Health Association in Indian River County INC | Unclassified | $3.1M | $2.7M |
| 60 | Gifford Youth Achievement Center INC | Human Services | $3.0M | $7.5M |
| 61 | Vna Space Coast INC | Health Care | $2.9M | $306K |
| 62 | Boys & Girls Club of Indian River County INC | Youth Development | $2.9M | $9.2M |
| 63 | Humane Society of Vero Beach & Indian River County Fl Foundation | Animal-Related | $2.8M | $10.4M |
| 64 | Janke Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $2.8M | $7.9M |
| 65 | Scott and Susan Davidson Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.7M | $3.1M |
| 66 | Ocean Research & Conservation Association INC | Environment | $2.7M | $4.2M |
| 67 | Thrive Irc INC | Mental Health & Crisis Intervention | $2.5M | $1.9M |
| 68 | Youth Sailing Foundation of Indian River County | Recreation & Sports | $2.5M | $8.9M |
| 69 | Vero Classical School | Education | $2.3M | $1.5M |
| 70 | Gifford Youth Achievement Center Foundation INC | Youth Development | $2.3M | $6.7M |
| 71 | Kleinschmidt Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.2M | $10.8M |
| 72 | Hawkins Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.2M | $2.3M |
| 73 | Hastings Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.2M | $446K |
| 74 | Hauser Family Foundation INC | Human Services | $2.1M | $3.4M |
| 75 | Enviromental Learning Center INC | Environment | $2.0M | $5.2M |
| 76 | Macauley and Helen Dow Whiting Foundation | Unclassified | $1.8M | $3.5M |
| 77 | Vero Beach Lodge No 1822 Loyal Order of Moose | Unclassified | $1.7M | $1.1M |
| 78 | Indian River County Chamber of Commerce INC | Unclassified | $1.6M | $983K |
| 79 | Cornelia Warren Community Assn INC | Youth Development | $1.6M | $5.1M |
| 80 | Youth Guidance of Indian River County INC | Human Services | $1.6M | $3.3M |
| 81 | Squier Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.6M | $6.8M |
| 82 | Kt Family Foundation | Unclassified | $1.6M | $3.1M |
| 83 | Boys & Girls Clubs Foundation of Indian River County INC | International, Foreign Affairs & National Security | $1.6M | $6.1M |
| 84 | Womens Care Center of Irc INC | Human Services | $1.5M | $5.4M |
| 85 | Loftis Foundation INC | Unclassified | $1.5M | $8.0M |
| 86 | Association for Computers in Mathematics and Science Teaching | Unclassified | $1.4M | $630K |
| 87 | Archie S Wingfield Jr Charitable Tr Under Ex a Para E of Archie S W | Education | $1.4M | $4.0M |
| 88 | Realtors Association of Indian River County | Unclassified | $1.4M | $6.5M |
| 89 | St. Peters Academy INC | Education | $1.4M | $1.0M |
| 90 | The Peter Dartley Charitable Trust | Arts, Culture & Humanities | $1.4M | $3.6M |
| 91 | Eugene and Carol Atkinson Family Foundation | Unclassified | $1.4M | $1.2M |
| 92 | Fraternal Order of Eagles | Unclassified | $1.3M | $28K |
| 93 | Leo and Yuki Graham Foundation | Philanthropy, Voluntarism & Grantmaking | $1.3M | $4.3M |
| 94 | High Poplars Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.3M | $2.9M |
| 95 | Indian River Symphonic Association INC | Arts, Culture & Humanities | $1.3M | $1.5M |
| 96 | Holmes Foundation INC | Unclassified | $1.3M | $1.5M |
| 97 | Quail Valley Charities INC | Philanthropy, Voluntarism & Grantmaking | $1.2M | $961K |
| 98 | Womens Refuge of Vero Beach INC | Human Services | $1.2M | $1.0M |
| 99 | Corry Family Foundation | Philanthropy, Voluntarism & Grantmaking | $1.2M | $6.4M |
| 100 | Atlantic Classical Orchestra INC | Arts, Culture & Humanities | $1.2M | $2.1M |