| 1 | Booth Foundation | Philanthropy, Voluntarism & Grantmaking | $63.4M | $88.8M |
| 2 | Hospice of the Treasure Coast INC | Unclassified | $28.2M | $8.9M |
| 3 | Visiting Nurse Association of Florida INC | Unclassified | $24.2M | $19.8M |
| 4 | Early Learning Coalition of Indian River Martin & Okeechobee Counties | Education | $23.9M | $3.0M |
| 5 | Hospice of Martin & St. Lucie INC | Human Services | $20.2M | $8.5M |
| 6 | Health and Palliative Services of the Treasure Coast INC | Human Services | $17.2M | $3.6M |
| 7 | United Way of Martin County Foundation INC | Philanthropy, Voluntarism & Grantmaking | $16.4M | $8.2M |
| 8 | The Hospice Foundation of Martin & St. Lucie INC | Unclassified | $15.9M | $41.4M |
| 9 | Treasure Coast Classical Academy INC | Education | $13.0M | $22.1M |
| 10 | Advocates for the Rights of the Challenged of the Treasured Coast | Human Services | $12.1M | $7.7M |
| 11 | Robert P & Patricia J Bauman Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $12.0M | $15.1M |
| 12 | The Council on Aging of Martin County INC | Unclassified | $10.5M | $14.7M |
| 13 | Community Foundation Martin St. Lucie INC | Human Services | $10.5M | $63.6M |
| 14 | Jesus House of Hope INC | Human Services | $9.1M | $6.7M |
| 15 | Russell and Jane Stern Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $8.5M | $8.0M |
| 16 | Volunteers in Medicine Clinic INC | Health Care | $6.9M | $158K |
| 17 | Visiting Nurse Community Care of the West Coast INC | Health Care | $6.6M | $1.6M |
| 18 | The Grace & Hope Foundation | Philanthropy, Voluntarism & Grantmaking | $6.6M | $11.6M |
| 19 | Tykes & Teens INC | Mental Health & Crisis Intervention | $6.2M | $2.0M |
| 20 | Marine Science Foundation | Science & Technology | $6.0M | $10.9M |
| 21 | Sailfish Point Golf Club | Recreation & Sports | $5.5M | $17.8M |
| 22 | Hope Center for Autism INC | Education | $5.2M | $4.3M |
| 23 | Young Mens Christian Association of the Treasure Coast Florida INC | Human Services | $5.1M | $6.9M |
| 24 | Carol M Jacobsohn Foundation | Unclassified | $4.7M | $8.9M |
| 25 | E G Watkins Family Foundation | Philanthropy, Voluntarism & Grantmaking | $4.6M | $84K |
| 26 | Freed Foundation INC | Unclassified | $4.5M | $15.2M |
| 27 | Safespace INC | Human Services | $4.0M | $5.3M |
| 28 | Habitat for Humanity International INC | Unclassified | $3.8M | $6.8M |
| 29 | Florida Oceanographic Society INC | Science & Technology | $3.7M | $11.1M |
| 30 | Moriarty Fam Charitable Foundation Tr | Philanthropy, Voluntarism & Grantmaking | $3.7M | $6.3M |
| 31 | Miles Grant Country Club INC | Unclassified | $3.6M | $5.1M |
| 32 | Friends of the Lyric INC | Arts, Culture & Humanities | $3.4M | $6.4M |
| 33 | Charles F Chapman School of Seamanship INC | Science & Technology | $2.9M | $5.2M |
| 34 | United Way of Martin County INC | Philanthropy, Voluntarism & Grantmaking | $2.7M | $3.1M |
| 35 | Core Program INC | Crime & Legal-Related | $2.6M | $968K |
| 36 | Martin County Health Start Coalition INC | Health Care | $2.2M | $1.1M |
| 37 | Andrassy Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.0M | $1.9M |
| 38 | Operation 300 INC | Youth Development | $2.0M | $3.3M |
| 39 | Historical Society of Martin County INC | Unclassified | $1.9M | $12.9M |
| 40 | Friends of the Everglades INC | Environment | $1.9M | $1.8M |
| 41 | Martin County Realtors of the Treasure Coast INC | Unclassified | $1.9M | $3.0M |
| 42 | Samuel M and Alma Catsman Foundation | Philanthropy, Voluntarism & Grantmaking | $1.8M | $5.5M |
| 43 | Martin County Agricultural Fair Association INC | Recreation & Sports | $1.6M | $652K |
| 44 | Dubner Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.5M | $5.1M |
| 45 | Stuart Air Show INC | Arts, Culture & Humanities | $1.5M | $670K |
| 46 | Bergin Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.4M | $10.5M |
| 47 | Edward T Bedford Foundation Ima | Philanthropy, Voluntarism & Grantmaking | $1.4M | $12.7M |
| 48 | Doris F Childs Charitable Tr Ua First National Bank & Tr Co Ttee | Philanthropy, Voluntarism & Grantmaking | $1.3M | $3.6M |
| 49 | Light of the World Charities INC | International, Foreign Affairs & National Security | $1.3M | $2.1M |
| 50 | Friends of Volunteers in Medicine Clinic INC | Philanthropy, Voluntarism & Grantmaking | $1.3M | $6.4M |
| 51 | Jsg Amateur Sports Corporation | Recreation & Sports | $1.2M | $466K |
| 52 | Stuart Martin County Chamber of Commerce | Unclassified | $1.2M | $809K |
| 53 | Education Foundation of Martin County INC | Philanthropy, Voluntarism & Grantmaking | $1.2M | $513K |
| 54 | American Legion | Unclassified | $1.2M | $1.0M |
| 55 | Gertrude Walden Child Care Center INC | Education | $1.1M | $23K |
| 56 | Mollys House INC | Unclassified | $1.0M | $3.3M |
| 57 | Family Promise of Martin County | Human Services | $996K | $884K |
| 58 | Marys Shelter of the Treasure Coast INC | Housing & Shelter | $970K | $1.9M |
| 59 | Brain Tumor Research Charity | Medical Research | $927K | $170K |
| 60 | Elev8hope | Human Services | $893K | $1.6M |
| 61 | Ken Duke and Friends INC | Philanthropy, Voluntarism & Grantmaking | $855K | $40K |
| 62 | Carolyn L Donigan Private Foundation INC | Philanthropy, Voluntarism & Grantmaking | $850K | $1.4M |
| 63 | Bauer Charitable Trust | Philanthropy, Voluntarism & Grantmaking | $836K | $5.1M |
| 64 | Nina Haven Scholarships INC | Unclassified | $817K | $4.4M |
| 65 | Sailfish Point Foundation INC | Education | $809K | $2.1M |
| 66 | Friends of the Martin County Library System INC | Education | $759K | $957K |
| 67 | Fraternal Order of Eagles | Unclassified | $720K | $447K |
| 68 | Christian Community Care Center | Health Care | $705K | $187K |
| 69 | Martin United Soccer Club INC | Unclassified | $685K | $644K |
| 70 | Caring Children Clothing Children INC | Human Services | $670K | $793K |
| 71 | Veterans of Foreign Wars of the United States Dept of Florida | Unclassified | $655K | $245K |
| 72 | The Library Foundation of Martin County INC | Education | $626K | $4.4M |
| 73 | Kistler-ritso Foundation | Philanthropy, Voluntarism & Grantmaking | $610K | $4.3M |
| 74 | All About Abcs Learning Center INC | Human Services | $607K | $3K |
| 75 | Random Good Foundation INC | Arts, Culture & Humanities | $605K | $3.4M |
| 76 | International Association of Fire Fighters | Unclassified | $590K | $1.2M |
| 77 | Business Development Board of Martin County INC | Unclassified | $574K | $488K |
| 78 | Richard and June Smith Family Foundation | Philanthropy, Voluntarism & Grantmaking | $553K | $1.5M |
| 79 | Florida Engineering Foundation INC | Unclassified | $542K | $2.1M |
| 80 | Norton and Judy Viny Private Foundation | Unclassified | $536K | $1.3M |
| 81 | The Barn Theatre INC | Arts, Culture & Humanities | $530K | $718K |
| 82 | Southeast Florida Honor Flight INC | Education | $517K | $909K |
| 83 | Heart of God Ministries INC | Religion-Related | $494K | $353K |
| 84 | Stuart Main Street Association INC | Community Improvement & Capacity Building | $470K | $106K |
| 85 | James D & Marilyn Evans Familyfoundation INC | Philanthropy, Voluntarism & Grantmaking | $469K | $488K |
| 86 | Superior Foundation Corp. | Education | $450K | $411K |
| 87 | The M I S S Incorporated of the Treasure Coast | Human Services | $449K | $2.8M |
| 88 | Speak Life Performing Arts Company INC | Youth Development | $419K | $359K |
| 89 | The Arts Council INC | Arts, Culture & Humanities | $404K | $133K |
| 90 | Go Build Love INC | Housing & Shelter | $402K | $52K |
| 91 | Benevolent & Protective Order of Elks of the USA | Unclassified | $369K | $542K |
| 92 | Visiting Nurse Foundation INC | Unclassified | $362K | $4.8M |
| 93 | Annie Appleseed Project | Health Care | $354K | $79K |
| 94 | Mariner Sands Charity Week INC | Public & Societal Benefit | $349K | $41K |
| 95 | International Society of Sports Nutrition INC | Food, Agriculture & Nutrition | $331K | $5K |
| 96 | Martin County Bar Association | Community Improvement & Capacity Building | $328K | $209K |
| 97 | Womans Club of Stuart INC | Community Improvement & Capacity Building | $326K | $226K |
| 98 | Florida Baseball Club INC | Recreation & Sports | $319K | $24K |
| 99 | Access Art | Arts, Culture & Humanities | $317K | $129K |
| 100 | Armstrong Foundation | Philanthropy, Voluntarism & Grantmaking | $314K | $1.1M |