| 1 | McR Health INC | Unclassified | $169.5M | $93.9M |
| 2 | Goodwill Industries Manasota INC | Employment | $148.6M | $163.5M |
| 3 | Centerstone of Florida INC | Health Care | $66.4M | $31.3M |
| 4 | Pentecost Foundation | Philanthropy, Voluntarism & Grantmaking | $52.6M | $62.9M |
| 5 | Michael G Curran Family Foundation | Philanthropy, Voluntarism & Grantmaking | $47.2M | $16.6M |
| 6 | Mary Parker Foundation 25167-0 | Unclassified | $30.5M | $118.4M |
| 7 | State College of Florida Foundation INC | Education | $26.3M | $105.3M |
| 8 | Manatee Community Foundation INC | Philanthropy, Voluntarism & Grantmaking | $24.1M | $62.9M |
| 9 | Episcopal Day Private School of Manatee County INC | Education | $23.0M | $38.2M |
| 10 | William Monroe Rowlett Academy for Arts and Communication | Education | $20.4M | $16.9M |
| 11 | Suncoast Communities Blood Bank INC | Health Care | $19.1M | $21.2M |
| 12 | Team Success a School of Excellence INC | Education | $17.3M | $33.6M |
| 13 | Ralph S French Charitable Foundation Trust | Philanthropy, Voluntarism & Grantmaking | $16.2M | $25.1M |
| 14 | Bradenton Christian School Society INC | Unclassified | $13.6M | $34.4M |
| 15 | Meals on Wheels Plus of Manatee INC | Food, Agriculture & Nutrition | $13.5M | $12.5M |
| 16 | Habitat for Humanity International INC | Unclassified | $11.3M | $15.0M |
| 17 | The Realization Foundation | Philanthropy, Voluntarism & Grantmaking | $8.9M | $25.9M |
| 18 | Tara Golf and Country Club INC | Unclassified | $8.2M | $14.4M |
| 19 | Bradenton Cc INC | Recreation & Sports | $7.9M | $9.0M |
| 20 | Global Serve International INC | Religion-Related | $7.5M | $12.0M |
| 21 | Daniel S Blalock Jr Charitable Foundation Tr Uad 5-13-1988 as Ame | Philanthropy, Voluntarism & Grantmaking | $7.4M | $18.0M |
| 22 | Bishop Museum of Science and Nature INC | Arts, Culture & Humanities | $7.3M | $34.6M |
| 23 | Community Coalition on Homelessness Corporation | Housing & Shelter | $5.9M | $6.4M |
| 24 | Jc Lewis Primary Healthcare Center INC | Health Care | $5.4M | $7.7M |
| 25 | Steve and Natalee Herrig Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $5.3M | $9.8M |
| 26 | Green Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $5.3M | $20.1M |
| 27 | Florida Cultural Group INC | Arts, Culture & Humanities | $5.1M | $19.0M |
| 28 | Humane Society of Manatee County INC | Animal-Related | $5.1M | $10.2M |
| 29 | Manatee Childrens Services Incorporated | Crime & Legal-Related | $5.0M | $2.6M |
| 30 | Boys & Girls Clubs of Manatee County INC | Youth Development | $4.5M | $24.4M |
| 31 | 21ST Century Ministries INC | Religion-Related | $4.3M | $1.1M |
| 32 | Orenda Health and Wellness INC | Health Care | $4.3M | $530K |
| 33 | Bishop Museum of Science and Nature Enndowment Trust | Unclassified | $4.2M | $17.9M |
| 34 | Gettel Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.4M | $12.6M |
| 35 | The Art League of Manatee County | Unclassified | $3.1M | $13.6M |
| 36 | Disabled American Veterans | Unclassified | $3.0M | $1.4M |
| 37 | Second Heart Homes INC | Housing & Shelter | $3.0M | $4.8M |
| 38 | Hope Family Services INC | Unclassified | $2.8M | $4.0M |
| 39 | Manatee County Girls Club INC | Youth Development | $2.5M | $2.1M |
| 40 | Manatee Chamber of Commerce INC | Unclassified | $2.5M | $6.3M |
| 41 | Commission on Adult Basic Education INC | Education | $2.5M | $1.8M |
| 42 | Visible Men Academy INC | Education | $2.4M | $1.3M |
| 43 | Bradenton Missionary Village INC | Housing & Shelter | $2.3M | $4.1M |
| 44 | Galatains 6 2 INC | Religion-Related | $2.3M | $4.3M |
| 45 | Manatee Memorial Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.3M | $1.7M |
| 46 | Capillary Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.2M | $3.6M |
| 47 | St. Stephens Episcopal School Endowment Fund Tr | Philanthropy, Voluntarism & Grantmaking | $2.2M | $8.3M |
| 48 | Taylor Family Foundation INC | Unclassified | $2.1M | $14.3M |
| 49 | Honor Santuary INC | Animal-Related | $2.0M | $7.3M |
| 50 | Women Resource Center of Manatee INC | Human Services | $1.9M | $3.1M |
| 51 | Manatee Education Foundation INC | Unclassified | $1.9M | $1.2M |
| 52 | Loving Hands Ministries INC | Unclassified | $1.9M | $3.5M |
| 53 | The Sunshine Academy and Daycare Corporation | Education | $1.8M | $1.4M |
| 54 | Help to Home INC | Human Services | $1.8M | $5.8M |
| 55 | R M Beall Sr Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $1.8M | $5.4M |
| 56 | Presbyterian Homes of Bradenton INC | Unclassified | $1.7M | $4.0M |
| 57 | Society for the Prevention of Cruelty to Animals of Manatee Co | Unclassified | $1.7M | $4.1M |
| 58 | Foundation for Dreams INC | Diseases, Disorders & Medical Disciplines | $1.7M | $2.8M |
| 59 | Bradenton Area Economic Development Corporation | Community Improvement & Capacity Building | $1.6M | $2.1M |
| 60 | United Community Centers INC | Unclassified | $1.4M | $1.9M |
| 61 | Manatee School of Arts and Sciences INC | Education | $1.4M | $1.3M |
| 62 | Throne of Grace Ministries INC | Religion-Related | $1.4M | $1.6M |
| 63 | Desoto Towers INC | Unclassified | $1.4M | $5.4M |
| 64 | Manasota Solve INC | Human Services | $1.4M | $3.4M |
| 65 | Braden River Soccer Club INC | Recreation & Sports | $1.3M | $983K |
| 66 | The Montessori Foundation Incorporated | Unclassified | $1.3M | $192K |
| 67 | Bradenton Lodge No 1223 Loyal Order of Moose | Unclassified | $1.2M | $2.2M |
| 68 | Exchange Club Family Partnership Center of Manatee County INC | Crime & Legal-Related | $1.2M | $1.4M |
| 69 | Be in McCormack Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.2M | $2.0M |
| 70 | American Legion | Unclassified | $1.1M | $595K |
| 71 | National Football League Referees Association | Unclassified | $1.0M | $3.4M |
| 72 | Hernando Desoto Historical Society INC | Unclassified | $971K | $181K |
| 73 | National Association of Fire Investigators | Unclassified | $944K | $263K |
| 74 | Bailes Consulting Services INC | Education | $917K | $873K |
| 75 | Hearts Afire INC | International, Foreign Affairs & National Security | $869K | $50K |
| 76 | Suncoast Youth for Christ INC | Youth Development | $869K | $1.5M |
| 77 | International Brotherhood of Teamsters | Unclassified | $855K | $1.5M |
| 78 | Realize Bradenton INC | Arts, Culture & Humanities | $816K | $439K |
| 79 | Bomberger Foundation INC | Philanthropy, Voluntarism & Grantmaking | $812K | $3.5M |
| 80 | Minorities in Shark Sciences | Education | $799K | $452K |
| 81 | The Police Athletic League of Manatee County INC | Youth Development | $780K | $137K |
| 82 | Benevolent & Protective Order of Elks of the USA | Unclassified | $751K | $2.5M |
| 83 | Kiwanis International INC | Unclassified | $739K | $1.0M |
| 84 | Oasis Middle School INC | Education | $738K | $2.0M |
| 85 | Tampa Bay Junior Hockey INC | Recreation & Sports | $725K | $180K |
| 86 | The Foundation for the Boys & Girls Clubs INC | Youth Development | $722K | $15.1M |
| 87 | Benevolent & Protective Order of Elks of the USA | Unclassified | $720K | $929K |
| 88 | Book Manufacturers Institute INC | Unclassified | $697K | $628K |
| 89 | Lakewood Ranch Community Activities INC | Community Improvement & Capacity Building | $670K | $330K |
| 90 | Veterans of Foreign Wars of the United States Dept of Florida | Unclassified | $666K | $301K |
| 91 | Saving the Sunshine State | Housing & Shelter | $648K | $1.6M |
| 92 | International Chain Salon Association | Unclassified | $637K | $202K |
| 93 | Glasgow Foundation | Education | $635K | $762K |
| 94 | Benevolent & Protective Order of Elks of the USA | Unclassified | $626K | $1.2M |
| 95 | Bradenton Dream Center INC | Religion-Related | $625K | $34K |
| 96 | Our Daily Bread of Bradenton INC | Unclassified | $584K | $1.3M |
| 97 | Ave Maria University Preparatory School INC | Education | $574K | $98K |
| 98 | Img Academy Foundation INC | Philanthropy, Voluntarism & Grantmaking | $571K | $401K |
| 99 | Also for Gay Youth INC | Civil Rights, Social Action & Advocacy | $531K | $658K |
| 100 | Manatee Educational Television Consortium INC | Arts, Culture & Humanities | $521K | $546K |