| 1 | Shelby Cullom Davis Charitable Fund INC | Philanthropy, Voluntarism & Grantmaking | $36.6B | $3.1B |
| 2 | Astrazeneca Patient Assistance Organization | Health Care | $4.6B | $0 |
| 3 | Christiana Care Health Services INC | Health Care | $3.9B | $4.8B |
| 4 | Ge Li & Ning Zhao Family Foundation | Philanthropy, Voluntarism & Grantmaking | $844.2M | $309.6M |
| 5 | American Gift Fund | Philanthropy, Voluntarism & Grantmaking | $495.1M | $642.6M |
| 6 | John & Tami Marick Foundation INC | Philanthropy, Voluntarism & Grantmaking | $254.6M | $408.4M |
| 7 | William T and Frances a Little Foundation | Philanthropy, Voluntarism & Grantmaking | $253.0M | $261.8M |
| 8 | Aurora Foundation | Philanthropy, Voluntarism & Grantmaking | $250.3M | $674.3M |
| 9 | The Champlin Foundation | Unclassified | $232.7M | $456.6M |
| 10 | Union Hospital of Cecil County | Health Care | $210.2M | $209.2M |
| 11 | Smilow Foundation INC | Philanthropy, Voluntarism & Grantmaking | $201.0M | $165.9M |
| 12 | St. Francis Hospital INC | Health Care | $161.8M | $75.6M |
| 13 | Five Pointe Professional Liability Insurance Company | Health Care | $153.4M | $437.3M |
| 14 | The Grateful Lives Foundation | Philanthropy, Voluntarism & Grantmaking | $151.7M | $1.1B |
| 15 | Brandt Jackson Foundation | Philanthropy, Voluntarism & Grantmaking | $125.9M | $69.6M |
| 16 | Longwood Foundation INC | Philanthropy, Voluntarism & Grantmaking | $123.0M | $967.5M |
| 17 | Essex Avenue Foundation | Philanthropy, Voluntarism & Grantmaking | $108.3M | $616.1M |
| 18 | Morgridge Family Foundation | Philanthropy, Voluntarism & Grantmaking | $93.0M | $243.9M |
| 19 | Head & Heart Foundation Tr | Philanthropy, Voluntarism & Grantmaking | $91.9M | $245.4M |
| 20 | Band Foundation | Philanthropy, Voluntarism & Grantmaking | $86.6M | $147.8M |
| 21 | Delaware Community Foundation | Philanthropy, Voluntarism & Grantmaking | $79.8M | $346.1M |
| 22 | Daniel G and Wanda K Odell Family Foundation | Philanthropy, Voluntarism & Grantmaking | $78.5M | $10.4M |
| 23 | Moccasin Lake Foundation | Unclassified | $76.6M | $107.0M |
| 24 | Raskob Foundation for Catholic Activities Incorporated | Unclassified | $74.8M | $208.0M |
| 25 | La Vida Feliz Foundation | Philanthropy, Voluntarism & Grantmaking | $72.3M | $376.6M |
| 26 | American Electric Power Foundation | Philanthropy, Voluntarism & Grantmaking | $71.3M | $65.2M |
| 27 | Institute of Cubergy Interactions Ici INC | Education | $70.2M | $20.2M |
| 28 | Ejk Foundation | Philanthropy, Voluntarism & Grantmaking | $65.7M | $51.9M |
| 29 | Welfare Foundation INC | Unclassified | $65.5M | $106.7M |
| 30 | Pincus Family Fund | Philanthropy, Voluntarism & Grantmaking | $63.4M | $100.0M |
| 31 | Barry and Mimi Sternlicht Foundation | Philanthropy, Voluntarism & Grantmaking | $61.2M | $52.4M |
| 32 | Sunrise Project INC | Environment | $61.1M | $14.0M |
| 33 | J B L Scholarship Trust | Unclassified | $60.9M | $10.4M |
| 34 | Lumena Foundation | Philanthropy, Voluntarism & Grantmaking | $60.1M | $30.3M |
| 35 | Goodwill Industries of Delaware & Delaware County INC | Employment | $58.0M | $53.2M |
| 36 | Jhc Foundation | Philanthropy, Voluntarism & Grantmaking | $57.7M | $114.0M |
| 37 | Young Mens Christian Association of Delaware | Human Services | $56.3M | $112.1M |
| 38 | Horizon Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $56.2M | $120.9M |
| 39 | Lytton-kambara Foundation | Philanthropy, Voluntarism & Grantmaking | $55.4M | $71.5M |
| 40 | Goldey Beacom College INC | Education | $53.9M | $243.5M |
| 41 | The Linda and Mike Mussallem Foundation | Philanthropy, Voluntarism & Grantmaking | $52.1M | $81.8M |
| 42 | Robert and Ardis James Foundation INC | Philanthropy, Voluntarism & Grantmaking | $51.3M | $169.6M |
| 43 | Stella Roy Foundation | Philanthropy, Voluntarism & Grantmaking | $49.8M | $77.0M |
| 44 | Louis and Anne Abrons Foundation INC | Unclassified | $49.4M | $125.9M |
| 45 | Kay Family Foundation | Philanthropy, Voluntarism & Grantmaking | $47.7M | $15.5M |
| 46 | Grant-making Foundation | Philanthropy, Voluntarism & Grantmaking | $45.5M | $22.6M |
| 47 | Christiana Care Home Health and Community Services INC | Health Care | $45.3M | $23.9M |
| 48 | Tower Hill School | Education | $45.1M | $125.4M |
| 49 | Swenson Family Foundation | Philanthropy, Voluntarism & Grantmaking | $42.8M | $43.4M |
| 50 | Broadcom Foundation | Philanthropy, Voluntarism & Grantmaking | $42.7M | $94.1M |
| 51 | Odyssey Charter School Incorporated | Education | $42.3M | $80.9M |
| 52 | Jaggers Family Foundation | Philanthropy, Voluntarism & Grantmaking | $42.2M | $53.2M |
| 53 | Psquared Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $41.6M | $107.8M |
| 54 | The Barry S Sternlicht Foundation | Philanthropy, Voluntarism & Grantmaking | $41.6M | $170.3M |
| 55 | Nova Vista Foundation | Philanthropy, Voluntarism & Grantmaking | $41.3M | $40.8M |
| 56 | The Timothy and Susanne Sullivan Family Foundation | Philanthropy, Voluntarism & Grantmaking | $41.2M | $20.8M |
| 57 | Homer Skelton Charitable Foundation | Education | $40.2M | $58.3M |
| 58 | Pincus Family Foundation | Philanthropy, Voluntarism & Grantmaking | $38.4M | $103.9M |
| 59 | M K Reichert Sternlicht Foundation | Philanthropy, Voluntarism & Grantmaking | $38.2M | $100.0M |
| 60 | The Monarch Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $37.6M | $109.2M |
| 61 | Herbert and Nell Singer Foundation INC | Unclassified | $37.5M | $60.9M |
| 62 | Life at St. Francis Healthcare INC | Unclassified | $37.2M | $33.9M |
| 63 | David and Janet Polak Foundation | Philanthropy, Voluntarism & Grantmaking | $36.9M | $70.4M |
| 64 | Donald J Slavik Family Foundation | Philanthropy, Voluntarism & Grantmaking | $36.6M | $85.3M |
| 65 | Whitcomb Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $36.4M | $19.6M |
| 66 | Wounded Warrior Project Long Term Support Tr | Human Services | $35.8M | $171.7M |
| 67 | Boys and Girls Club of Delaware INC | Unclassified | $35.2M | $57.2M |
| 68 | Efrusy Family Foundation | Philanthropy, Voluntarism & Grantmaking | $35.0M | $85.0M |
| 69 | Earl and Kathryn Congdon Family Foundation | Philanthropy, Voluntarism & Grantmaking | $34.6M | $88.9M |
| 70 | Westside Family Healthcare INC | Unclassified | $34.3M | $26.2M |
| 71 | Charles R Wood Foundation | Unclassified | $34.0M | $45.7M |
| 72 | The Margeret Ellen Nielsen Foundation | Philanthropy, Voluntarism & Grantmaking | $33.0M | $21.5M |
| 73 | Children and Families First Delaware INC | Human Services | $32.5M | $13.3M |
| 74 | Philip F Dupont Tr Ud for University of Virginia 1028-2 Nect | Education | $32.5M | $92.1M |
| 75 | Aec Trust | Unclassified | $31.9M | $36.8M |
| 76 | Reiner Family Foundation | Philanthropy, Voluntarism & Grantmaking | $31.6M | $61.1M |
| 77 | Dow Kim Family Foundation Corporation | Philanthropy, Voluntarism & Grantmaking | $31.0M | $745K |
| 78 | Oechsle Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $30.5M | $59.5M |
| 79 | Feigin Foundation | Philanthropy, Voluntarism & Grantmaking | $30.0M | $30.0M |
| 80 | The Singer Family Charitable Foundation | Unclassified | $29.6M | $14.9M |
| 81 | Delaware Art Museum | Arts, Culture & Humanities | $29.4M | $54.1M |
| 82 | Ruth Lilly Philanthropic Foundation | Philanthropy, Voluntarism & Grantmaking | $28.8M | $90.6M |
| 83 | Double T Family Foundation | Philanthropy, Voluntarism & Grantmaking | $28.7M | $10.3M |
| 84 | The White Horse Group Foundation INC | Philanthropy, Voluntarism & Grantmaking | $28.1M | $55.9M |
| 85 | Passport Foundation | Philanthropy, Voluntarism & Grantmaking | $28.0M | $62.7M |
| 86 | Bess Spiva Timmons Foundation INC | Unclassified | $27.4M | $2.2M |
| 87 | Tseng-rust Family Foundation | Philanthropy, Voluntarism & Grantmaking | $27.1M | $57.9M |
| 88 | Seven Seas Community Foundation | Philanthropy, Voluntarism & Grantmaking | $26.8M | $27.2M |
| 89 | Bharat Family Foundation | Philanthropy, Voluntarism & Grantmaking | $26.5M | $31.5M |
| 90 | J M McDonald Foundation INC | Unclassified | $26.3M | $29.8M |
| 91 | Dunn Foundation | Unclassified | $26.3M | $92.6M |
| 92 | Laurie Kayden Foundation | Unclassified | $26.0M | $66.0M |
| 93 | Jades Foundation | Philanthropy, Voluntarism & Grantmaking | $25.9M | $3.5M |
| 94 | Winston Family Initiative in Tech & Adolsecent Brain Development INC | Philanthropy, Voluntarism & Grantmaking | $25.7M | $23.4M |
| 95 | Noubar & Anna Afeyan Foundation | Philanthropy, Voluntarism & Grantmaking | $25.6M | $10.3M |
| 96 | Reissa Foundation | Philanthropy, Voluntarism & Grantmaking | $25.6M | $66.4M |
| 97 | Riedman Foundation | Unclassified | $25.2M | $42.6M |
| 98 | Schmetterling Foundation | Philanthropy, Voluntarism & Grantmaking | $25.0M | $42.0M |
| 99 | Lee INC | Education | $24.9M | $3.6M |
| 100 | Lorna Jordan Charitable Organization | Philanthropy, Voluntarism & Grantmaking | $24.5M | $51.6M |