| 1 | University of Delaware | Unclassified | $3.0B | $4.6B |
| 2 | American Online Giving Foundation INC | Philanthropy, Voluntarism & Grantmaking | $2.1B | $269.5M |
| 3 | Emmet Family Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $56.7M | $62.3M |
| 4 | Food Bank of Delaware INC | Food, Agriculture & Nutrition | $53.4M | $60.6M |
| 5 | Aspira of Delaware Charter Operations | Education | $32.9M | $72.1M |
| 6 | Delaware Hospice INC | Human Services | $28.6M | $40.8M |
| 7 | Giving What We Can USA INC | Philanthropy, Voluntarism & Grantmaking | $27.9M | $22.0M |
| 8 | Exceptional Care for Children INC | Health Care | $23.2M | $47.6M |
| 9 | Academia Antonia Alonso | Education | $17.0M | $43.1M |
| 10 | Girl Scouts of the Chesapeake Bay Council INC | Youth Development | $15.3M | $11.4M |
| 11 | Independence School INC | Unclassified | $13.8M | $29.1M |
| 12 | Delaware Life and Health Insurance Guaranty Assn. | Unclassified | $13.2M | $5.5M |
| 13 | Newark Emergency Center INC | Health Care | $10.5M | $4.9M |
| 14 | Kendal Corporation | Health Care | $9.1M | $19.0M |
| 15 | New Castle County Head Start INC | Unclassified | $8.2M | $2.1M |
| 16 | Delaware Technology Park INC | Community Improvement & Capacity Building | $7.2M | $55.9M |
| 17 | Aetna Hose Hook and Ladder Company of Newark Delaware | Health Care | $6.9M | $7.4M |
| 18 | Impact Life | Mental Health & Crisis Intervention | $6.8M | $5.2M |
| 19 | Little Sisters of the Poor INC | Housing & Shelter | $5.5M | $15.0M |
| 20 | Autism Delaware INC | Diseases, Disorders & Medical Disciplines | $5.4M | $7.1M |
| 21 | Delaware Special Olympics INC | Unclassified | $5.4M | $4.7M |
| 22 | Sonecha Family Foundation | Philanthropy, Voluntarism & Grantmaking | $5.0M | $13.4M |
| 23 | Newark Senior Center INC | Human Services | $4.2M | $9.7M |
| 24 | The Gromet Foundation | Education | $3.9M | $4.1M |
| 25 | International Literacy Association | Education | $3.9M | $4.7M |
| 26 | Delaware Academy of Medicine INC | Unclassified | $3.4M | $5.1M |
| 27 | Newark Country Club | Unclassified | $3.0M | $3.2M |
| 28 | American Philosophical Association INC | Health Care | $2.8M | $8.7M |
| 29 | Newark Day Nursery Assoc INC | Human Services | $2.5M | $3.2M |
| 30 | United Association of Journeymen & Apprentices of the Plumbing & Pipe | Unclassified | $2.4M | $10.8M |
| 31 | Parstem Realty Company INC | Unclassified | $2.3M | $4.6M |
| 32 | Delaware Insurance Guaranty Association | Unclassified | $2.1M | $27.4M |
| 33 | Laborers International Union of North America | Unclassified | $2.1M | $2.7M |
| 34 | Litow Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.0M | $6.6M |
| 35 | Tri-state Bird Rescue and Research INC | Animal-Related | $1.9M | $10.6M |
| 36 | Ctw Foundation INC | Unclassified | $1.8M | $11.1M |
| 37 | Delaware School Based Health Alliance INC | Health Care | $1.7M | $982K |
| 38 | Center for Growing Talent by Pma INC | Food, Agriculture & Nutrition | $1.5M | $1.6M |
| 39 | Islamic Acedamy of Delaware | Education | $1.5M | $1.7M |
| 40 | Scientific Committee on Oceanic Research | Science & Technology | $1.4M | $864K |
| 41 | Dfrc INC | Human Services | $1.4M | $1.6M |
| 42 | Sean Locke 24 Foundation | Youth Development | $1.4M | $1.9M |
| 43 | Endless Possibilities in the Community INC | Human Services | $1.3M | $136K |
| 44 | Quile Corporation | Unclassified | $1.2M | $0 |
| 45 | Plumbers & Pipefitters Local Union 74 Join Apprenticeship Com | Unclassified | $1.2M | $1.3M |
| 46 | Kind to Kids Foundation | Human Services | $1.2M | $2.5M |
| 47 | Delaware Saengerbund and Library Association | Arts, Culture & Humanities | $1.2M | $2.7M |
| 48 | Beats on the Streets INC | Public & Societal Benefit | $1.1M | $64K |
| 49 | Delaware Regional Dream Center INC | Religion-Related | $1.1M | $419K |
| 50 | Delaware Manufacturing Alliance INC | Unclassified | $1.1M | $1.3M |
| 51 | Organization of Pjm States INC | Science & Technology | $1.0M | $169K |
| 52 | Mark INC Ministries | Religion-Related | $1.0M | $1.1M |
| 53 | Delaware Contractors Association | Unclassified | $967K | $969K |
| 54 | Delaware Health Sciences Alliance LLC | Health Care | $959K | $4.7M |
| 55 | University of Delaware Research Foundation INC | Unclassified | $953K | $13.0M |
| 56 | Center for Accelerating Financial Equity INC | Community Improvement & Capacity Building | $910K | $841K |
| 57 | Hillel the Foundation for Jewish Campus Life | Unclassified | $892K | $3.5M |
| 58 | International Society of Political Psychology INC | Social Science | $842K | $3.6M |
| 59 | Newark Center for Creative Learning INC | Unclassified | $825K | $1.2M |
| 60 | Amalgamated Transit Union | Employment | $735K | $747K |
| 61 | Pet-assisted Visitation Volunteer Services INC | Human Services | $707K | $1.0M |
| 62 | John P and Ann Marie Martin Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $701K | $644K |
| 63 | Phi Beta Kappa Society | Unclassified | $695K | $1.1M |
| 64 | Water is Life Kenya INC | Unclassified | $694K | $389K |
| 65 | Kendal Aging | Housing & Shelter | $687K | $0 |
| 66 | ABC Parenting Institute | Human Services | $685K | $1.0M |
| 67 | Wisdom Dojo Incorporated | Human Services | $671K | $162K |
| 68 | Love& Hope Rescue Mission | Mental Health & Crisis Intervention | $654K | $89K |
| 69 | North East Association for Institutional Research | Medical Research | $637K | $480K |
| 70 | Women of Exception | Mental Health & Crisis Intervention | $608K | $308K |
| 71 | Girls on the Run Delaware INC | Youth Development | $608K | $1.1M |
| 72 | University Drama Group INC Chapel St. Players | Arts, Culture & Humanities | $594K | $817K |
| 73 | Perry Initiative | Education | $590K | $587K |
| 74 | Loris Hands INC | Human Services | $582K | $514K |
| 75 | Delaware Dance Cmpany | Arts, Culture & Humanities | $566K | $591K |
| 76 | Cumberland Valley Volunteer Firemens Association | Human Services | $532K | $544K |
| 77 | Improving Schools INC | Education | $464K | $18K |
| 78 | Caesar Rodney Institute | Public & Societal Benefit | $463K | $54K |
| 79 | Willa Road Childrens Center | Human Services | $458K | $2K |
| 80 | Friends of Cne INC | International, Foreign Affairs & National Security | $451K | $7K |
| 81 | Aaup-del Chapter | Unclassified | $433K | $1.0M |
| 82 | Joy Amisano Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $426K | $2.0M |
| 83 | Catholic Ministry to the Elderly | Human Services | $399K | $5.6M |
| 84 | Newark Area Welfare Committee INC | Unclassified | $395K | $186K |
| 85 | Paralyzed Veterans of America | Unclassified | $392K | $475K |
| 86 | Veterans Foreign Wars of US | Unclassified | $388K | $341K |
| 87 | Patent Information Users Group Incorporated | Community Improvement & Capacity Building | $383K | $284K |
| 88 | Renewed Life Christian Counseling Center INC | Human Services | $371K | $47K |
| 89 | Delaware Council on Economic Education INC | Social Science | $369K | $518K |
| 90 | Delaware Nurses Association | Unclassified | $340K | $331K |
| 91 | International Association for Vegetation Science INC | Environment | $334K | $704K |
| 92 | Gamma Phi Beta Sorority INC | Unclassified | $321K | $55K |
| 93 | Delaware Junior Blue Hens Ice Hockey Club | Recreation & Sports | $321K | $142K |
| 94 | American Federation of Labor & Congress of Industrial Orgs | Unclassified | $307K | $183K |
| 95 | Alsama Project INC | Human Services | $301K | $573K |
| 96 | Communication Workers of America | Unclassified | $298K | $188K |
| 97 | Head of Christiana Cemetery Association | Unclassified | $286K | $2.3M |
| 98 | National Humane Society | Animal-Related | $278K | $13K |
| 99 | Epilepsy Foundation of Delaware | Diseases, Disorders & Medical Disciplines | $272K | $489K |
| 100 | Premiere Charities INC | Food, Agriculture & Nutrition | $265K | $248K |