| 1 | Beebe Medical Center INC | Health Care | $644.7M | $723.8M |
| 2 | Beebe Physican Network INC | Health Care | $62.2M | $23.9M |
| 3 | Springpoint at Lewes INC | Housing & Shelter | $14.4M | $52.7M |
| 4 | Beebe Medical Foundation | Health Care | $13.2M | $41.6M |
| 5 | Luchen Foundation | Philanthropy, Voluntarism & Grantmaking | $8.8M | $14.0M |
| 6 | Lewes Fire Department Incorporated | Public Safety, Disaster Preparedness & Relief | $8.0M | $14.6M |
| 7 | Greater Lewes Foundation | Environment | $5.7M | $6.8M |
| 8 | Childrens Beach House INC | Unclassified | $5.2M | $17.2M |
| 9 | Lewes Yacht Club INC | Recreation & Sports | $3.7M | $12.3M |
| 10 | Masonic Hall Company Lewes | Unclassified | $2.9M | $4.2M |
| 11 | The Lewes Historical Society | Arts, Culture & Humanities | $2.6M | $6.0M |
| 12 | Motwani Jadeja Family Foundation | Philanthropy, Voluntarism & Grantmaking | $2.5M | $4.1M |
| 13 | Bdc Action Fund INC | Human Services | $2.5M | $637K |
| 14 | Meals on Wheels of Rehoboth and Lewes INC | Food, Agriculture & Nutrition | $1.8M | $1.8M |
| 15 | Captain Paul Watson Foundation | Science & Technology | $1.7M | $160K |
| 16 | Farr Family Foundation INC | Philanthropy, Voluntarism & Grantmaking | $1.6M | $3.6M |
| 17 | The Rosa Health Center INC | Health Care | $1.6M | $1.4M |
| 18 | Initiative for Medicines Access &knowledge I-mak INC | Crime & Legal-Related | $1.3M | $4.3M |
| 19 | Lewes Public Library INC | Education | $1.3M | $3.8M |
| 20 | Soldiers to Sidelines LLC | Human Services | $1.2M | $290K |
| 21 | Beta Foundation | Philanthropy, Voluntarism & Grantmaking | $1.2M | $7.1M |
| 22 | Lewes Senior Citizens Center INC | Human Services | $1.2M | $3.0M |
| 23 | Civic Influencers INC | Civil Rights, Social Action & Advocacy | $1.2M | $274K |
| 24 | Delaware Celebration of Jazz INC | Arts, Culture & Humanities | $1.1M | $759K |
| 25 | Wildmon INC | Animal-Related | $950K | $101K |
| 26 | US Lng Association | Community Improvement & Capacity Building | $950K | $191K |
| 27 | More Foundation Group | Human Services | $801K | $523K |
| 28 | Lewes Rehoboth Lodge No 646 Loyal Order of Moose INC | Mutual & Membership Benefit | $733K | $730K |
| 29 | Alec Baker Sullivan Foundation INC | Philanthropy, Voluntarism & Grantmaking | $707K | $850K |
| 30 | Sussex Preparatory Academy Foundation | Education | $684K | $25.6M |
| 31 | Paul Kares INC | Unclassified | $666K | $24K |
| 32 | What is Your Voice INC | Mental Health & Crisis Intervention | $645K | $1.5M |
| 33 | Exponent Group INC | Religion-Related | $615K | $128K |
| 34 | Global Echo Litigation Center INC | International, Foreign Affairs & National Security | $534K | $104K |
| 35 | Conversation Agreement Fund a Nj Nonprofit Corporation | Environment | $523K | $838K |
| 36 | American Legion | Unclassified | $503K | $469K |
| 37 | Havanese Rescue INC | Animal-Related | $485K | $1.9M |
| 38 | High Impact Athletes | Philanthropy, Voluntarism & Grantmaking | $480K | $181K |
| 39 | Road Runners Club of America | Unclassified | $460K | $54K |
| 40 | Greater Lewes Community Village | Human Services | $407K | $692K |
| 41 | Bagel Bombers Baseball Association | Recreation & Sports | $405K | $99K |
| 42 | Denizens Society Global | Public Safety, Disaster Preparedness & Relief | $403K | $142K |
| 43 | Nodehealth Foundation | Health Care | $398K | $214K |
| 44 | Gender Equality Network USA INC | Civil Rights, Social Action & Advocacy | $330K | $240K |
| 45 | Sunshine Approach Foundation Company INC | International, Foreign Affairs & National Security | $323K | $625K |
| 46 | Spritely Networked Communities Institute | Science & Technology | $291K | $245K |
| 47 | Build a Dream Family Foundation | Philanthropy, Voluntarism & Grantmaking | $289K | $532K |
| 48 | History Book Festival at Lewes INC | Arts, Culture & Humanities | $279K | $42K |
| 49 | U S Sections of the Combustion Institute | Science & Technology | $278K | $257K |
| 50 | Family Promise of Southern Delaware INC | Human Services | $275K | $282K |
| 51 | Rosenberger Family Charitable Trust | Unclassified | $270K | $920K |
| 52 | Lewes Chamber of Commerce INC | Community Improvement & Capacity Building | $262K | $277K |
| 53 | Lewes in Bloom INC | Environment | $262K | $376K |
| 54 | Thriving in Games Group INC | Social Science | $251K | $201K |
| 55 | Bethel Methodist Cemetery INC | Mutual & Membership Benefit | $249K | $1.7M |
| 56 | Task Force Butler Institute | Public & Societal Benefit | $249K | $11K |
| 57 | Fort Miles Museum and Historical Area INC | Arts, Culture & Humanities | $236K | $221K |
| 58 | Psymposia INC | Arts, Culture & Humanities | $236K | $89K |
| 59 | Overfalls Maritime Museum Foundation | Arts, Culture & Humanities | $228K | $2.1M |
| 60 | Marine Education Research and Rehabilitation Institute INC | Animal-Related | $226K | $486K |
| 61 | Veterinary Pharmacology Research Foundation | Animal-Related | $217K | $337K |
| 62 | Friends of Potentino INC | International, Foreign Affairs & National Security | $206K | $4K |
| 63 | We Re Listening INC | Arts, Culture & Humanities | $204K | $54K |
| 64 | True Blue Jazz INC | Arts, Culture & Humanities | $199K | $3K |
| 65 | Cape Henlopen Educational Foundation | Education | $196K | $374K |
| 66 | Fort Miles Historical Association INC | Arts, Culture & Humanities | $192K | $723K |
| 67 | Sussex Rotary Can-do Playground INC | Recreation & Sports | $186K | $180K |
| 68 | Coastal Concerts INC | Arts, Culture & Humanities | $175K | $207K |
| 69 | Awesome Treasures Foundation | International, Foreign Affairs & National Security | $172K | $10K |
| 70 | Brandywine Pastoral Institute INC | Unclassified | $155K | $66K |
| 71 | Beebe Medical Center Auxiliary INC | Health Care | $151K | $126K |
| 72 | Southern Delaware Alliance for Racial Justice | Civil Rights, Social Action & Advocacy | $146K | $149K |
| 73 | Richwood Pre School Incorporated | Education | $144K | $61K |
| 74 | Little League Baseball INC | Unclassified | $137K | $290K |
| 75 | Lewes Lions Foundation | Human Services | $132K | $1 |
| 76 | Blue Heron Agility Dogs of Delaware | Animal-Related | $131K | $95K |
| 77 | Friends of the Lewes Public Library INC | Unclassified | $128K | $212K |
| 78 | Parkinsons Education & Support Group of Sussex County | Diseases, Disorders & Medical Disciplines | $127K | $184K |
| 79 | Rotary International | Unclassified | $127K | $128K |
| 80 | Vets 1ST INC | Recreation & Sports | $126K | $939K |
| 81 | Delaware River and Bay Lighthouse Foundation INC | Environment | $112K | $629K |
| 82 | Engaged Health Foundation | Health Care | $105K | $320 |
| 83 | Unique Minds Changing Lives INC | Human Services | $100K | $10K |
| 84 | Creative Coastal Connections Corp. | Philanthropy, Voluntarism & Grantmaking | $100K | $11K |
| 85 | Toller Rescue INC | Animal-Related | $96K | $11K |
| 86 | Lewes Elementary PTO Association | Education | $96K | $40K |
| 87 | Kids Paradise Foundation INC | International, Foreign Affairs & National Security | $95K | $90K |
| 88 | U S China Health Products Association | Human Services | $91K | $125K |
| 89 | Oaxaca Christian School INC | Education | $88K | $133K |
| 90 | Lewes Unleashed Association | Animal-Related | $83K | $266K |
| 91 | Bright Hope Foundation | Religion-Related | $81K | $81K |
| 92 | Delaware Shore Field Hockey INC | Recreation & Sports | $78K | $15K |
| 93 | Miriams Table | Education | $77K | $53K |
| 94 | Irish American University INC | Education | $74K | $1.5M |
| 95 | Simon and Ann Chen Foundation | Philanthropy, Voluntarism & Grantmaking | $71K | $348K |
| 96 | Save Groundwater Foundation | Environment | $63K | $53K |
| 97 | Eastern States Section of the Combustion Institute | Science & Technology | $60K | $147K |
| 98 | Loma Linda Publishing Company | Arts, Culture & Humanities | $60K | $131K |
| 99 | Giving Hope Network | Philanthropy, Voluntarism & Grantmaking | $50K | $84K |
| 100 | Lewes Junction Railroad and Bridge Association INC | Arts, Culture & Humanities | $49K | $273K |