| 1 | Childrens Hospital of Orange County | Health Care | $1.5B | $2.2B |
| 2 | Chapman University | Education | $1.2B | $2.3B |
| 3 | St. Joseph Hospital of Orange | Health Care | $971.1M | $939.4M |
| 4 | Center for Comprehensive Care and Diagnosis of Inherited Blood | Health Care | $133.7M | $71.3M |
| 5 | Childrens Hospital at Mission | Health Care | $103.8M | $80.2M |
| 6 | Airconditioning and Refrigeration Industry Health and Welfare Trust | Unclassified | $77.0M | $79.5M |
| 7 | Choc Foundation | Health Care | $71.1M | $137.0M |
| 8 | The Sharon D Lund Foundation | Unclassified | $51.3M | $137.3M |
| 9 | Childrens Healthcare of California | Health Care | $39.0M | $0 |
| 10 | Open Doors International INC | Unclassified | $30.2M | $17.3M |
| 11 | Lutheran Social Services of Southern California | Philanthropy, Voluntarism & Grantmaking | $21.7M | $25.8M |
| 12 | Boy Scouts of America | Unclassified | $18.9M | $43.1M |
| 13 | Santiago Middle School | Education | $17.9M | $10.1M |
| 14 | S L Gimbel Foundation | Philanthropy, Voluntarism & Grantmaking | $16.7M | $332.7M |
| 15 | Project Access INC | Community Improvement & Capacity Building | $16.2M | $4.2M |
| 16 | Coalition of Orange County Community Clinics | Health Care | $14.1M | $44.1M |
| 17 | International Brotherhood of Electrical Workers | Unclassified | $13.7M | $11.2M |
| 18 | Swenson Family Foundation | Unclassified | $13.3M | $97.1M |
| 19 | Crc Real Estate Corporation | Health Care | $13.2M | $87.1M |
| 20 | Orange Housing Development Corporation | Unclassified | $13.0M | $80.6M |
| 21 | Orange County Classical Academy | Education | $12.4M | $11.2M |
| 22 | Shah Happiness Foundation | Philanthropy, Voluntarism & Grantmaking | $11.0M | $9.3M |
| 23 | Providence Speech & Hearing Center | Health Care | $10.8M | $12.9M |
| 24 | William & Margaret Fern Holmes Family Foundation | Philanthropy, Voluntarism & Grantmaking | $9.2M | $30.5M |
| 25 | General Truck Drivers Office Food and Warehouse Local 952 | Unclassified | $8.4M | $1.8M |
| 26 | Casa Teresa INC | Human Services | $8.1M | $6.9M |
| 27 | Western Wall and Ceiling Contractors Association INC | Unclassified | $8.0M | $17.5M |
| 28 | Sisters of St. Joseph Healthcare Foundation | Health Care | $7.4M | $52.2M |
| 29 | Court Appointed Special Advocates of Orange County INC | Civil Rights, Social Action & Advocacy | $6.4M | $12.9M |
| 30 | St. Jeanne de Lestonnac Free Clinic | Unclassified | $6.4M | $11.1M |
| 31 | Grandmas House of Hope | Housing & Shelter | $5.1M | $5.0M |
| 32 | Global Gifted Foundation | Medical Research | $4.7M | $8.9M |
| 33 | Southern California Contractors Association INC | Unclassified | $4.1M | $4.0M |
| 34 | Trent Elijah Foundation | Religion-Related | $4.1M | $5.3M |
| 35 | Neighborhood Housing Services of Orange County INC | Community Improvement & Capacity Building | $3.9M | $37.2M |
| 36 | Bayan | Education | $3.9M | $2.3M |
| 37 | Breath of the Spirit Ministries International INC | Religion-Related | $3.7M | $192K |
| 38 | The Hub Oc | Human Services | $3.6M | $1.8M |
| 39 | Carver Family Future Generation Foundation | Philanthropy, Voluntarism & Grantmaking | $3.5M | $7.7M |
| 40 | Stanley W Ekstrom Foundation INC | Philanthropy, Voluntarism & Grantmaking | $3.4M | $56.4M |
| 41 | Willow International | Human Services | $3.4M | $1.1M |
| 42 | M Zamin & Reshma Farukhi Family Foundation | Philanthropy, Voluntarism & Grantmaking | $3.3M | $1.5M |
| 43 | Healthy Relationships California | Human Services | $3.3M | $386K |
| 44 | The Sheepfold | Unclassified | $3.2M | $8.3M |
| 45 | Mariposa Women and Family Center | Mental Health & Crisis Intervention | $3.2M | $3.2M |
| 46 | Orange Elderly Services INC | Human Services | $3.0M | $2.7M |
| 47 | Friendly Center INC | Unclassified | $2.9M | $3.5M |
| 48 | Destination Science Education for Every Child | Recreation & Sports | $2.9M | $1.2M |
| 49 | United Association of Journeymen & Apprentices of the Plumbing & Pipe | Unclassified | $2.8M | $6.3M |
| 50 | Shepherd Academics INC | Education | $2.7M | $200K |
| 51 | Miller Foundation | Human Services | $2.7M | $966K |
| 52 | International School of Orange County | Education | $2.6M | $1.0M |
| 53 | Marys Kitchen | Food, Agriculture & Nutrition | $2.6M | $3.1M |
| 54 | Orthopaedic Education and Research | Medical Research | $2.5M | $962K |
| 55 | Global Equity Organization | Human Services | $2.0M | $1.7M |
| 56 | Mission Plasticos | Health Care | $1.8M | $2.3M |
| 57 | Jordan Motor Car Company Museum | Arts, Culture & Humanities | $1.7M | $1.5M |
| 58 | National Electrical Contractors Association | Unclassified | $1.5M | $8.4M |
| 59 | Advantage Foster Family Agency | Human Services | $1.5M | $486K |
| 60 | Orange County Dental Society Suite 450 | Unclassified | $1.5M | $2.8M |
| 61 | Coast Soccer League INC | Recreation & Sports | $1.4M | $2.6M |
| 62 | American Federation of Labor & Congress of Industrial Orgs | Unclassified | $1.4M | $1.4M |
| 63 | Westpark Las Palmas Homeowners Association | Community Improvement & Capacity Building | $1.4M | $2.9M |
| 64 | United Union of Roofers Waterproofers & Allied Workers | Unclassified | $1.3M | $2.7M |
| 65 | Assistance League of Orange Calif INC | Human Services | $1.2M | $2.1M |
| 66 | Santiago Canyon College Foundation | Education | $1.2M | $2.4M |
| 67 | Bidada International Foundation | Health Care | $1.2M | $264K |
| 68 | Occa Foundation | Education | $1.2M | $176K |
| 69 | Resource Oversight & Guidance Services INC | Human Services | $1.1M | $649K |
| 70 | Orange Rotary Community Trust Fund | Unclassified | $1.1M | $837K |
| 71 | Islamic Shura Council of Southern California | Religion-Related | $1.1M | $1.8M |
| 72 | A Quarter Blue | Crime & Legal-Related | $1.1M | $345K |
| 73 | Family Support Network | Unclassified | $1.0M | $821K |
| 74 | Benevolent & Protective Order of Elks of the USA | Unclassified | $1.0M | $644K |
| 75 | Southern California Union Roofers Labor-management Trust | Employment | $986K | $3.9M |
| 76 | Airforwarders Association | Unclassified | $906K | $1.1M |
| 77 | L-arche Wavecrest | Human Services | $880K | $1.1M |
| 78 | Free & Accepted Masons of California | Unclassified | $852K | $1.2M |
| 79 | Hernandez Mariachi Heritage Society | Unclassified | $834K | $359K |
| 80 | Youth Centers of Orange INC | Youth Development | $827K | $6K |
| 81 | Building Owners & Managers Association of Orange County INC | Unclassified | $825K | $218K |
| 82 | Corey and Leslie Leyton Family Foundation | Philanthropy, Voluntarism & Grantmaking | $815K | $444K |
| 83 | Underground Grit INC | Mental Health & Crisis Intervention | $795K | $119K |
| 84 | Marathon Cooperative INC | Housing & Shelter | $783K | $3.7M |
| 85 | Communication Workers of America | Unclassified | $771K | $1.0M |
| 86 | Adelphia Classical Christian Academy | Education | $768K | $941K |
| 87 | Union Roofing Contractorsassociation | Community Improvement & Capacity Building | $766K | $3.2M |
| 88 | Marina L Schreyer Charitable Tr | Philanthropy, Voluntarism & Grantmaking | $745K | $6.2M |
| 89 | Josue Yrion World Evangelism and Missions INC | Religion-Related | $743K | $3.3M |
| 90 | Living Well Pregnancy Centers | Health Care | $733K | $874K |
| 91 | Orange County Association of Health Underwriters | Unclassified | $708K | $468K |
| 92 | The Community Foundation of Orange | Philanthropy, Voluntarism & Grantmaking | $688K | $1.1M |
| 93 | Orange Junior Soccer Club | Recreation & Sports | $612K | $123K |
| 94 | Freedom Movement INC | Crime & Legal-Related | $611K | $236K |
| 95 | Orange Schools Financing Corporation | Unclassified | $607K | $8.8M |
| 96 | Pediatrics-adolescent Diabetes Research and Education Foundation | Medical Research | $605K | $612K |
| 97 | Masonic Temple Association of Orange California | Unclassified | $598K | $1.7M |
| 98 | Manara West | Education | $587K | $492K |
| 99 | Medical Staff of Saint Joseph Hospital of Orange | Health Care | $580K | $2.2M |
| 100 | Ousd School Pride INC | Education | $570K | $59K |