| 1 | Helix Charter High School | Education | $43.2M | $23.2M |
| 2 | Bona Fide Conglomerate INC | Employment | $7.9M | $2.2M |
| 3 | Clinton and Lucille McKinnon Christian Foundation | Philanthropy, Voluntarism & Grantmaking | $7.7M | $7.7M |
| 4 | Child Nutrition Program of Southern California INC | Food, Agriculture & Nutrition | $6.2M | $1.3M |
| 5 | National University Academy Sparrow | Education | $4.7M | $983K |
| 6 | The Thomas C Ackerman Foundation | Unclassified | $4.7M | $4.0M |
| 7 | Military Outreach Mission - San Diego | Public & Societal Benefit | $4.3M | $162K |
| 8 | Oasis Institute | Human Services | $3.9M | $1.9M |
| 9 | International Brotherhood of Teamsters | Employment | $3.2M | $5.8M |
| 10 | Free Flow Soccer Club | Youth Development | $2.1M | $538K |
| 11 | Animal Pad | Animal-Related | $2.0M | $2.0M |
| 12 | Sheet Metal & Air Conditioning Contractor Assoc of San Diego | Unclassified | $1.8M | $808K |
| 13 | Community Action Service & Advocacy | Unclassified | $1.5M | $1.2M |
| 14 | Sheet Metal & Air Conditioning Contractors of San Diego Industry | Unclassified | $1.4M | $104K |
| 15 | Elizabeth N Crane Foundation | Philanthropy, Voluntarism & Grantmaking | $1.4M | $6.6M |
| 16 | Emmanuel Family Homes INC | Human Services | $1.3M | $482K |
| 17 | Association of Environmental Professional INC | Unclassified | $1.2M | $1.4M |
| 18 | Pacific Southwest Railway Museum | Arts, Culture & Humanities | $1.1M | $4.4M |
| 19 | Therapy Center INC | Unclassified | $988K | $826K |
| 20 | The Howard G and Samita B Jacobs | Philanthropy, Voluntarism & Grantmaking | $848K | $2.8M |
| 21 | Anchor Down Owners Association INC | Housing & Shelter | $567K | $3.6M |
| 22 | San Diego Hockey Referee Association a California Nonprofit | Recreation & Sports | $532K | $57K |
| 23 | 17170 Bernardo Center LLC | Education | $527K | $7.7M |
| 24 | Mt Helix Park Foundation | Philanthropy, Voluntarism & Grantmaking | $508K | $3.3M |
| 25 | Kind Hearts San Diego | Human Services | $495K | $35K |
| 26 | Hope for Iraqi Christians | Religion-Related | $472K | $522K |
| 27 | Curley Foundation | Philanthropy, Voluntarism & Grantmaking | $446K | $1.0M |
| 28 | Stepping Higher INC | Education | $396K | $56K |
| 29 | Margaret R Seeley Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $393K | $285K |
| 30 | San Diego East County Aquatics | Recreation & Sports | $366K | $104K |
| 31 | Friends of International Friendship Park INC | Recreation & Sports | $350K | $136K |
| 32 | Bridge Christian Academy INC | Education | $345K | $88K |
| 33 | American Legion | Unclassified | $335K | $36K |
| 34 | Brauner Family Foundation | Human Services | $331K | $996K |
| 35 | Brady Family Foundation | Unclassified | $318K | $835K |
| 36 | La Mesa Village Association | Community Improvement & Capacity Building | $309K | $300K |
| 37 | Port of San Diego Ship Repair Association | Community Improvement & Capacity Building | $303K | $163K |
| 38 | La Mesa Park and Recreation Foundation | Recreation & Sports | $300K | $843K |
| 39 | San Diego California Soccer League | Recreation & Sports | $283K | $278K |
| 40 | Project Bluewater Racing | Unclassified | $275K | $706K |
| 41 | First Responder Whiskey Society | International, Foreign Affairs & National Security | $261K | $27K |
| 42 | California Teachers Association | Unclassified | $240K | $470K |
| 43 | Crosspointe Life Holdings Corporation INC | Religion-Related | $235K | $630K |
| 44 | Partners Therapeutic Horsemanship INC | Human Services | $230K | $185K |
| 45 | Alliance of Arts and Athletics | Arts, Culture & Humanities | $211K | $563K |
| 46 | La Mesa First United Methodist Foundation | Unclassified | $205K | $822K |
| 47 | Well INC | Religion-Related | $201K | $90K |
| 48 | Vietnam Reform Foundation | Philanthropy, Voluntarism & Grantmaking | $200K | $585K |
| 49 | San Diego Emergency Medical Services Association | Employment | $197K | $161K |
| 50 | La Mesa Police Officers Assn INC | Unclassified | $192K | $242K |
| 51 | California Teachers Association | Unclassified | $189K | $352K |
| 52 | International Society of Computed Tomography | Health Care | $174K | $239K |
| 53 | Cajon Valley Education Association | Unclassified | $169K | $174K |
| 54 | La Mesa Chamber of Commerce INC | Community Improvement & Capacity Building | $158K | $64K |
| 55 | La Mesa Arts Foundation INC | Education | $156K | $117K |
| 56 | Action Sports Outreach | Religion-Related | $152K | $66K |
| 57 | Mybalto Foundation | Animal-Related | $151K | $97K |
| 58 | Mary & Yelda Attisha Foundation INC | Human Services | $147K | $17K |
| 59 | Little League Baseball INC | Unclassified | $145K | $126K |
| 60 | PTA California Congress of Parents Teachers & Students INC | Unclassified | $142K | $164K |
| 61 | Little League Baseball INC | Recreation & Sports | $139K | $43K |
| 62 | Your Safe Place Foundation | Crime & Legal-Related | $137K | $226K |
| 63 | He Lives Ministries | Unclassified | $136K | $8K |
| 64 | Mantle of Praise Ministries Incorporated | Unclassified | $135K | $51K |
| 65 | Rally4reilly & Friends | Diseases, Disorders & Medical Disciplines | $130K | $25K |
| 66 | Survivors of Suicide-san Diego | Mental Health & Crisis Intervention | $130K | $136K |
| 67 | New Day Womens Center INC | Mental Health & Crisis Intervention | $129K | $9K |
| 68 | PTA California Congress of Parents Teachers & Students INC | Unclassified | $126K | $81K |
| 69 | California Teachers Association | Unclassified | $125K | $544K |
| 70 | Helix Instrumental Music Association | Unclassified | $124K | $74K |
| 71 | Helix High School Foundation | Education | $119K | $191K |
| 72 | Mission Made Simple | Education | $118K | $36K |
| 73 | Wilderness Institute | Environment | $115K | $138K |
| 74 | United States Bowling Congress INC | Recreation & Sports | $114K | $71K |
| 75 | La Mesa Firefighters Local 4759 | Employment | $105K | $26K |
| 76 | Project Compassion INC | International, Foreign Affairs & National Security | $105K | $174K |
| 77 | La Mesa Community Welfare Association INC | Unclassified | $105K | $367K |
| 78 | International Alliance Theatrical Stage Employees & Moving Picture | Unclassified | $99K | $267K |
| 79 | Horseless Carriage Foundation INC | Unclassified | $98K | $981K |
| 80 | Nancy Neffson and Wetmore Family Foundation | Philanthropy, Voluntarism & Grantmaking | $97K | $10.3M |
| 81 | Global Community College Leadership Network INC | Education | $96K | $439K |
| 82 | Hoi Den Hung Foundation | Arts, Culture & Humanities | $90K | $268K |
| 83 | Christian Mission to Israel INC | Religion-Related | $87K | $754K |
| 84 | PTA California Congress of Parents Teachers & Students INC | Unclassified | $86K | $32K |
| 85 | PTA California Congress of Parents Teachers & Students INC | Unclassified | $82K | $89K |
| 86 | 3-H Foundation | Education | $76K | $1.4M |
| 87 | East County Media | Arts, Culture & Humanities | $72K | $82K |
| 88 | Grand Prix Region Porsche Club Ofamerica | Recreation & Sports | $72K | $89K |
| 89 | Pinto Junior Foundation | Philanthropy, Voluntarism & Grantmaking | $65K | $65K |
| 90 | PTA California Congress of Parents Teachers & Students INC | Unclassified | $65K | $37K |
| 91 | PTA California Congress of Parents Teachers & Students INC | Unclassified | $65K | $15K |
| 92 | La Mesa Womans Club Foundation | Community Improvement & Capacity Building | $59K | $1.8M |
| 93 | House of Restoration INC | Education | $53K | $139 |
| 94 | Soroptimist International of the Americas INC | Crime & Legal-Related | $53K | $57K |
| 95 | Fadeaways and Fundamentals | Unclassified | $48K | $8K |
| 96 | Gateway to Growth | Human Services | $47K | $24K |
| 97 | PTA California Congress of Parents Teachers & Students INC | Unclassified | $46K | $10K |
| 98 | Lord of the Harvest Ministries INC | Religion-Related | $45K | $47K |
| 99 | PTA California Congress of Parents Teachers & Students INC | Unclassified | $42K | $15K |
| 100 | Rotary Club of Lamesa California Foundation Incorporated | Philanthropy, Voluntarism & Grantmaking | $39K | $363K |