| 1 | St. Joseph Health Northern California LLC | Health Care | $1.5B | $1.2B |
| 2 | Easter Seals Southern California INC | Unclassified | $535.7M | $220.4M |
| 3 | Sequoia Climate Foundation | Philanthropy, Voluntarism & Grantmaking | $367.7M | $113.7M |
| 4 | Arnold and Mabel Beckman Foundation | Philanthropy, Voluntarism & Grantmaking | $316.0M | $720.9M |
| 5 | United Agricultural Association Emp Welfare Bene Pl Tr | Unclassified | $263.3M | $105.4M |
| 6 | Orange County Community Foundation | Philanthropy, Voluntarism & Grantmaking | $239.7M | $688.2M |
| 7 | University of California Irvine Foundation | Education | $217.5M | $1.0B |
| 8 | Western Growers Assurance Trust | Unclassified | $197.1M | $137.6M |
| 9 | Mind Oc | Human Services | $141.6M | $198.1M |
| 10 | Concordia University | Education | $134.6M | $254.2M |
| 11 | Edwards Lifesciences Foundation | Philanthropy, Voluntarism & Grantmaking | $112.3M | $81.4M |
| 12 | Second Harvest Food Bank of Orange County INC | Food, Agriculture & Nutrition | $94.6M | $36.4M |
| 13 | Rivian Foundation | Environment | $87.6M | $662.4M |
| 14 | Jewish Community Foundation of Orange County | Philanthropy, Voluntarism & Grantmaking | $69.4M | $124.4M |
| 15 | Quality Development and Construction INC | Housing & Shelter | $63.4M | $19.9M |
| 16 | Taco Bell Foundation INC | Unclassified | $60.7M | $82.3M |
| 17 | Tiger Woods Charity Event Corp. | Philanthropy, Voluntarism & Grantmaking | $56.2M | $27.5M |
| 18 | Tiger Woods Foundation INC | Education | $54.0M | $147.1M |
| 19 | Capital Group Companies Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $52.7M | $415.4M |
| 20 | The Jatain Foundation | Unclassified | $49.9M | $75.3M |
| 21 | Sun Family Foundation | Philanthropy, Voluntarism & Grantmaking | $46.2M | $91.8M |
| 22 | Jamboree Housing Corporation | Unclassified | $45.7M | $340.3M |
| 23 | Tarbut Vtorah Community Day School | Education | $36.3M | $112.9M |
| 24 | Ladera Ranch Maintenance Corporation | Community Improvement & Capacity Building | $33.3M | $21.3M |
| 25 | Waymakers | Crime & Legal-Related | $32.6M | $13.2M |
| 26 | Pacific Symphony | Arts, Culture & Humanities | $32.2M | $60.5M |
| 27 | Mind Education | Science & Technology | $31.5M | $37.1M |
| 28 | Orange Countys United Way | Philanthropy, Voluntarism & Grantmaking | $28.3M | $33.6M |
| 29 | Caritas Corporation | Housing & Shelter | $28.2M | $201.2M |
| 30 | Mamba and Mambacita Sports Foundation | Human Services | $28.2M | $49.3M |
| 31 | William S and Nancy E Thompson Foundation | Philanthropy, Voluntarism & Grantmaking | $26.6M | $79.1M |
| 32 | Western Growers Assn. | Unclassified | $25.0M | $92.4M |
| 33 | Excel Academy Charter Schools | Education | $22.8M | $12.5M |
| 34 | St. Joseph Health System Foundation | Health Care | $22.3M | $132.3M |
| 35 | Rinks Foundation | Recreation & Sports | $22.3M | $25.9M |
| 36 | Irvine Ice Foundation | Recreation & Sports | $22.0M | $105.2M |
| 37 | Association for Specialty Coffee | Unclassified | $21.4M | $28.6M |
| 38 | Jewish Community Center of Orange County | Human Services | $21.4M | $44.7M |
| 39 | Orange County Music and Dance INC | Arts, Culture & Humanities | $20.3M | $30.9M |
| 40 | Rancho Mission Viejo Master Maintenance Corporation | Housing & Shelter | $20.0M | $13.9M |
| 41 | Flying Leatherneck Historical Foundation | Arts, Culture & Humanities | $20.0M | $17.1M |
| 42 | The Roberto Foundation | Education | $19.9M | $73.7M |
| 43 | Free Wheelchair Mission | Health Care | $19.5M | $4.9M |
| 44 | Big West Conference | Unclassified | $18.8M | $11.7M |
| 45 | USA Water Polo INC | Recreation & Sports | $18.6M | $9.2M |
| 46 | Child Care Providers United - California Workers Health Care Fun | Health Care | $18.3M | $92.9M |
| 47 | In-n-out Burgers Foundation | Philanthropy, Voluntarism & Grantmaking | $17.9M | $45.6M |
| 48 | Irvine Campus Housing Authority | Housing & Shelter | $17.5M | $118.5M |
| 49 | Girl Scouts of Orange County | Youth Development | $17.0M | $37.3M |
| 50 | Bardeen Partners INC | Unclassified | $16.7M | $279.1M |
| 51 | Slave 2 Nothing Foundation | Philanthropy, Voluntarism & Grantmaking | $16.7M | $28.6M |
| 52 | Caritas Affordable Housing INC | Housing & Shelter | $16.3M | $99.7M |
| 53 | Treasure Foundation | Philanthropy, Voluntarism & Grantmaking | $16.1M | $34.0M |
| 54 | Woodbridge Village Association | Unclassified | $15.3M | $50.1M |
| 55 | Layne Foundation a Corp. | Unclassified | $15.2M | $61.1M |
| 56 | Rancho Santa Margarita Landscape & Recrdation Corporation | Unclassified | $13.6M | $13.3M |
| 57 | Warne Family Charitable Foundation | Philanthropy, Voluntarism & Grantmaking | $13.6M | $26.6M |
| 58 | Families Forward | Unclassified | $13.0M | $32.4M |
| 59 | New Horizon Educational Foundation | Education | $12.6M | $38.2M |
| 60 | California Health Medical Reserve Corps | Community Improvement & Capacity Building | $12.3M | $6.8M |
| 61 | Los Angeles Chapter National Tooling & Machine Assn Training Ce | Unclassified | $11.7M | $7.3M |
| 62 | Irvine Ranch Conservancy | Environment | $11.7M | $7.0M |
| 63 | Aids Services Foundation Orange County | Unclassified | $11.4M | $3.3M |
| 64 | McBeth Foundation Trust 021290 | Unclassified | $11.2M | $16.8M |
| 65 | Irvine Ranch Water District Water Service Corporation | Unclassified | $11.2M | $10.5M |
| 66 | Council on Aging-southern California INC | Human Services | $11.1M | $5.5M |
| 67 | Bluebird Legacy INC | Philanthropy, Voluntarism & Grantmaking | $10.8M | $41.0M |
| 68 | New Horizon School Irvine | Education | $10.7M | $2.7M |
| 69 | Southern California Volleyball Association | Recreation & Sports | $10.5M | $4.0M |
| 70 | I-rise Foundation | Philanthropy, Voluntarism & Grantmaking | $10.2M | $9.1M |
| 71 | Housing with Heart INC | Human Services | $9.4M | $3.3M |
| 72 | E&s Wung Foundation | Philanthropy, Voluntarism & Grantmaking | $9.4M | $1.1M |
| 73 | Friends of the Girl Scouts Trust | Youth Development | $9.0M | $21.5M |
| 74 | Motorcycle Safety Foundation INC | Unclassified | $8.8M | $6.5M |
| 75 | Natural Communities Coalition | Environment | $8.7M | $32.3M |
| 76 | Building Industry Association of Southern California INC | Unclassified | $8.7M | $4.7M |
| 77 | Irvine Public Schools Foundation | Philanthropy, Voluntarism & Grantmaking | $8.3M | $9.4M |
| 78 | Boys & Girls Clubs of Central Orange Coast | Unclassified | $8.3M | $12.4M |
| 79 | South Coast Charter School Association | Education | $8.1M | $2.9M |
| 80 | Irvine Barclay Theatre Operating Co | Arts, Culture & Humanities | $8.1M | $7.1M |
| 81 | Hoag Charity Sports | Health Care | $8.0M | $6.2M |
| 82 | Alzheimers Orange County | Diseases, Disorders & Medical Disciplines | $7.9M | $5.8M |
| 83 | Arthritis National Research Foundation | Medical Research | $7.7M | $10.2M |
| 84 | South County Outreach | Unclassified | $7.6M | $5.4M |
| 85 | Gsf Foundation | Philanthropy, Voluntarism & Grantmaking | $7.5M | $19.8M |
| 86 | Miracles for Kids INC | Recreation & Sports | $7.4M | $12.9M |
| 87 | Motorcycle Industry Council INC | Unclassified | $7.1M | $9.6M |
| 88 | Teach a Man to Fish Foundation | Philanthropy, Voluntarism & Grantmaking | $6.9M | $144.4M |
| 89 | Preserve Master Maintenance Corporation | Human Services | $6.9M | $10.0M |
| 90 | South Coast Chinese Cultural Asso | Arts, Culture & Humanities | $6.9M | $18.2M |
| 91 | 9 11 Day | Philanthropy, Voluntarism & Grantmaking | $6.9M | $819K |
| 92 | Newport Coast Community Association | Housing & Shelter | $6.8M | $10.0M |
| 93 | Human Options INC | Human Services | $6.7M | $12.7M |
| 94 | The Reed J Levecke Foundation | Unclassified | $6.5M | $13.8M |
| 95 | Western Mandarin Immersion Charter School | Education | $6.1M | $996K |
| 96 | Waltmar Foundation | Unclassified | $6.1M | $10.2M |
| 97 | Del Sur Community Association | Housing & Shelter | $6.0M | $10.0M |
| 98 | Philharmonic Society of Orange County | Arts, Culture & Humanities | $5.8M | $4.8M |
| 99 | Irvine Onnuri Church | Religion-Related | $5.8M | $8.9M |
| 100 | Mind Research Institute INC | Science & Technology | $5.7M | $2.9M |