| 1 | UPMC Pittsburgh | $25.7B | $24.3B | $11.2B |
| 2 | Highmark Health Pittsburgh | $6.4B | $6.1B | $4.5B |
| 3 | Geisinger Health Plan Danville | $3.2B | $3.2B | $1.1B |
| 4 | Carnegie Mellon University Pittsburgh | $3.1B | $2.0B | $7.2B |
| 5 | Health Partners Plans INC Philadelphia | $2.6B | $2.6B | $724.5M |
| 6 | American Electric Power System Employees Benefit Tr Pittsburgh | $2.4B | $336.6M | $14.0M |
| 7 | National Elevator Industry Health Benefit Plan Newtown Sq | $2.4B | $1.2B | $3.4B |
| 8 | Pennsylvania Employees Benefit Harrisburg | $1.6B | $1.3B | $1.2B |
| 9 | United Steelworkers Pittsburgh | $1.6B | $694.0M | $2.1B |
| 10 | Albert Einstein Healthcare Network Philadelphia | $1.5B | $1.5B | $1.6B |
| 11 | Gbu Financial Life Pittsburgh | $1.4B | $1.0B | $4.7B |
| 12 | William Penn Foundation Philadelphia | $1.2B | $0 | $3.4B |
| 13 | United States Steel Corporation Represented Retirees Benefit Trust Pittsburgh | $955.7M | $45.5M | $1.6B |
| 14 | Steelworkers Health & Welfare Fund Pittsburgh | $922.8M | $909.0M | $110.2M |
| 15 | St. Lukes Physician Group INC Bethlehem | $865.6M | $865.6M | $120.0M |
| 16 | Pew Memorial Trust Philadelphia | $668.2M | $563.7M | $4.3B |
| 17 | Excela Health Greensburg | $603.0M | $598.4M | $717.7M |
| 18 | St. Clair Health Corporation Pittsburgh | $586.9M | $506.7M | $814.5M |
| 19 | National Slovak Society of the USA Canonsburg | $483.8M | $325.2M | $1.8B |
| 20 | Allegheny County Schools Health Insurance Consortium Wexford | $459.8M | $459.8M | $150.7M |
| 21 | Welfare Benefits Funding Plan for Employees of Temple University Philadelphia | $426.4M | $47.3M | $389.2M |
| 22 | Childrens Health Care Associates INC Philadelphia | $417.6M | $412.9M | $246.8M |
| 23 | Constellation Peco Retiree Medical Trust Kennett Square | $412.7M | $12.1M | $97.2M |
| 24 | Entergy Corp Companies Bargaining Employees Welfare Benefit Trust Pittsburgh | $402.6M | $95.3M | $442.2M |
| 25 | Constellation Employees Benefit Trust for Management Employees Kennett Square | $396.1M | $11.1M | $52.1M |
| 26 | Laborers District Council of Pittsburgh | $384.1M | $123.3M | $532.7M |
| 27 | Eastern Atlantic States Carpenters Health Fund Philadelphia | $345.2M | $332.9M | $997.0M |
| 28 | Vizo Financial Corporate Credit Union Middletown | $342.7M | $342.7M | $6.0B |
| 29 | Phi Group Return Dillsburg | $308.0M | $278.6M | $873.3M |
| 30 | Enbridge Employee Services INC Welfare Benefit Plans Trust Pittsburgh | $304.0M | $119.5M | $168.1M |
| 31 | Pennsylvania Life and Health Insurance Guaranty Association Bala Cynwyd | $283.0M | $250.6M | $245.0M |
| 32 | Hillman Family Foundations Pittsburgh | $258.3M | $0 | $1.9B |
| 33 | Pnc Foundation Pittsburgh | $257.2M | $0 | $166.0M |
| 34 | Oberkotter Foundation Philadelphia | $237.2M | $0 | $213.8M |
| 35 | Main Line Services Radnor | $234.4M | $234.4M | $33.0M |
| 36 | Pennsylvania Property and Casualty Insurance Guaranty Association Philadelphia | $230.7M | $19.8M | $186.6M |
| 37 | Central Pennsylvania Teamsters Health and Welfare Fund Wyomissing | $217.8M | $131.6M | $193.5M |
| 38 | Tower Health Medical Group West Reading | $217.7M | $217.6M | $42.3M |
| 39 | Trumark Financial Credit Union Ft Washington | $214.9M | $198.1M | $3.4B |
| 40 | Iupat District Council 21 Welfare Fund Philadelphia | $213.8M | $100.4M | $93.2M |
| 41 | Lincoln Benefit Trust New Oxford | $205.6M | $205.6M | $87.6M |
| 42 | Steamfitters Local Union 420 Welfare Fund Philadelphia | $204.9M | $102.9M | $235.3M |
| 43 | United Brotherhood of Carpenters and Joiners of America Pittsburgh | $204.3M | $137.2M | $480.7M |
| 44 | District Council 33 Health-welfare Philadelphia | $195.9M | $195.9M | $180.3M |
| 45 | Operating Engineers Welfare Fund of Eastern Pa & Delaware Ft Washington | $195.2M | $96.7M | $243.1M |
| 46 | Sarah Scaife Foundation INC Pittsburgh | $187.2M | $0 | $588.2M |
| 47 | Moravian University Bethlehem | $160.3M | $140.6M | $375.7M |
| 48 | Law Enforcement Health Benefits INC Philadelphia | $158.0M | $146.0M | $102.2M |
| 49 | Point Park University Pittsburgh | $151.1M | $131.3M | $197.6M |
| 50 | Zachary Smith Reynolds Trust Pittsburgh | $150.0M | $0 | $205.1M |