| 1 | Southwest Research Institute San Antonio | $927.2M | $926.4M | $1.1B |
| 2 | Blueforge Alliance Bryan | $480.9M | $480.9M | $74.6M |
| 3 | Society of Petroleum Engineers Spe INC Richardson | $43.9M | $41.2M | $48.4M |
| 4 | Botanical Research Institute of Texas INC Fort Worth | $22.8M | $22.3M | $21.8M |
| 5 | Fajr Scientific Houston | $18.3M | $18.2M | $6.6M |
| 6 | Institute for Creation Research Dallas | $11.4M | $10.4M | $53.5M |
| 7 | Numfocus INC Austin | $8.4M | $8.4M | $6.4M |
| 8 | Houston Advanced Research Center Spring | $7.8M | $7.8M | $6.8M |
| 9 | Brink Technology INC Austin | $6.9M | $6.7M | $13.7M |
| 10 | Palacios Marine Agricultural Research INC Corpus Christi | $5.7M | $3.2M | $4.3M |
| 11 | Free Code Camp INC Plano | $3.0M | $3.0M | $9.8M |
| 12 | Texas Energy Poverty Research Institute Austin | $1.9M | $1.9M | $1.9M |
| 13 | Edge Institute INC Austin | $1.8M | $1.8M | $989K |
| 14 | Responsible Artificial Intelligence Institute Austin | $1.7M | $1.7M | $253K |
| 15 | Organic Syntheses INC Wayne State University Waco | $1.7M | $0 | $13.5M |
| 16 | Women in Bio INC Dallas | $1.6M | $1.6M | $1.2M |
| 17 | Geeks Without Frontiers Austin | $1.5M | $1.5M | $226K |
| 18 | Texas Biomedical Forum San Antonio | $1.4M | $1.0M | $50K |
| 19 | Science Teachers Association of Texas Austin | $1.4M | $1.4M | $639K |
| 20 | Alek Kavcic Foundation Austin | $1.3M | $0 | $693K |
| 21 | The Center for the Research of Early Christian Documents Plano | $1.1M | $1.0M | $507K |
| 22 | Dallas Makerspace Carrollton | $1.0M | $963K | $835K |
| 23 | Three Rivers Foundation for the Arts and Sciences INC Crowell | $1.0M | $0 | $222K |
| 24 | American Society of Civil Engineers Austin | $848K | $848K | $996K |
| 25 | Southwestern Petroleum Short Course Association INC Lubbock | $773K | $773K | $1.0M |
| 26 | Alliance for Pathways into Engineer Ing Austin | $607K | $606K | $488K |
| 27 | NASA Hunch Foundation Webster | $600K | $600K | $579K |
| 28 | American Society of Parasitologists INC a New Mexico Nonprofit Corpo Huntsville | $499K | $400K | $1.5M |
| 29 | At Conference International Pearland | $494K | $494K | $173K |
| 30 | Houston Gas Processors Association Houston | $481K | $309K | $386K |
| 31 | Center for Maximum Potential Building Systems INC Austin | $480K | $480K | $1.0M |
| 32 | Ietf Intellectual Property Management Corporation Mesquite | $423K | $423K | $341K |
| 33 | Public Invention Austin | $407K | $407K | $265K |
| 34 | Geophysical Society of Houston Houston | $406K | $406K | $789K |
| 35 | Austin Science Education Foundation Austin | $388K | $382K | $311K |
| 36 | High-tech High Heels Dallas | $351K | $326K | $969K |
| 37 | Houston Hispanic Architects & Engineers Society INC Houston | $308K | $174K | $285K |
| 38 | Renewable Energy Alliance - Houston INC Houston | $307K | $307K | $309K |
| 39 | Youth Code Jam San Antonio San Antonio | $301K | $301K | $340K |
| 40 | Shaibani Family Foundation Houston | $300K | $300K | $300K |
| 41 | Dallas Alliance of Technology & Women Irving | $296K | $296K | $353K |
| 42 | Association of Space Explorers USA Webster | $288K | $288K | $551K |
| 43 | Research Theory INC Austin | $282K | $282K | $73K |
| 44 | San Antonio Community Resource Directory San Antonio | $279K | $279K | $62K |
| 45 | Lamar Research Foundation Beaumont | $274K | $274K | $259K |
| 46 | Black Girls Do Engineer Corporation Webster | $272K | $272K | $32K |
| 47 | Institute for Leadership in Capital Projects Seguin | $267K | $267K | $72K |
| 48 | National Space Grant Alliance INC Austin | $246K | $246K | $652K |
| 49 | Information Systems Security Association Lewisville | $223K | $223K | $70K |
| 50 | International Behavioral Neuroscience Society Bandera | $214K | $214K | $441K |