| 1 | Advanced Technology International Summerville | $4.8B | $4.8B | $2.2B |
| 2 | Medical Technology Enterprise Consortium Summerville | $234.5M | $234.5M | $89.2M |
| 3 | National Council of Examiners for Engineering and Surveying Greenville | $79.2M | $45.7M | $107.9M |
| 4 | South Carolina Research Authority Columbia | $16.2M | $16.2M | $101.5M |
| 5 | One Nation Innovation Columbia | $13.0M | $13.0M | $2.2M |
| 6 | Ncees Foundation Greenville | $10.7M | $3.2M | $11.8M |
| 7 | Sc Thrive Columbia | $10.2M | $8.1M | $9.6M |
| 8 | University Industry Demonstration Partnership INC Columbia | $4.2M | $4.2M | $2.1M |
| 9 | International Mechanical Diagnosis and Therapy Research Foundation Blythewood | $643K | $43K | $430K |
| 10 | Palmetto Innosphere INC Piedmont | $335K | $335K | $15K |
| 11 | World of Euc Mt Pleasant | $240K | $240K | $33K |
| 12 | Charleston Center for Paleontology Charleston | $221K | $221K | $92K |
| 13 | South Carolina Engineering Conference Columbia | $99K | $99K | $28K |
| 14 | National Science and Engineering Alliance INC Lake City | $98K | $98K | $27K |
| 15 | Cdc Education Foundation Charleston | $92K | $92K | $109K |
| 16 | Vc Expeditions Charleston | $85K | $85K | $16K |
| 17 | South Coast Cyber Center INC Beaufort | $83K | $83K | $128K |
| 18 | American Chemical Society Aiken | $63K | $63K | $431K |
| 19 | Innovision Awards Organization Greenville | $62K | $62K | $1K |
| 20 | Archeological Institute of the Pee Dee Florence | $58K | $58K | $50K |
| 21 | Sc Division of the International Association for Identification Charleston | $17K | $17K | $33K |
| 22 | Richard T Greener Institute for Social Policy Columbia | $8K | $0 | $2 |
| 23 | Engineering Leadership Daniel Island | $1 | $0 | $1K |
| 24 | Association for Computing Machinery Spartanburg | $0 | $0 | $0 |
| 25 | Scbio Foundation Greenville | $0 | $0 | $39K |
| 26 | Building Enclosure Council -charleston Summerville | $0 | $0 | $0 |
| 27 | Southeastern Universities Nuclear Reactors Institute for Science and Aiken | $0 | $0 | $0 |
| 28 | Eastern Section of the Sepm Society for Sedimentary Geology Charleston | $0 | $0 | $0 |
| 29 | Savannah River Section of the Amer Nuclear Society Incorporated Term Aiken | $0 | $0 | $0 |
| 30 | Technology Research Services Columbia | $0 | $0 | $0 |
| 31 | South Carolina Archaeology Public Outreach Division INC Columbia | $0 | $0 | $0 |
| 32 | Space Debris Foundation Columbia | $0 | $0 | $0 |
| 33 | Wikiciv Org INC Greenville | $0 | $0 | $0 |
| 34 | Upstate South Carolina General Mobile Radio Service Group INC Pickens | $0 | $0 | $0 |
| 35 | North Carolina Quantum Association Columbia | $0 | $0 | $0 |
| 36 | Gaming for Hope INC Conway | $0 | $0 | $0 |
| 37 | Center of Excellence for Research and Program Innovation Denmark | $0 | $0 | $0 |
| 38 | Lewis Ai & Data Science Center INC Charleston | $0 | $0 | $0 |
| 39 | Comprehensive Community Based Solutions INC Rock Hill | $0 | $0 | $0 |
| 40 | Ascue INC Conway | $0 | $0 | $0 |
| 41 | Symposium on Stimuli-responsive Materials Clemson | $0 | $0 | $0 |
| 42 | National Society of Black Engineers N Charleston | $0 | $0 | $0 |
| 43 | Isc2 Charleston Chapter Daniel Island | $0 | $0 | $0 |
| 44 | National Society of Black Engineers Columbia | $0 | $0 | $0 |
| 45 | South Carolina Society of Nuclear Medicine Chapin | $0 | $0 | $0 |
| 46 | Cola Makerspace Columbia | $0 | $0 | $0 |
| 47 | South Carolina Entomological Society Columbia | $0 | $0 | $0 |
| 48 | Midlands Astronomy Club INC Columbia | $0 | $0 | $0 |
| 49 | Lowcountry Stargazers Charleston | $0 | $0 | $0 |
| 50 | Lowcountry Institute for Future Technologies INC Sheldon | $0 | $0 | $0 |