| 1 | Research Triangle Institute Durham | $1.5B | $1.4B | $935.9M |
| 2 | McNc Research Triangle Park | $74.2M | $74.1M | $175.1M |
| 3 | McNc Endowment Research Triangle Park | $57.6M | $6.1M | $168.5M |
| 4 | International Society of Automation Durham | $28.3M | $17.2M | $50.5M |
| 5 | North Carolina Biotechnology Center Durham | $23.3M | $23.1M | $44.0M |
| 6 | Isothermal Planning and Development Corporation Rutherfordton | $14.6M | $14.6M | $5.6M |
| 7 | International Union of Pure and Applied Chemistry Durham | $4.8M | $2.6M | $7.5M |
| 8 | Wireless Research Center of North Carolina Wake Forest | $3.7M | $3.7M | $731K |
| 9 | The Rna Society Raleigh | $3.6M | $2.0M | $3.8M |
| 10 | Real Estate Standards Organization Raleigh | $3.3M | $3.3M | $3.4M |
| 11 | Nc Idea Durham | $2.3M | $0 | $51.5M |
| 12 | Muddy Sneakers INC Raleigh | $1.5M | $1.5M | $1.8M |
| 13 | Arborcrest Gardens INC Boone | $934K | $0 | $3.4M |
| 14 | Education and Research Consortium of Western North Carolina Asheville | $892K | -$211K | $12.9M |
| 15 | Pisgah Astronomical Research Institute Rosman | $731K | $728K | $17.6M |
| 16 | Institute of Digital Engineering USA Mooresville | $727K | $727K | $1.1M |
| 17 | North Carolina Center for Automotive Research INC Garysburg | $716K | $716K | $7.8M |
| 18 | Rci-iibec Foundation INC Raleigh | $478K | $408K | $725K |
| 19 | Hubzone Technology Initiative INC Henderson | $429K | $429K | $139K |
| 20 | Ech Institute INC Cary | $423K | $423K | $425K |
| 21 | Live Learn Innovate Foundation Raleigh | $337K | $337K | $138K |
| 22 | Mathematical Metaphysics Institute Sanford | $276K | $276K | $36K |
| 23 | Cape Fear Bird Observatory INC Wilmington | $252K | $252K | $51K |
| 24 | Plastic Ocean Project INC Wilmington | $238K | $238K | $191K |
| 25 | Port Discover Northeastern North Carolinas Center for Hands on Scie Elizabeth Cty | $221K | $218K | $444K |
| 26 | Lake Norman It Professionals Cornelius | $209K | $102K | $147K |
| 27 | Bent Creek Institute INC Asheville | $152K | $151K | $193K |
| 28 | Its Carolinas INC Raleigh | $149K | $149K | $52K |
| 29 | Feilding Foundation Raleigh | $146K | $0 | $101K |
| 30 | Southeastern Residency Conference INC Wallace | $134K | $134K | $52K |
| 31 | Generational Radiation Impact Project INC Candler | $118K | $118K | $121K |
| 32 | Symbioseas Carolina Bch | $102K | $102K | $27K |
| 33 | Society for Acupuncture Research INC Winston Salem | $96K | $94K | $56K |
| 34 | Automotive Security Research Group Southport | $81K | $0 | $16K |
| 35 | North Carolina Arcgis Users Group INC Raleigh | $81K | $81K | $31K |
| 36 | Group for the Research of Intelligent Agent Networked Techno Mars Hill | $77K | $77K | $1 |
| 37 | Triangle Biotech Tuesday Durham | $75K | $75K | $53K |
| 38 | Western North Carolina Human Resources Association Asheville | $64K | $64K | $144K |
| 39 | Nc Stem Academy Cary | $47K | $47K | $924 |
| 40 | History of Earth Sciences Society Boone | $37K | $37K | $126K |
| 41 | B-sides Rdu Cary | $36K | $0 | $8K |
| 42 | International Technology Center Rtp | $34K | $34K | $276K |
| 43 | Foundation for Shackleford Horses INC Beaufort | $23K | $23K | $29K |
| 44 | Black Butterfly Org INC Wilmington | $21K | $21K | $11K |
| 45 | Neuroscience Group Chapel Hill | $19K | $19K | $15K |
| 46 | Innovateconnect INC Holly Springs | $18K | $0 | $8K |
| 47 | Blue Ridge Ruby Candler | $18K | $0 | $2K |
| 48 | Dnn Association INC Raleigh | $16K | $16K | $69K |
| 49 | Institute for Patient-centered Design INC Winterville | $12K | $12K | $14K |
| 50 | Family Business Ethics Institute INC Cornelius | $10K | $10K | $3K |