| 1 | Christian Healthcare Ministries INC Barberton | $754.7M | $754.7M | $292.8M |
| 2 | Trihealth INC Cincinnati | $390.9M | $354.3M | $2.4B |
| 3 | Upward Bound Youth Wooster | $225.1M | $222.2M | $206.7M |
| 4 | Christian Aid Ministries Berlin | $170.1M | $168.7M | $123.4M |
| 5 | Gospel Light Mennonite Church Medical Aid Plan INC Canton | $165.1M | $163.4M | $29.7M |
| 6 | Bon Secours Mercy Health Foundation Blue Ash | $90.5M | $87.0M | $436.9M |
| 7 | Foundation of the Catholic Diocese of Columbus Columbus | $51.1M | $21.2M | $289.0M |
| 8 | United States Catholic Conference Cleveland | $42.3M | $4.3M | $89.6M |
| 9 | Dynamic Catholic Institute Cincinnati | $40.0M | $27.5M | $47.9M |
| 10 | United States Catholic Conference Cleveland | $40.0M | $4.1M | $85.9M |
| 11 | Cpps Heritage Mission Fund Dayton | $30.6M | $7.0M | $26.3M |
| 12 | Truth for Life Solon | $29.6M | $24.0M | $34.7M |
| 13 | Jewish Family Service Association of Cleveland Ohio Pepper Pike | $28.0M | $28.0M | $64.5M |
| 14 | United States Catholic Conference Cleveland | $25.8M | $3.0M | $54.9M |
| 15 | Shalom Ministries International INC Dublin | $22.0M | $22.0M | $29.9M |
| 16 | Weiss Family Private Operating Foundation Cleveland | $16.5M | $0 | $41.5M |
| 17 | Back 2 Back Ministries INC Mason | $16.4M | $13.9M | $17.0M |
| 18 | Lutheran Home Westlake | $14.2M | $14.1M | $22.0M |
| 19 | Cleveland Christian Home INC Cleveland | $14.1M | $14.1M | $15.2M |
| 20 | Scepter Publishers Strongsville | $13.5M | $3.2M | $7.1M |
| 21 | Lutheran Metropolitan Ministry Cleveland | $13.4M | $13.1M | $22.2M |
| 22 | Jewish Education Center of Cleveland Cleveland Hts | $13.2M | $13.2M | $19.3M |
| 23 | Keycorp Empl Beneficiary Assoc Tr for Post-retirement Medical Bene Brooklyn | $12.5M | $3.0M | $26.7M |
| 24 | Cise Cincinnati | $11.8M | $6.0M | $12.4M |
| 25 | St. Paul Center for Biblical Theology Steubenville | $11.3M | $10.9M | $21.0M |
| 26 | Lifestone Ministries INC Middlebrg Hts | $11.1M | $9.1M | $19.0M |
| 27 | Christian Aid Ministries Foundation Berlin | $11.0M | $7.6M | $25.2M |
| 28 | Sisters of Charity of St. Augustine Health System INC Cleveland | $10.5M | $1.2M | $23.8M |
| 29 | Independent Baptist Mission for Asians INC Marietta | $9.9M | $9.9M | $2.5M |
| 30 | Premier Health Partners Dayton | $9.4M | $4.4M | $80.8M |
| 31 | Futurechurch Cleveland | $9.2M | $858K | $1.1M |
| 32 | Youngstown Area Jewish Foundation Youngstown | $9.1M | $3.6M | $52.8M |
| 33 | Hugo Goldsmith Trust 22224400 Cincinnati | $8.9M | $0 | $7.1M |
| 34 | Building Hope in the City Cleveland | $7.6M | $5.2M | $8.3M |
| 35 | Jewish Community of Canton LLC Canton | $7.5M | $7.2M | $7.0M |
| 36 | Gross Schechter Day School Pepper Pike | $5.7M | $5.6M | $7.4M |
| 37 | Bloc Ministries INC Cincinnati | $5.6M | $5.3M | $10.4M |
| 38 | Well-being Foundation of Pickaway County Circleville | $5.3M | $1.4M | $6.5M |
| 39 | First Baptist Church Scripture Publishing Ministery INC Milford | $5.3M | $5.3M | $6.7M |
| 40 | New Destiny Treatment Center INC Clinton | $5.2M | $5.2M | $8.1M |
| 41 | Jewish Columbus Columbus | $5.1M | $5.1M | $1.6M |
| 42 | Geauga Amish Loan Fund Burton | $5.0M | $0 | $108.5M |
| 43 | Found House-interfaith Housing Network Cincinnati | $4.7M | $4.7M | $2.5M |
| 44 | O S U Chabad House INC New Albany | $4.6M | $4.6M | $10.2M |
| 45 | Do Good in His Name INC Osgood | $4.5M | $4.5M | $9.2M |
| 46 | Community Development for All People Columbus | $4.2M | $4.2M | $6.9M |
| 47 | The Foundation of the Islamic Center of Greater Toledo INC Perrysburg | $4.2M | $1.2M | $3.3M |
| 48 | Refuge INC Columbus | $4.2M | $4.1M | $4.4M |
| 49 | Camp Carl Ltd Ravenna | $4.1M | $4.1M | $2.3M |
| 50 | Crane Family Foundation Columbus | $4.1M | $1.0M | $25.7M |