| 1 | Michael & Susan Dell Foundation Austin | $6.6B | $0 | $7.8B |
| 2 | Stephens Greth Family Foundation INC Midland | $2.0B | $0 | $2.0B |
| 3 | Moody Foundation Galveston | $1.5B | $0 | $3.5B |
| 4 | Stoller Foundation Houston | $1.5B | $0 | $1.1B |
| 5 | The Dallas Foundation Dallas | $677.2M | $160.0M | $491.5M |
| 6 | Laura and John Arnold Foundation Houston | $621.7M | $0 | $4.8B |
| 7 | Greater Houston Community Foundation Houston | $567.5M | $293.3M | $1.1B |
| 8 | Sarofim Foundation Houston | $567.2M | $0 | $2.6B |
| 9 | Meadows Foundation Incorporated Dallas | $443.1M | $0 | $718.0M |
| 10 | Houston Endowment INC Houston | $427.4M | $0 | $2.5B |
| 11 | San Antonio Area Foundation San Antonio | $308.1M | $108.0M | $640.7M |
| 12 | Charitable Assets Tr Austin | $281.6M | $274.5M | $205.5M |
| 13 | Health Foundation of East Texas Tyler | $268.6M | $0 | $173.0M |
| 14 | Brown Foundation INC Houston | $261.0M | $0 | $1.1B |
| 15 | Communities Foundation of Texas Dallas | $244.5M | $249.3M | $1.0B |
| 16 | Carl and Marilynn Thoma Dallas | $243.0M | $0 | $1.2B |
| 17 | Rainwater Charitable Foundation Fort Worth | $201.1M | $0 | $931.4M |
| 18 | Austin Community Foundation Austin | $191.4M | $79.3M | $556.3M |
| 19 | Community Foundation of North Texas Fort Worth | $189.4M | $96.4M | $544.9M |
| 20 | Nelda C and Hj Lutcher Stark Foundation Orange | $187.5M | $0 | $419.2M |
| 21 | Fmh Foundation Midland | $182.2M | $0 | $537.3M |
| 22 | Musk Foundation Austin | $168.2M | $0 | $463.0M |
| 23 | Methodist Primary Care Group Houston | $144.2M | $144.2M | $51.5M |
| 24 | Karakin Foundation Abilene | $143.0M | $0 | $193.7M |
| 25 | Harvey E Najim Charitable Foundation San Antonio | $140.6M | $0 | $113.4M |
| 26 | Laurie and Reed Morian Foundation Houston | $140.4M | $0 | $152.4M |
| 27 | Kinder Foundation Houston | $118.5M | $0 | $173.4M |
| 28 | Heavenly Fathers Foundation Cisco | $117.6M | $0 | $228.1M |
| 29 | Dian Graves Owen Foundation Abilene | $111.7M | $0 | $194.8M |
| 30 | Mulva Family Foundation Austin | $108.7M | $0 | $540.6M |
| 31 | Permian Basin Area Foundation Midland | $107.9M | $43.7M | $331.0M |
| 32 | Scharbauer Foundation INC Midland | $102.4M | $0 | $560.0M |
| 33 | William a Brookshire Foundation Lakeway | $101.3M | $0 | $192.3M |
| 34 | Scott & White Healthcare Dallas | $100.9M | $15.9M | $1.3B |
| 35 | J E and L E Mabee Foundation INC Midland | $100.3M | $0 | $798.9M |
| 36 | Hildebrand Foundation Houston | $98.8M | $0 | $130.4M |
| 37 | A Legacy Foundation Southlake | $98.2M | $0 | $11.8M |
| 38 | John and Susan Wilder Foundation Dallas | $93.5M | $0 | $54.6M |
| 39 | Jack R Macdonald Charitable Trust Dallas | $93.2M | $18.0M | $191.5M |
| 40 | Stanley E Fulton Family Foundation Dallas | $93.1M | $0 | $208.2M |
| 41 | Robert a Welch Foundation 062491 Houston | $92.9M | $0 | $619.0M |
| 42 | James N McCoy Foundation Wichita Falls | $92.5M | $0 | $227.5M |
| 43 | Knapp Community Care Foundation INC Weslaco | $91.2M | $0 | $124.9M |
| 44 | United Way of Greater Houston Houston | $88.4M | $79.6M | $99.5M |
| 45 | Barbara Kauffman Welder Private Foundation Victoria | $87.9M | $0 | $124.3M |
| 46 | Impetus Foundation San Antonio | $86.2M | $0 | $274.9M |
| 47 | Houston Jewish Community Foundation Houston | $85.9M | $33.4M | $260.7M |
| 48 | Warren Charitable Foundation Midland | $83.2M | $0 | $158.4M |
| 49 | Dan L Duncan Family Foundation Houston | $81.0M | $0 | $700.5M |
| 50 | Luke and Lori Morrow Family Foundation McKinney | $79.2M | $0 | $87.2M |