| 1 | Signatry Charitable Trust Sioux Falls | $1.4B | $1.0B | $816.2M |
| 2 | Sanford Health Foundation Sioux Falls | $474.3M | $214.4M | $1.3B |
| 3 | Margot and Tom Pritzker Foundation Sioux Falls | $423.8M | $423.3M | $449.6M |
| 4 | Sioux Falls Area Community Foundation INC Sioux Falls | $152.8M | $106.8M | $364.5M |
| 5 | South Dakota Community Foundation Pierre | $60.9M | $60.1M | $939.2M |
| 6 | Black Hills Area Community Foundation Rapid City | $32.8M | $13.9M | $66.9M |
| 7 | Seeds of Change Foundation Sioux Falls | $29.6M | $0 | $10.7M |
| 8 | Oahe Foundation Pierre | $20.6M | $6.6M | $25.8M |
| 9 | Robert and Rita Elmen Foundation Sioux Falls | $20.0M | $0 | $86.4M |
| 10 | John T Vucurevich Foundation Rapid City | $18.5M | $0 | $152.0M |
| 11 | Watertown Community Foundation Watertown | $14.9M | $4.6M | $944K |
| 12 | Branches Foundation Sioux Falls | $13.2M | $0 | $29.0M |
| 13 | Frank W Veden Charitable Tr Ua 35412910 Sioux Falls | $10.0M | $0 | $12.9M |
| 14 | Vc Medical Endowment Tr Sioux Falls | $8.0M | $1.1M | $20.2M |
| 15 | Esther and Harold Mertz Foundation Sioux Falls | $7.4M | $0 | $665.6M |
| 16 | Denny Sanford Foundation Sioux Falls | $7.3M | $0 | $28.1M |
| 17 | Milo Stip Charitable Remainder Unitrust Sioux Falls | $7.2M | $0 | $38.5M |
| 18 | H and M Kellogg Charitable Trust 35417890 Sioux Falls | $6.5M | $0 | $7.6M |
| 19 | Comfort Family Foundation Sioux Falls | $6.4M | $0 | $9.6M |
| 20 | Pontius Family Foundation Dtd 022597 Sioux Falls | $6.3M | $0 | $4.2M |
| 21 | The Aditi Foundation Sioux Falls | $5.6M | $0 | $4.3M |
| 22 | John D & Edna a Hofer Tr Mitchell | $5.3M | $0 | $19.8M |
| 23 | Houston Family Foundation Sioux Falls | $5.2M | $0 | $58.0M |
| 24 | Rh Growth Foundation Sioux Falls | $5.1M | $0 | $1.5M |
| 25 | Eleanors Fund Newell | $5.0M | $0 | $5.1M |
| 26 | Raft Charitable Foundation Sioux Falls | $4.9M | $0 | $22.6M |
| 27 | Orrion and Edith Barger Memorial Foundation INC Chamberlain | $4.5M | $0 | $9.1M |
| 28 | Cassini Tr Sioux Falls | $4.3M | $0 | $8.0M |
| 29 | Walter and Virginia Hager Foundation Mobridge | $4.0M | $0 | $4.1M |
| 30 | Blythe Brenden-mann Foundation Sioux Falls | $3.9M | $0 | $22.2M |
| 31 | United Way of the Black Hills Rapid City | $3.3M | $2.3M | $9.2M |
| 32 | Bob & Eileen Gilman Family Foundation Sioux Falls | $3.0M | $0 | $2.7M |
| 33 | Brenden Mann Foundation Sioux Falls | $2.8M | $0 | $18.3M |
| 34 | Marion Bradley via Memorial Foundation South Dakota Sioux Falls | $2.6M | $0 | $7.5M |
| 35 | James and Eloise Elmen Foundation Sioux Falls | $2.5M | $0 | $10.7M |
| 36 | Childrens Museum of South Dakota Brookings | $2.4M | $0 | $6.8M |
| 37 | Oyate Teca Project Kyle | $2.2M | $2.2M | $1.5M |
| 38 | Engelsma Family Foundation Sioux Falls | $2.1M | $0 | $5.6M |
| 39 | The Mike Cindy and Kylie Huether Family Foundation Sioux Falls | $1.8M | $0 | $4.8M |
| 40 | Ruth a and Raymond a Reister Charitable Trust Sioux Falls | $1.8M | $0 | $8.4M |
| 41 | Nehring Family Nice Foundation Sioux Falls | $1.7M | $0 | $5.2M |
| 42 | Brass Family Foundation Lennox | $1.7M | $0 | $2.3M |
| 43 | Scottish Rite Foundation of South Dakota Mitchell | $1.6M | $1.0M | $4.1M |
| 44 | Black Hills Corporation Foundation Rapid City | $1.6M | $0 | $5.5M |
| 45 | Aspen Trust Rapid City | $1.4M | $0 | $7.5M |
| 46 | Carol Clarkson Eklund Foundation Belle Fourche | $1.2M | $0 | $4.5M |
| 47 | Thomas and Julianne Youngren Foundation Sioux Falls | $1.2M | $0 | $4.9M |
| 48 | Joseph Raunhorst Family Foundation Sioux Falls | $1.1M | $0 | $9.3M |
| 49 | Edwards Family Foundation Aberdeen | $1.1M | $0 | $4.6M |
| 50 | Mitchell Area Charitable Foundation Mitchell | $1.1M | $233K | $3.2M |