| 1 | National Philanthropic Tr Jenkintown | $15.9B | $15.9B | $42.2B |
| 2 | Vanguard Charitable Endowment Program Malvern | $12.4B | $6.4B | $22.2B |
| 3 | John Templeton Foundation West Conshohocken | $2.7B | $0 | $3.6B |
| 4 | Glaxosmithkline Patient Access Programs Foundation Philadelphia | $1.1B | $0 | $85.3M |
| 5 | Richard King Mellon Foundation Dtd 01-01-47 Ligonier | $623.2M | $0 | $2.7B |
| 6 | The Pittsburgh Foundation Pittsburgh | $464.6M | $159.1M | $1.5B |
| 7 | Longwood Gardens INC Kennett Sq | $312.1M | $0 | $1.5B |
| 8 | Cahouet Foundation Pittsburgh | $294.5M | $0 | $257.2M |
| 9 | Dietrich Foundation Pittsburgh | $187.3M | $107.3M | $1.5B |
| 10 | Erie Community Foundation Erie | $154.2M | $39.8M | $385.7M |
| 11 | J Howard Pew Freedom Tr Philadelphia | $137.7M | $116.6M | $884.5M |
| 12 | Philadelphia Foundation Philadelphia | $131.5M | $88.9M | $704.6M |
| 13 | Colcom Foundation Pittsburgh | $127.5M | $0 | $450.8M |
| 14 | High Foundation Lancaster | $122.6M | $0 | $241.9M |
| 15 | York County Community Foundation York | $112.9M | $19.5M | $224.5M |
| 16 | Donald B and Dorothy L Stabler Foundation Camp Hill | $110.4M | $0 | $24.0M |
| 17 | Jewish Federation of Greater Pittsburgh Pittsburgh | $109.0M | $47.8M | $352.3M |
| 18 | Passavant Hospital Foundation Pittsburgh | $105.9M | $7.9M | $57.1M |
| 19 | Jewish Federation of Greater Philadelphia Philadelphia | $96.7M | $73.0M | $476.4M |
| 20 | Lor Foundation INC West Chester | $93.9M | $0 | $323.4M |
| 21 | Karabots Foundation Ft Washington | $88.4M | $0 | $90.5M |
| 22 | I Am Mercy Foundation Haverford | $88.0M | $0 | $411.2M |
| 23 | J E Barbey 8 Tenacre Foundation Pittsburgh | $84.6M | $0 | $62.8M |
| 24 | Hamilton Family Charitable Trust Wayne | $84.3M | $0 | $232.1M |
| 25 | The Comcast Nbcuniversal Foundation Philadelphia | $80.7M | $0 | $22.8M |
| 26 | Lehigh Valley Community Foundation Allentown | $73.6M | $16.8M | $84.6M |
| 27 | Wyncote Foundation Philadelphia | $72.6M | $0 | $604.9M |
| 28 | The James Family Charitable Trust Jenkintown | $70.8M | $70.8M | $402.1M |
| 29 | Alcoa Foundation Pittsburgh | $68.9M | $0 | $150.3M |
| 30 | Chubb Charitable Foundation Philadelphia | $67.6M | $0 | $74.9M |
| 31 | Andrea W and Kenneth C Frazier Family Foundation Newtown | $65.0M | $0 | $65.7M |
| 32 | Arconic Foundation Pittsburgh | $64.8M | $0 | $181.0M |
| 33 | Greenberg Foundation Equinunk | $62.8M | $0 | $114.4M |
| 34 | Helena Devereux Foundation Villanova | $60.3M | $14.6M | $196.1M |
| 35 | Clark Assoc Charitable Foundation Lancaster | $58.2M | $0 | $51.3M |
| 36 | Anabaptist Foundation Lewisburg | $57.6M | $49.6M | $81.8M |
| 37 | The American Electric Power System Retiree Medical Benefit Trust for Pittsburgh | $57.1M | $41.1M | $521.0M |
| 38 | The M S Hershey Foundation Hershey | $56.5M | $25.7M | $73.1M |
| 39 | The United Way of Southwestern Pennsylvania Pittsburgh | $55.4M | $38.5M | $92.4M |
| 40 | Fund for Charitable Giving Pittsburgh | $55.0M | $55.0M | $155.1M |
| 41 | Feeding Pennsylvania Lemoyne | $54.7M | $25.0M | $21.9M |
| 42 | Five Together Foundation Tr Philadelphia | $52.1M | $0 | $43.0M |
| 43 | United Way of Greater Philadelphia and Southern New Jersey Philadeplhia | $51.9M | $27.0M | $113.9M |
| 44 | Lancaster County Community Foundation Lancaster | $51.7M | $24.0M | $184.6M |
| 45 | Community Foundation of Western Pennsylvania and Eastern Ohio Sharon | $50.1M | $27.7M | $153.0M |
| 46 | Cornell Medical Benefits Tr Pittsburgh | $47.9M | $13.3M | $389.8M |
| 47 | Howmet Aerospace Foundation Pittsburgh | $42.9M | $0 | $141.5M |
| 48 | Daniel B and Florence E Green Foundation Conshohocken | $41.3M | $0 | $198.9M |
| 49 | N2 Stone Foundation Wallingford | $40.7M | $0 | $54.3M |
| 50 | First Community Foundation Partnership of Pennsylvania Williamsport | $40.1M | $19.8M | $167.6M |