| 1 | Dogwood Health Trust Asheville | $797.1M | $0 | $2.0B |
| 2 | Foundation for the Carolinas Charlotte | $761.6M | $761.4M | $3.9B |
| 3 | Burroughs Wellcome Fund Rtp | $542.0M | $0 | $848.0M |
| 4 | North Carolina Community Foundation INC Raleigh | $414.6M | $143.7M | $569.1M |
| 5 | Bissell Ballantyne Legacy Foundation Charlotte | $351.8M | $0 | $183.0M |
| 6 | The Golden L E a F Long-term Economic Advancement Foundation in Rocky Mount | $303.7M | $171.5M | $1.5B |
| 7 | Giveclear Foundation Charlotte | $233.2M | $214.9M | $215.4M |
| 8 | Bank of America Charitable Foundation INC Charlotte | $218.8M | $0 | $10.1M |
| 9 | Winston-salem Foundation Winston Salem | $185.6M | $46.6M | $630.1M |
| 10 | New Hanover Community Endowment INC Wilmington | $159.4M | $111.7M | $1.5B |
| 11 | C D Spangler Foundation INC Charlotte | $152.0M | $0 | $637.6M |
| 12 | Triangle Community Foundation Durham | $138.6M | $45.4M | $311.2M |
| 13 | William R Kenan Jr Charitable Trust Chapel Hill | $134.2M | $0 | $655.6M |
| 14 | Community Foundation of Greater Greensboro INC Greensboro | $132.4M | $19.2M | $289.6M |
| 15 | The United Methodist Retirement Homes INC Durham | $132.4M | $113.2M | $490.8M |
| 16 | John M Belk Endowment Charlotte | $115.3M | $0 | $379.0M |
| 17 | The Eddie and Jo Allison Smith Family Foundation INC Greenville | $115.1M | $0 | $302.1M |
| 18 | Blue Cross and Blue Shield of North Carolina Foundation Durham | $78.4M | $0 | $223.3M |
| 19 | Foundation for a Healthy High Point High Point | $76.0M | $0 | $57.0M |
| 20 | The Community Foundation of Western North Carolina INC Asheville | $75.0M | $25.9M | $434.9M |
| 21 | Charles a Cannon Charitable Trust N0 One Concord | $68.6M | $0 | $138.4M |
| 22 | The Asha and Sajjan Agarwal Foundation Raleigh | $66.8M | $0 | $134.4M |
| 23 | The Ezrah Charitable Trust Charlotte | $63.9M | $0 | $498.3M |
| 24 | The David Belk Cannon Foundation Gastonia | $60.2M | $0 | $132.5M |
| 25 | Wnc Bridge Foundation Asheville | $52.4M | $11.8M | $128.6M |
| 26 | A J Fletcher Foundation Raleigh | $48.4M | $12.1M | $279.2M |
| 27 | Luddy Charitable Foundation Raleigh | $46.6M | $0 | $61.1M |
| 28 | Gaston Community Foundation Gastonia | $46.4M | $12.1M | $145.4M |
| 29 | Robb and Veda Kaufman Holiness Advancement Foundation Lexington | $39.6M | $0 | $107.6M |
| 30 | Z Smith Reynolds Foundation INC Winston Salem | $39.4M | $0 | $23.6M |
| 31 | The Gambrell Foundation Charlotte | $37.1M | $0 | $172.6M |
| 32 | Kulynych Family Foundation II INC Charlotte | $35.4M | $0 | $49.6M |
| 33 | Community Foundation of Henderson County INC Hendersonville | $34.3M | $20.0M | $147.4M |
| 34 | Strickland Family Foundation Winston Salem | $33.0M | $0 | $50.8M |
| 35 | Joan H Gillings Foundation Writsvlle Bch | $30.1M | $0 | $43.7M |
| 36 | Bolick Foundation Conover | $29.6M | $0 | $55.1M |
| 37 | R B Terry Charitable Foundation INC High Point | $29.5M | $0 | $202.5M |
| 38 | Blackwelder Family Foundation Greenville | $26.5M | $0 | $31.3M |
| 39 | Louis Dejoy and Aldona Z Wos Family Foundation INC Greensboro | $25.7M | $0 | $44.5M |
| 40 | North Carolina Olympic Legacy Foun Charlotte | $24.1M | $0 | $11.2M |
| 41 | Reynolds American Foundation Winston Salem | $22.5M | $0 | $56.0M |
| 42 | Troon Foundation Elon | $22.4M | $0 | $49.1M |
| 43 | Goodnight Educational Foundation Cary | $21.9M | $0 | $145.0M |
| 44 | United Way of Greater Charlotte Charlotte | $21.2M | $20.6M | $32.2M |
| 45 | State Employees Credit Union Foundation Raleigh | $20.9M | $0 | $68.8M |
| 46 | Childtrust Foundation Raleigh | $20.5M | $0 | $21.0M |
| 47 | Ally Charitable Foundation Charlotte | $19.1M | $0 | $89.6M |
| 48 | Anonymous Trust Raleigh | $19.1M | $0 | $122.3M |
| 49 | The@w Duke Kimbrell Family Foundation Gastonia | $18.6M | $0 | $97.3M |
| 50 | Berry Charitable Foundation Greensboro | $18.4M | $0 | $74.6M |