| 1 | Greater Horizons Kansas City | $2.0B | $754.1M | $2.8B |
| 2 | Greater Kansas City Community Foundation Kansas City | $1.5B | $781.8M | $3.4B |
| 3 | Patterson Family Foundation Kansas City | $1.3B | $0 | $1.5B |
| 4 | Stifel Charitable INC Saint Louis | $1.1B | $340.5M | $508.8M |
| 5 | Patterson Family Foundation Kansas City | $341.9M | $0 | $1.5B |
| 6 | St. Louis Community Foundation Incorporated Saint Louis | $226.1M | $146.3M | $494.4M |
| 7 | Crawford Taylor Foundation Saint Louis | $216.3M | $0 | $758.8M |
| 8 | Community Foundation of the Ozarks INC Springfield | $153.5M | $57.7M | $479.9M |
| 9 | Leonard & Beryl Buck Foundation Saint Louis | $141.7M | $57.4M | $1.1B |
| 10 | Edward Jones Foundation Saint Louis | $134.5M | $0 | $138.9M |
| 11 | Hall Family Foundation Kansas City | $132.6M | $0 | $1.1B |
| 12 | United Way of Greater St. Louis INC Saint Louis | $115.1M | $81.4M | $123.3M |
| 13 | Jefferson Foundation Festus | $101.9M | $0 | $196.6M |
| 14 | Midway USA Foundation INC Columbia | $89.7M | $36.2M | $359.7M |
| 15 | Marion and Henry Bloch Family Foundation Kansas City | $85.6M | $0 | $650.5M |
| 16 | Ten Talents Foundation Saint Louis | $81.9M | $0 | $147.0M |
| 17 | James S McDonnell Foundation Saint Louis | $67.4M | $0 | $457.5M |
| 18 | Tw Ld McEachearn Saint Louis | $66.1M | $0 | $136.0M |
| 19 | Jewish Federation of St. Louis Saint Louis | $65.9M | $20.0M | $152.7M |
| 20 | Herzog Foundation Resource Management Smithville | $63.1M | $60.0M | $50.1M |
| 21 | Kc Peoples Fund Kansas City | $50.8M | $0 | $24.0M |
| 22 | William R Orthwein Jr and Laura Rand Orthwein Foundation INC Saint Louis | $49.7M | $0 | $76.7M |
| 23 | Roman Catholic Foundation of Eastern Missouri Saint Louis | $46.5M | $10.5M | $79.6M |
| 24 | Hagan Trust Columbia | $43.8M | $0 | $268.6M |
| 25 | Carlos and Marguerite Mason Foundation Saint Louis | $43.4M | $0 | $102.8M |
| 26 | Worldwide Inventory Network INC Saint Louis | $43.2M | $43.2M | $163.1M |
| 27 | Robert K Johnson Foundation Saint Louis | $37.5M | $0 | $89.2M |
| 28 | The Global Orphan Project INC Kansas City | $34.6M | $32.3M | $19.2M |
| 29 | St. Louis Community Foundation Saint Louis | $33.3M | $15.4M | $104.0M |
| 30 | Dennis M Jones Family Foundation Saint Louis | $33.0M | $0 | $41.2M |
| 31 | Paula and Rodger Riney Foundation Saint Louis | $31.6M | $0 | $55.6M |
| 32 | Veterans United Foundation Columbia | $28.5M | $10.3M | $38.7M |
| 33 | The W W Smith Charitable Trust Saint Louis | $28.3M | $0 | $243.2M |
| 34 | William a Badger Foundation Saint Louis | $26.0M | $0 | $53.5M |
| 35 | Maccarthy Foundation Saint Louis | $25.2M | $0 | $105.3M |
| 36 | Robert F Schumann Foundation Saint Louis | $24.5M | $0 | $46.7M |
| 37 | Lutheran Family and Childrens Services Foundation INC St. Louis | $24.1M | $4.4M | $21.8M |
| 38 | Firefly Scientists Foundation Saint Louis | $22.2M | $0 | $74.9M |
| 39 | The Saigh Foundation Clayton | $21.4M | $0 | $65.4M |
| 40 | World Wide Technology Foundation Saint Louis | $20.6M | $0 | $16.1M |
| 41 | Greater Horizons Trust Kansas City | $20.4M | $10.1M | $59.4M |
| 42 | McKean Fam Foundation Tr Saint Louis | $19.3M | $0 | $20.1M |
| 43 | Interco Charitable Trust Clayton | $19.2M | $0 | $34.0M |
| 44 | Community Impact Network Saint Louis | $17.9M | $0 | $25.3M |
| 45 | Alexander McCausland Charitable Tr Saint Louis | $17.3M | $0 | $18.0M |
| 46 | Kranzberg Family Charitable Foundation Dtd 6-3-2000 Saint Louis | $16.5M | $0 | $20.4M |
| 47 | Eric P and Evelyn Newman Charitable Foundation Saint Louis | $15.7M | $0 | $59.3M |
| 48 | Christmas Valley Foundation Wildwood | $15.4M | $0 | $12.2M |
| 49 | Truman Heartland Community Foundation Independence | $15.1M | $15.0M | $104.8M |
| 50 | Community Foundation of Northwest Missouri Saint Joseph | $13.0M | $13.0M | $41.3M |