| 1 | Blue Cross & Blue Shield of Mississippi Foundation Flowood | $38.0M | $0 | $162.6M |
| 2 | Community Foundation for Mississippi Jackson | $31.9M | $15.1M | $90.3M |
| 3 | Create Foundation INC Tupelo | $26.7M | $26.2M | $181.6M |
| 4 | Mississippi Power Foundation INC Gulfport | $24.2M | $0 | $46.3M |
| 5 | Luckyday Foundation Jackson | $20.8M | $0 | $146.6M |
| 6 | Paul & Sherry Broadhead Foundation Meridian | $14.6M | $0 | $25.7M |
| 7 | Community Foundation of Northwest Mississippi INC Hernando | $12.4M | $10.1M | $48.6M |
| 8 | The Greater Pinebelt Community Foundation Hattiesburg | $11.4M | $11.2M | $36.4M |
| 9 | Brevard Family Foundation Tupelo | $10.8M | $0 | $21.3M |
| 10 | James W Hood Family Foundation Jackson | $9.7M | $0 | $20.5M |
| 11 | Gulf Coast Community Foundation INC Gulfport | $7.5M | $2.8M | $37.1M |
| 12 | Maddox Foundation Hernando | $7.3M | $0 | $5.1M |
| 13 | Leo Seal Family Foundation Bay St. Louis | $7.3M | $0 | $11.6M |
| 14 | Cadence Bank Foundation Tupelo | $7.2M | $0 | $43.2M |
| 15 | Joseph C Bancroft Charitable & Educational Fund McComb | $6.9M | $6.8M | $204.0M |
| 16 | Charles & Cynthia Bell Foundation Vicksburg | $6.0M | $0 | $7.6M |
| 17 | Foundation for Mississippi History Jackson | $5.9M | $1.4M | $8.9M |
| 18 | Oakwood Foundation Charitable Tr Tupelo | $5.4M | $0 | $7.7M |
| 19 | Larry Wiggers Overby Foundation Brandon | $4.6M | $0 | $12.8M |
| 20 | Ms Breast Foundation Rolling Fork | $4.2M | $1.0M | $144K |
| 21 | Fountain Family Foundation Jackson | $4.2M | $0 | $6.8M |
| 22 | Parker Lifeshare Foundation Madison | $4.0M | $0 | $13.8M |
| 23 | United Way of Union County INC Tupelo | $3.9M | $2.8M | $4.2M |
| 24 | Chester K Burnham Charitable Tr Hazlehurst | $3.8M | $2.5M | $888K |
| 25 | Blue Scooter Foundation Vicksburg | $3.7M | $0 | $2.1M |
| 26 | Institute for the Advancement of Minority Health Ridgeland | $3.5M | $3.5M | $1.5M |
| 27 | Purvis Grange Foundation INC Vicksburg | $3.3M | $0 | $21.9M |
| 28 | Community Foundation of East Mississippi INC Meridian | $3.0M | $1.4M | $10.7M |
| 29 | Dr and Mrs R Faser Triplett Foundation Madison | $2.9M | $0 | $6.3M |
| 30 | Northeast Mississippi Community College Development Foundation INC Booneville | $2.8M | $2.8M | $10.8M |
| 31 | Powell Foundation INC Tupelo | $2.6M | $0 | $9.3M |
| 32 | The Noblitt Foundation Jackson | $2.6M | $0 | $5.3M |
| 33 | Community Foundation of Washington County INC Greenville | $2.5M | $2.5M | $4.5M |
| 34 | United Way of Northeast Mississippi INC Tupelo | $2.4M | $2.2M | $3.4M |
| 35 | Warren a Hood Jr Family Foundation Hattiesburg | $2.4M | $0 | $17.3M |
| 36 | Henry Mize Charitable Foundation INC Tupelo | $2.4M | $469K | $6.6M |
| 37 | Cannon Charitable Foundation INC Flowood | $2.3M | $0 | $1.0M |
| 38 | Wheaton Foundation Jackson | $2.3M | $0 | $154K |
| 39 | Lower Pearl River Valley Foundation Picayune | $2.2M | $0 | $25.4M |
| 40 | Hellfighters International Laurel | $2.0M | $909K | $3.7M |
| 41 | United Way of South Mississippi INC Gulfport | $2.0M | $1.9M | $1.1M |
| 42 | Patterson Family Foundation INC Tupelo | $1.9M | $0 | $3.4M |
| 43 | Bill McCarty III Foundation Jackson | $1.8M | $0 | $1.5M |
| 44 | East Central Community College Foundation INC Decatur | $1.8M | $1.8M | $10.5M |
| 45 | Real Christian Foundation INC Richland | $1.8M | $753K | $5.2M |
| 46 | Burdette Family Foundation Pass Chris | $1.7M | $0 | $4.2M |
| 47 | Artz-white Foundation Columbus | $1.6M | $262K | $4.4M |
| 48 | H F McCarty Jr Family Foundation Ridgeland | $1.6M | $0 | $8.0M |
| 49 | United Way of Southeast Mississippi INC Hattiesburg | $1.5M | $1.4M | $2.5M |
| 50 | Bbb Foundsation Columbus | $1.5M | $0 | $2.7M |