| 1 | Puffin Bay Foundation Biddeford | $784.2M | $0 | $679.0M |
| 2 | Maine Community Foundation INC Ellsworth | $660.3M | $138.8M | $807.6M |
| 3 | Harold Alfond Foundation Portland | $191.7M | $0 | $1.0B |
| 4 | Kahle-austin Family Foundation Biddeford | $181.1M | $0 | $118.7M |
| 5 | Kahle-austin Foundation Biddeford | $129.4M | $0 | $161.8M |
| 6 | Blue Horizons Foundation Gorham | $101.0M | $0 | $239.7M |
| 7 | John T Gorman Foundation Portland | $70.0M | $0 | $223.5M |
| 8 | Evelyn S and K E Barrett Foundation York | $49.4M | $0 | $33.9M |
| 9 | Worthington Scholarship Foundation Rockland | $44.2M | $0 | $45.2M |
| 10 | University of Southern Maine Foundation Portland | $27.8M | $14.3M | $58.6M |
| 11 | Td Charitable Foundation Portland | $27.3M | $0 | $9.0M |
| 12 | Lesher Family Foundation Rockport | $24.0M | $4.9M | $40.4M |
| 13 | Shaw Brothers Family Foundation INC Gorham | $15.2M | $0 | $29.0M |
| 14 | J Blair and Tena Frank Foundation Portland | $14.8M | $0 | $30.4M |
| 15 | The Masonic Charitable Foundation of the Grand Lodge of Maine Holden | $14.3M | $4.8M | $36.8M |
| 16 | United Way INC Portland | $11.5M | $9.5M | $20.2M |
| 17 | Wolfes Neck Farm Foundation INC Freeport | $10.4M | $9.7M | $18.6M |
| 18 | The Pasculano Foundation Cape Eliz | $9.6M | $0 | $21.3M |
| 19 | Davis Family Foundation Yarmouth | $9.2M | $3.7M | $100.5M |
| 20 | Marr-anderson Family Foundation Falmouth | $8.6M | $0 | $19.1M |
| 21 | Rocking Moon Foundation INC Yarmouth | $7.8M | $0 | $15.7M |
| 22 | Pond Family Foundation Scarborough | $7.7M | $0 | $6.2M |
| 23 | Sam L Cohen Foundation Portland | $7.2M | $0 | $28.2M |
| 24 | Cascade Foundation Rockport | $6.9M | $0 | $12.9M |
| 25 | Pine Tree Housing Agency Portland | $6.7M | $1.1M | $7.6M |
| 26 | Jewish Community Alliance of Southern Maine Portland | $6.4M | $5.3M | $13.3M |
| 27 | Maine Community Supporting Foundation Ellsworth | $5.9M | $2.9M | $0 |
| 28 | Roxanne Quimby Foundation INC Portland | $5.3M | $0 | $28.8M |
| 29 | Francis T & Louise T Nichols Foundation Bangor | $5.2M | $0 | $20.8M |
| 30 | Dbp Foundation Old Orchd Bch | $5.1M | $0 | $1.6M |
| 31 | Quimby Family Foundation Portland | $5.1M | $0 | $21.5M |
| 32 | Barbara Cassidy Foundation Biddeford | $5.0M | $0 | $4.2M |
| 33 | Margaret Chase Smith Foundation Portland | $4.8M | $0 | $16.6M |
| 34 | Maine Workers Compensation Policyholder Tr Augusta | $4.2M | $2.5M | $19.5M |
| 35 | Machias Savings Bank Community Development Foundation Machias | $4.2M | $0 | $3.9M |
| 36 | Abbagadassett Foundation INC Bowdoinham | $3.6M | $0 | $12.6M |
| 37 | Moser Family Foundation INC Portland | $3.3M | $0 | $6.9M |
| 38 | Evergreen Foundation Georgetown | $2.9M | $0 | $10.4M |
| 39 | William J Chase Charitable Trust Eliot | $2.7M | $0 | $1.4M |
| 40 | Flynn Family Foundation Kennebunk | $2.7M | $0 | $2.6M |
| 41 | Bangor Savings Bank Foundation Bangor | $2.6M | $0 | $7.0M |
| 42 | Heart of Maine United Way Bangor | $2.5M | $2.4M | $5.5M |
| 43 | The Bob Crewe Foundation Falmouth | $2.5M | $0 | $15.7M |
| 44 | Burns Family Foundation INC Damariscotta | $2.5M | $0 | $6.7M |
| 45 | Information Technology Exchange Searsport | $2.4M | $2.4M | $1.8M |
| 46 | Margaret E Burnham Charitable Tr Portland | $2.4M | $0 | $7.4M |
| 47 | Foundation for Portland Public Schools Portland | $2.2M | $2.2M | $2.2M |
| 48 | The Lawrence Family Foundation Holden | $2.2M | $0 | $16.0M |
| 49 | Narragansett Number One Foundation Bar Mills | $2.2M | $0 | $5.3M |
| 50 | United Way of Kennebec Valley Augusta | $2.1M | $2.0M | $3.6M |